Skeletal Dentoalveolar and Soft Tissue Effects of β Thalassemia Major

Yıl 2017, Cilt: 9 Sayı: 2, 39 - 49, 01.12.2017

Atılım Akkurta Mehmet Dogru Arzum Guler Dogru Kamile Keskin

Öz

Objective: Thalassemia (TH) is a genetic disorder of hemoglobin synthesis caused by the absence or reduced synthesis of globin chains which causes different craniofacial effects. The purpose of this study is to evaluate the skeletal, dental and soft tissue cephalometric features of TH patients.
Materials and Methods: Present study consisted of lateral cephalometric images obtained from CBCT scans of 25 TH (mean age: 13,7±3,8 years) and 50 normal (mean age: 13,9±1,81 years) individuals. An Independent sample t was used to compare the cephalometric measurements.
Results: TH patients revealed a high angle Class II pattern (SnGoMe, Sum p<0,01, ANS-PNS/GoMe, ANB, p<0,001) caused by retruded mandible (SNB, SNPog, p<0,001) with retrusive upper (U1-Na°, p<0,01, U1-Na mm p<0,001) and protrusive lower incisors (L1Nb °, p<0,001, IMPA, p<0,05, L1Nb mm, p<0,01). Except the S-N length (p>0.05), all craniofacial parameters (S-Ar p<0,05, S-Go p<0,01, Ar-Go, N-Me p<0,05, Go-Me, S-Go/N-Me p<0,001) of TH patients’ found significantly smaller than that obtained from normal individuals. On the contrary ANS-PNS parameter (p<0,01) was found significantly bigger in TH patients’. In addition TH patients have protrusive upper (p<0,05) and lower lips (p<0,01) accompanied with an increased nasolabial angle (p<0,01) when compared with normal individuals.
Conclusion: A high angle Class II pattern caused by the retrusion and clockwise rotation of mandible accompanied with retrusive upper, protrusive lower incisors and protrusive upper and lower lips may be considered the most common craniofacial features of TH patients.

Anahtar Kelimeler

protrusive

Kaynakça

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