Green synthesized seaweeds-based metal nanoparticles: therapeutic prospective for anticancer activity

Abstract

Nanoparticles containing metals such as silver, gold, copper, zinc, iron and magnesium are prepared via green synthesis by numerous prokaryotic and eukaryotic organisms used in medical and various industrial applications. Nanoparticles in medical applications play an important role in the diagnosis of diseases by bioimaging, and in the treatment of diseases by gene and drug delivery, tissue engineering and implant applications. In the last ten years, numerous studies reported on the biosynthesis of metal nanoparticles and their effect on cancer cell lines utilizing seaweed extracts. Seaweeds is preferred because it has more advantages over other bio-sources in production via green synthesis of nanoparticles. Our findings clearly show that metal nanoparticles prepared by green synthesis using different seaweed species extracts damage cancer cells at the concentration range of 0.40-344 ug/mL and cause their deaths in laboratory experiments carried out in vivo. In this work, we provide details on the use of seaweed in metal nanoparticle synthesis, characterization methods, its advantages, and the applications of synthesised nanoparticles in cancer treatments.

Keywords

• green synthesis
• metal nanoparticles
• seaweeds
• anticancer effect
• cytotoxic activity

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