Research Article

Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells

Number: 11 November 7, 2026
EN

Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells

Abstract

Silver nanoparticles (Ag NPs) were synthesized using Salvia officinalis, Mentha piperita, and Thymus vulgaris extracts through a green synthesis approach, and their cytotoxic effects against MCF-7 breast cancer cells were evaluated. Ag NPs were characterized by UV–Vis spectroscopy, SEM–EDX, FT-IR, and ImageJ-based particle size analysis. Cytotoxicity was evaluated by MTT assay at 25, 50, and 100 µg ml⁻¹. UV–Vis spectra showed characteristic surface plasmon resonance peaks at 420–450 nm, confirming Ag NP formation. SEM and ImageJ analyses revealed predominantly spherical nanoparticles with mean sizes of 23.5 ± 9.2, 51.8 ± 17.6, and 59.9 ± 30.0 nm for S. officinalis, M. piperita, and T. vulgaris-derived Ag NPs, respectively. All preparations exhibited concentration-dependent cytotoxicity. At 100 µg ml⁻¹, S. officinalis-derived Ag NPs showed the highest cytotoxicity (90.82%), followed by T. vulgaris (54.41%) and M. piperita (45.62%) (p < 0.001). These findings demonstrate plant-dependent differences in Ag NP characteristics and cytotoxic activity against MCF-7 cells.

Keywords

Supporting Institution

This study was supported by the Scientific and Technological Research Council of Türkiye (TUBITAK) under the 2209-B Industry-Oriented Undergraduate Research Projects Support Program (Project No. 1139B412302052).

Project Number

Project No. 1139B412302052

Ethical Statement

Ethical approval was not required for this study, as no human participants or animals were involved.

Thanks

The authors acknowledge Gazi University Basic and Engineering Sciences Central Laboratory Application and Research Center (GUTMAM) for providing support with SEM analysis. The authors also acknowledge the Scientific and Technological Research Council of Türkiye (TUBITAK) for supporting the associated undergraduate research project under the 2209-B Industry-Oriented Undergraduate Research Projects Support Programme.

References

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other), Materials Engineering (Other)

Journal Section

Research Article

Publication Date

November 7, 2026

Submission Date

July 25, 2026

Acceptance Date

October 14, 2026

Published in Issue

Year 2026 Number: 11

APA
Yiyit Doğan, S., & Genç, E. (2026). Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells. International Journal of Chemistry and Technology, 11, 1-9. https://doi.org/10.32571/ijct.2001180
AMA
1.Yiyit Doğan S, Genç E. Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells. Int. J. Chem. Technol. 2026;(11):1-9. doi:10.32571/ijct.2001180
Chicago
Yiyit Doğan, Sema, and Eray Genç. 2026. “Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells”. International Journal of Chemistry and Technology, nos. 11: 1-9. https://doi.org/10.32571/ijct.2001180.
EndNote
Yiyit Doğan S, Genç E (November 1, 2026) Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells. International Journal of Chemistry and Technology 11 1–9.
IEEE
[1]S. Yiyit Doğan and E. Genç, “Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells”, Int. J. Chem. Technol., no. 11, pp. 1–9, Nov. 2026, doi: 10.32571/ijct.2001180.
ISNAD
Yiyit Doğan, Sema - Genç, Eray. “Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells”. International Journal of Chemistry and Technology. 11 (November 1, 2026): 1-9. https://doi.org/10.32571/ijct.2001180.
JAMA
1.Yiyit Doğan S, Genç E. Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells. Int. J. Chem. Technol. 2026;:1–9.
MLA
Yiyit Doğan, Sema, and Eray Genç. “Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells”. International Journal of Chemistry and Technology, no. 11, Nov. 2026, pp. 1-9, doi:10.32571/ijct.2001180.
Vancouver
1.Sema Yiyit Doğan, Eray Genç. Green-Synthesized Silver Nanoparticles from Medicinal Plants and Their Cytotoxic Activity Against MCF-7 Breast Cancer Cells. Int. J. Chem. Technol. 2026 Nov. 1;(11):1-9. doi:10.32571/ijct.2001180