Propranolol ve kanser

Yıl 2018, Cilt: 3 Sayı: 1-2, 31 - 37, 04.04.2019

Zehra Pınar Cengiz Oytun Erbaş

Öz

Propranolol hipertansiyondan benign infantil hemanjiyom tedavisine kadar klinik etkiler gösteren ve günümüzde daha agresif vasküler sarkomlar ve diğer kanserler için kullanılan bir beta adrenerjik reseptör inhibitörüdür. Spesifik olmayan beta adrenerjik bloklayıcı bir ilaç olan propranolol, katekolaminlerin reseptörlere bağlanmasını ve kanser hücrelerinin çoğalmasını önler. Bu nedenle, onkolojide önemli bir geri dönüşüm adayıdır. Propranololün anti-tümör aktivitesi, farklı kanser türlerinde tedavi ve profilaksi amacıyla kullanılabilir. Bu derlemede, propranol'ün hemanjiyom, meme, pankreas ve prostat kanserleri üzerindeki profilaktik etkileri tartışıldı.

Anahtar Kelimeler

Kanser, beta bloker, profilaksi, propranolol

Kaynakça

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