Examination of the obesogenic effects of Bisphenol-A

Abstract

The prevalence of obesity among people has increased dramatically in recent years in all the world. It is not enough to explain this increasing trend only with people's lifestyle, eating habits and cultural differences. Some chemicals, which are taken into the human body, especially through the food chain and are considered to be endocrine disruptors, affect the frequency of obesity. Endocrine disrupting chemicals (EDCs) are compounds that cause hormone disruption and elimination of the functions of these hormones. Bisphenol-A (BPA) is one of the most intensive chemicals in human life and is generally called 2,2-bis (4-hydroxyphenyl) propane. 70% of the BPA in the world is used in polycarbonate plastics and 30% in epoxy resins. Due to the widespread usage of it, BPA reaches solid and liquid wastes in terrestrial and aquatic ecosystems in large quantities. Considering the high production capacity of BPA and its different application areas, it is claimed that significant amount of BPA enters the environment. Studies show that the rate of being exposed to BPA has an increasing tendency. In the literature, the rate of availability in drinking water and the data on the reproductive system were only included in the researches related to BPA. Therefore, this study aimed to observe the obesogenic role of BPA in the development of obesity, which is the current health problem of the world. BPA is an endocrine disrupting chemical known to have in vitro effects on glucose metabolism and adipose tissue. In a limited number of clinical and epidemiological studies, BPA has been shown to be associated with diabetes and obesity. For this purpose, the current literature related to this issue has been reviewed and the effects of BPA on obesity have been compiled both in the world and in our country.

Keywords

• Bisphenol A,Endocrine system,Obesity,Polycarbonate plastic

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