Developing new polymeric nanoparticles for controlled release of quercetin as an alternative material protecting from COVID-19

Abstract

Research of drugs for COVID-19, the most striking studies include the ACE-2 receptors used by COVID-19 by binding to the lung cells for entry. In the researchers conducted, it was determined by the results of the docking studies performed on the agents that block the receptor by binding to the receptor, such as COVID-19, several molecules have the interest to bind to this receptor. One of these numbered molecules is herbal flavonoid called "Quercetin". In this study, quercetin imprinted polymeric materials were designed, synthesized and characterized. For synthesis, emulsion polymerization technique was used for obtaining quercetin imprinted polymeric materials. SEM and Zeta-Size analysis were used as preliminary characterization. After a week release experiment, quercetin imprinted polymeric nanoparticles were released by 14%. In the light of these results, it is predicted that quercetin printed polymeric material can be used for protection from COVID-19 and treatment of COVID-19 on the inhaler route.

Keywords

• COVID-19
• Quercetin
• Nanoparticles
• Flavanoids

References

1. Khaerunnısa, S.; Kurniawan, H.; Awaluddin, R.; Suhartati, S.; Soetjipto, S.; Pharmacology & toxicology 2020, 20944, 1-14.
2. Sargiacomo, C.; Sotgia, F.; Lisanti, MP.; Aging (Albany NY) 2020, 12, 6511.
3. Glınsky, G.V.; Biomedicines, 2020, 8, 129.
4. Glınsky, G.V.; Biolocigal and Medicinal Chemistry, 2020.
5. Piletska, E.V.; Turner, N.W.; Turner, A.P; Piletsky, S.A.; Journal of Controlled Release 2005, 108, 132-139.
6. Omar, S.; Bouziane, I.; Bouslama, Z.; Djemel, A.; Biological and Medicinal Chemistry, 2020.
7. Alschuler, L.; Weil, A.; Horwitz, R.; Stamets, P.; Chiasson, A.M.; Crocker, R.; Maizes, V.; Explore (New York, NY) 2020.
8. Inanan, T.; International journal of biological macromolecules 2016, 92, 451-460.

9. Türkcan, C.; Somtürk, B.; Özdemir, N.; Özel, M.; Çatalkaya, R.; Aktaş Uygun, D.; Akgöl, S.; Journal of Biomaterials Science, Polymer Edition 2019, 30, 947-960.
10. 1O’Mahony, J.; Molinelli, A.; Nolan, K.; Smyth, M.R.; Mizaikoff, B.; Biosensors and Bioelectronics 2006, 21, 1383-1392.
11. Song, X.; Wang, J.; Zhu, J.; Materials Research 2009, 12, 299-304.
12. Xie, J.; Zhu, L.; Luo, H.; Zhou, L.; Li, C.; Xu, X.; Journal of Chromatography A 2001, 934, 1-11.
13. Rahimi, M.; Bahar, S.; Heydari, R.; Amininasab, S.M.; Microchemical Journal 2019, 148, 433-441.
14. Yao, Z.; Yang, X.; Liu, X.; Yang, Y.; Hu, Y.; Zhao, Z.; Microchimica Acta 2018, 185, 70.
15. Patel, G.; Thakur, N.S.; Kushwah, V.; Patil, M.D.; Nile, S.H.; Jain, S.; Banerjee, U.C.; Nanomedicine: Nanotechnology, Biology and Medicine 2020, 24, 102147.
16. Anandam, S.; Selvamuthukumar, S.; Journal of Materials Science 2014, 49, 8140-8153.
17. Lozano-Pérez, A.A.; Rivero, H.C.; Hernández, M.D.C.P.; Pagán, A.; Montalbán, M.G.; Víllora, G.; Cénis, J.L.; International Journal of Pharmaceutics 2017, 518, 11-19.
18. Hazra, M.; Saudi pharmaceutical journal 2015 23, 429-436.
19. Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Picci, N.; Puoci; F.; Journal of functional biomaterials, 2012, 3, 269-282.