Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects

Celal Bal

doi:10.32571/ijct.1668272

EN

Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects

Abstract

Mushrooms have constituted a wide research area as natural resources exhibiting medically important biological activities. This study aimed to investigate the biological activities of Leucoagaricus leucothites (Vittad.) Wasser mushroom comprehensively. Ethanol extract of the mushroom was obtained by Soxhlet extraction method. To determine the biological potential of the extract, total antioxidant status (TAS) and total oxidant status (TOS) analyses were performed by Rel Assay kits. In addition, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme activities were measured to evaluate the anticholinesterase activity of the mushroom. A549 lung cancer cell line was used to determine the antiproliferative effect. The obtained data showed that the TAS value of L. leucothites was 6.109±0.078 mmol/L and the TOS value was 15.364±0.149 µmol/L. Oxidative stress index (OSI) was calculated as 0.251±0.003. In terms of anticholinesterase activity, AChE inhibition value was found as 106.08±1.76 µg/mL, BChE inhibition value was found as 129.88±1.62 µg/mL. Antiproliferative effect increased in parallel with the increase in concentration, and this situation revealed that L. leucothites has a strong potential in terms of biological activities. These findings show that L. leucothites can be used in health supportive treatment approaches and can be a valuable source in pharmaceutical applications.

Keywords

Supporting Institution

non

Ethical Statement

There is no conflict of interest with any person, institution, company, etc.

Thanks

I would like to thank Dr. Ayşenur Gürgen and Dr. Mustafa Sevindik for their support in the experimental stages of the article.

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Celal Bal ^*
0000-0001-6856-3254
Türkiye

Early Pub Date

June 24, 2025

Publication Date

June 24, 2025

Submission Date

March 30, 2025

Acceptance Date

June 15, 2025

Published in Issue

Year 2025 Volume: 9 Number: 1

DOI

https://doi.org/10.32571/ijct.1668272

IZ

https://izlik.org/JA55RY37DR

Cite

RIS / Bibtex

APA

Bal, C. (2025). Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects. International Journal of Chemistry and Technology, 9(1), 147-152. https://doi.org/10.32571/ijct.1668272

AMA

1.Bal C. Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects. Int. J. Chem. Technol. 2025;9(1):147-152. doi:10.32571/ijct.1668272

Chicago

Bal, Celal. 2025. “Biological Activities of Leucoagaricus Leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects”. International Journal of Chemistry and Technology 9 (1): 147-52. https://doi.org/10.32571/ijct.1668272.

EndNote

Bal C (June 1, 2025) Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects. International Journal of Chemistry and Technology 9 1 147–152.

IEEE

[1]C. Bal, “Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects”, Int. J. Chem. Technol., vol. 9, no. 1, pp. 147–152, June 2025, doi: 10.32571/ijct.1668272.

ISNAD

Bal, Celal. “Biological Activities of Leucoagaricus Leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects”. International Journal of Chemistry and Technology 9/1 (June 1, 2025): 147-152. https://doi.org/10.32571/ijct.1668272.

JAMA

1.Bal C. Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects. Int. J. Chem. Technol. 2025;9:147–152.

MLA

Bal, Celal. “Biological Activities of Leucoagaricus Leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects”. International Journal of Chemistry and Technology, vol. 9, no. 1, June 2025, pp. 147-52, doi:10.32571/ijct.1668272.

Vancouver

1.Celal Bal. Biological Activities of Leucoagaricus leucothites Mushroom: Evaluation of Antioxidant, Anticholinesterase and Antiproliferative Effects. Int. J. Chem. Technol. 2025 Jun. 1;9(1):147-52. doi:10.32571/ijct.1668272

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https://doi.org/10.3390/molecules30163317