Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells

Abstract

Prostate cancer is caused by uncontrolled growth of cells in the prostate gland. The aim of this study was to determine the cytotoxic activity of titanium dioxide (TiO₂) and zinc oxide (ZnO) nanoparticles (NPs) and TiO₂ + ZnO nanocomposite (NC) in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell line (L-929). In the study, TiO₂ and ZnO NPs and TiO₂ + ZnO NC were synthesized. Cytotoxic activities of NC and NPs was then analyzed in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell lines (L-929) using the MTT method. TiO₂, ZnO and TiO₂ + ZnO IC₅₀ values were determined in DU-145 and L-929 cell cells (n = 6). TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).

Keywords

• Prostate cancer,Du-145,L-929,TiO2/ZnO

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