Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri

Abstract

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Abstract

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

Keywords

• Chalcone
• Anticholinesterase activity
• Tyrosinase inhibitory activity
• Urease inhibitory activity

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