Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells

Year 2019, Volume: 3 Issue: 2, 113 - 120, 31.12.2019

Ayca Tas , Nese Keklikcioglu Cakmak , Tugba Agbektas Yavuz Silig

https://doi.org/10.32571/ijct.613536

Cited By: 7

Abstract

Prostate cancer is caused by uncontrolled growth of cells in the
prostate gland. The aim of this study was to determine the cytotoxic activity
of titanium dioxide (TiO₂) and zinc oxide (ZnO) nanoparticles (NPs)
and TiO₂ + ZnO nanocomposite (NC) in human prostate cancer cell line
(DU-145) and healthy mouse fibroblast cell line (L-929). In the study, TiO₂
and ZnO NPs and TiO₂ + ZnO NC were synthesized. Cytotoxic activities
of NC and NPs was then analyzed in human prostate cancer cell line (DU-145) and
healthy mouse fibroblast cell lines (L-929) using the MTT method. TiO₂,
ZnO and TiO₂ + ZnO IC₅₀ values were determined in DU-145
and L-929 cell cells (n = 6). TiO2 + ZnO NC in the Du-145 cell line was found
as the most active, having statistically significant (***p < 0.0001, **p ˂
0.001 and **p ˂ 0.01).

Keywords

Prostate cancer, Du-145, L-929, TiO2/ZnO

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