The anticancer activity of chalcone compounds against human prostate carcinoma cell and human colon colorectal adenocarcinoma

Year 2021, Volume: 5 Issue: 1, 52 - 58, 30.06.2021

Bedriye Seda Kurşun Aktar Ayşe Şahin Yağlıoğlu Emine Elçin Oruç-emre

https://doi.org/10.32571/ijct.910580

Abstract

The anticancer activities 3-(substituted phenyl)-1-[4-(morpholine-4-yl)phenyl]prop-2-en-1-one derivatives were investigated against PC3 (Human Prostate Carcinoma Cell) and HT29 (Human colon colorectal adenocarcinoma) cell lines. The anticancer activity tests were performed by the BrdU ELISA method. 5-Fluorouracil (5-FU) was used as standard compound. Compound 1-7 (except Compound 3) were determined to have higher anticancer activity than 5-FU aganist PC3 cancer cells. IC50 values of the Compounds 1-7 against PC3 cancer cells were 2.53±0.02 µM; 4.40±0.03 µM; 4.36±0.03 µM; 1.76±0.02 µM; 1.78±0.03 µM; 2.31±0.03 µM, respectively.

Keywords

HT29, PC3, Chalcone, 5-Fluorouracil, Fluor atom, anticancer activity

Supporting Institution

Gaziantep University Scientific Research Projects Governing Unit (BAPYB) (Project no: FEF.14.01), Turkey

Project Number

Project no: FEF.14.01

Thanks

This study was supported by the Gaziantep University Scientific Research Projects Governing Unit (BAPYB) (Project no: FEF.14.01), Turkey

References

• Reference1: Prof. Dr. İbrahim Demirtaş ([e-mail]) Reference2: Prof. Dr. Nurettin Yaylı (nurettin [e-mail] )