İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2149-4401 2547-9466 Demiroğlu Bilim Üniversitesi 10.5606/fng.btd.2015.008 Deneysel diyabet modelleri Erbaş Oytun 08 18 2015 1 1 08 18 2015 Copyright © 2015, İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2015 İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi

Diabetes mellitus (DM) is a chronic metabolic syndrome with hyperglycemia. It consists because of insulin deficiency/resistant, and ends up with disregulation of protein, carbohydrate and lipid metabolism. Diabetes mellitus is one of the most common chronic disease. Genetic and environmental factors act together on development of DM. The modelling of DM and investigating its complications is an important subject. It could be possible to try new agents to inhibit development of macro and microvascular complications of DM, by experimental modelling. Streptozocin and alloxan are most frequently used agents to create DM model. In recent years, use of mutant spontaneous diabetic rats inspite of DM modelling is current. Thus, direct tissue damage during diabetic induction by streptozocin and alloxan is avoided and effects related hyperglycemia come in sight simply

Diyabetes mellitus, insülin eksikliği veya insülinin etkisiz kalması sonucu oluşan; birlikte karbonhidrat, protein ve yağ metabolizması düzensizliğinin eşlik ettiği hiperglisemi ile seyreden kronik metabolik bir sendromdur. Diyabetes mellitus toplumda en sık g.rülen kronik hastalıklardan biridir.Diyabet hastalığının gelişiminde genetik ve çevresel faktörler birlikte rol oynar. Deney hayvanlarında diyabet hastalığının modellenmesi ve komplikasyon mekanizmalarının anlaşılması önemli bir konudur. Diyabete bağlı mikro ve makrovasküler komplikasyonların gelişiminin önlenmesi için yeni ajanların denenmesi modelleme ile mümkün olmaktadır. Streptozosin ve alloksan deneysel diyabet oluşturmak için en sık kullanılan ajanlardır.Son yıllarda genetik mutasyonlu spontan diyabetik sıçanların kullanılması daha güncel bir konudur. Böylece diyabetik indüksiyon için kullanılan streptozosin ve alloksana bağlı oluşabilecek direkt doku hasarı önlenmekte ve sadece hiperglisemiye bağlı etkilerin daha yalın olarak ortaya çıkması sağlanmaktadır.Anahtar sözcükler: Alloksan; diyabet modelleme; Goto-Kakizaki; streptozosin.

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