Yıl 2017, Cilt 9 , Sayı 2, Sayfalar 51 - 60 2017-12-01

108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey

Diclehan Oral [1] , Selda Şimşek [2] , Hilmi İsi [3] , İlyas Yüce [4]


The relationship between abnormal chromosomal constitution and sex anomalies has been established since the development of cytogenetic and molecular methods. In order to investigate the relationship between sex dysplasia and sex-determining region Y (SRY) gene, 108 patients with sexual abnormality were analyzed by cytogenetic and molecular genetic methods. SRY gene was amplified by polymerase chain reaction (PCR) and its mutation was detected by direct sequencing. The results showed that among 108 patients, 49 were positive for SRY and the remaining negative for SRY. In the patients positive for SRY genes, with 45, X/46, XY 46, XXY,46,XX karyotype, In the patients negative for SRY, with 46,XY,46, XX karyotype It was concluded that SRY gene is strongly involved in male sex determination, while a sequence of other genes may be taken into account in sexual development. . It is also essential for defining genotypic and phenotypic correlation and understanding the basic mechanism involved in sex determination.

Chromosome; Sry gene; sex abnormality
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Birincil Dil en
Konular Genel ve Dahili Tıp
Yayımlanma Tarihi 01-12-2016
Bölüm Araştırma
Yazarlar

Yazar: Diclehan Oral (Sorumlu Yazar)

Yazar: Selda Şimşek

Yazar: Hilmi İsi

Yazar: İlyas Yüce

Tarihler

Yayımlanma Tarihi : 1 Aralık 2017

Bibtex @araştırma makalesi { iamr511392, journal = {International Archives of Medical Research}, issn = {2146-6033}, address = {Dicle Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD, 21280, Diyarbakır-Türkiye}, publisher = {Veysi AKPOLAT}, year = {2017}, volume = {9}, pages = {51 - 60}, doi = {}, title = {108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey}, key = {cite}, author = {Oral, Diclehan and Şimşek, Selda and İsi, Hilmi and Yüce, İlyas} }
APA Oral, D , Şimşek, S , İsi, H , Yüce, İ . (2017). 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey. International Archives of Medical Research , 9 (2) , 51-60 . Retrieved from https://dergipark.org.tr/tr/pub/iamr/issue/42453/511392
MLA Oral, D , Şimşek, S , İsi, H , Yüce, İ . "108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey". International Archives of Medical Research 9 (2017 ): 51-60 <https://dergipark.org.tr/tr/pub/iamr/issue/42453/511392>
Chicago Oral, D , Şimşek, S , İsi, H , Yüce, İ . "108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey". International Archives of Medical Research 9 (2017 ): 51-60
RIS TY - JOUR T1 - 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey AU - Diclehan Oral , Selda Şimşek , Hilmi İsi , İlyas Yüce Y1 - 2017 PY - 2017 N1 - DO - T2 - International Archives of Medical Research JF - Journal JO - JOR SP - 51 EP - 60 VL - 9 IS - 2 SN - 2146-6033- M3 - UR - Y2 - 2020 ER -
EndNote %0 International Archives of Medical Research 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey %A Diclehan Oral , Selda Şimşek , Hilmi İsi , İlyas Yüce %T 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey %D 2017 %J International Archives of Medical Research %P 2146-6033- %V 9 %N 2 %R %U
ISNAD Oral, Diclehan , Şimşek, Selda , İsi, Hilmi , Yüce, İlyas . "108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey". International Archives of Medical Research 9 / 2 (Aralık 2017): 51-60 .
AMA Oral D , Şimşek S , İsi H , Yüce İ . 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey. IAMR. 2017; 9(2): 51-60.
Vancouver Oral D , Şimşek S , İsi H , Yüce İ . 108 patients with sex abnormality; cytogenetic and molecular analysis in Diyarbakır, Turkey. International Archives of Medical Research. 2017; 9(2): 60-51.