A Novel Embedded System on Cold Box Design for The Cold Chain

Abstract

The “cold chain” enables to remain safely the vaccines and medicines at the recommended temperature ranges during their transportation and storage period from the production site to the end user. The cold chain system is very important because of that vaccines and medicines lose their effectiveness when they exposed to a temperature above or below the limited ranges. There is no benefit of the vaccination also, if the vaccines and medicines used were ineffective; on the contrary, the vaccine can injure the applied organism. In this study, a kit based on “Arduino” was designed to ensure the continuity of the cold chain effectiveness. With this study intended was a new system designed, which enables a real time temperature and humidity control of the cold chain system in the transport ambient conditions so that it will alert when the cold chain system should have a malfunction. On the other hand, the experimental results obtained were compared which were sensitively measured with a laser thermometer capable for remote measuring. There was no difference between the results obtained and the values measured by the laser thermometer. Additionally, performance analyses of the system at the different temperatures have revealed that it is capable to stabilize the temperature value successfully.

Keywords

• Control,Cold chain,Cold Box,Embedded system

References

1. D. M. Matthias, J. Robertson, M. M. Garrison, S. Newland, and C. Nelson, "Freezing temperatures in the vaccine cold chain: a systematic literature review," Vaccine, vol. 25, pp. 3980-3986, 2007.
2. T. E. Odası, "Cold Chain (Soguk Zincir)," Trabzon Ecazılar Odası, Trabzon2017.
3. S. Techathawat, P. Varinsathien, A. Rasdjarmrearnsook, and P. Tharmaphornpilas, "Exposure to heat and freezing in the vaccine cold chain in Thailand," Vaccine, vol. 25, pp. 1328-1333, 2007/01/26/ 2007.
4. C. Nelson, P. Froes, A. M. V. Dyck, J. Chavarría, E. Boda, A. Coca, et al., "Monitoring temperatures in the vaccine cold chain in Bolivia," Vaccine, vol. 25, pp. 433-437, 2007/01/05/ 2007.
5. I. University. (2017, 06.05.2017). Istanbul Faculty of Medicine Cold Chain Drug Control Instruction. Available: http://istanbultip.istanbul.edu.tr/wp-content/uploads/2014/02/ So%C4%9Fuk-Zincir-%C4%B0la%C3%A7lar%C4%B1n-Kontrol% C3%BC-Talimat%C4%B1.pdf
6. F. D. Acu, A. A. Adedeji, J. S. Esan, and O. G. Odusanya, "Live viral vaccine potency: an index for assessing the cold chain system," Public Health, vol. 110, pp. 325-330, 1996/11/01/ 1996.
7. E. Weir and K. Hatch, "Preventing cold chain failure: vaccine storage and handling," Canadian Medical Association Journal, vol. 171, pp. 1050-1050, 2004.
8. (2017). Cold Chain - Logistics Operational Guide (LOG) - Digital Logistics Capacity Assessments. Available: http://dlca.logcluster.org/display/LOG/Cold+Chain

9. A. İ. S. Müdürlüğü. (2017, 06.05.2017). İlaç Güvenliği Rehberi. Available: http://www.asm.gov.tr/UploadGenelDosyalar/Dosyalar/143/B%C4%B0LG%C4%B0/13_04_2017_11_31_27.pdf
10. S. Devrani, S. Pandey, S. Chaturvedi, K. Sankar, S. Patil, and K. Sridhar, "Design and Analysis of an Efficient Vaccine Cold Chain Box," in ASME 2016 International Mechanical Engineering Congress and Exposition, 2016, pp. V003T04A018-V003T04A018.
11. D. G. F. v. S. C, "Verimlilik Gözlemlerinde Eczacılık Hizmetleri Ve Medikal Depo Boyutu," Ankara2017.
12. U. Fidan, "Mikrodenetleyici Kontrollü Taşınabilir Termoelektrik Tıp Kiti Cihaz Tasarımı Ve Uygulaması, Yüksek Lisans Tezi (yayımlanmış), Gazi Üniversitesi Fen Bilimleri Enstitüsü," Elektronik Bilgisayar Eğitimi, Ankara, 2000.
13. H. Çakır, "Güneş Piliyle Elde Edilen Elektrik Enerjisinin Termoelektrik Soğutmada Kullanılması," Yüksek Lisans Tezi (yayımlanmış), Zonguldak Karaelmas Üniversitesi Fen Bilimleri Enstitüsü, Makine Eğitimi, Zonguldak, vol. 1, 2006.
14. Alpin. (2017). Portatif, küçük bir buzdolabı yapımı - Kendin Yap - Proje Yapımı Sitesi. Available: http://www.kendinyapsitesi.com/proje.asp?id=1384
15. H. Dalkılıç and M. H. Özcanhan, "Gömülü Sistem Tabanlı Model Mobil Aracın Akıllı Telefonla Uzaktan Kontrolu," XVIII. Akademik Bilişim Konferansı--AB, vol. 30, 2016.
16. C. Taşdemir, "Arduino Analog-Dijital-Sensörler-Haberleşme-Projeler," Türkiye Dikeyeksen Yayıncılık, vol. 1, p. 67, 2012.
17. K. Kayaalp and S. Özkorucuklu, "ARDUİNO TEKNOLOJİSİ KULLANILARAK TARLA İÇİN RADYASYON KAPI KONTROLÜ TASARIMI," SDU International Journal of Technological Science, vol. 7, 2015.
18. (2017, 07.05.2017). What is Arduino Mega 2560? . Available: http://arduinoturkiye.com/arduino-mega-2560-nedir/
19. (2017, 07.05.2017). DHT22 Temperature and Humidity Sensors. Available: DHT22 Isı ve Nem Sensörü
20. Arduino.cc. (2017, 10.05.2017). Arduino - Software IDE. Available: https://www.arduino.cc/en/main/software
21. C. T. Chen and C. Hwang, "Optimal on-off control for fed-batch fermentation processes," Industrial & engineering chemistry research, vol. 29, pp. 1869-1875, 1990.
22. (2017, 12.05.2017). What is On/Off Control. Available: http://www.coulton.com/What_is_On_Off_Control.html