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Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri

Yıl 2022, Cilt: 6 Sayı: 1, 7 - 14, 06.07.2022

Bedriye Seda Kurşun Aktar Yusuf Sıcak Emine Elçin Oruç-emre

https://doi.org/10.32571/ijct.1003871
Cited By: 2

Öz

Kaynakça

  • Ağalar, H.G. Pharmacognostical Investigations on Arum italicum Miller. Ph.D. Dissertation, Anadolu University, Eskişehir, 2016.
  • Hartman, R.E. Actions of bioactive phytochemicals in cell function and Alzheimer’s Disease pathology. L. Packer, H. Sies, M. Eggersdorfer, E. Cadenas Ed.; Cadenas Micronutrients and Brain Health. 2009; pp 225. CRC Press.
  • Kuşman, K. Isolation of bioactive glaucine and other alkaloids from some glaucium species grown in Turkey and quantification with high performance liquid chromatography. Ph.D. Dissertation, İstanbul University, İstanbul, 2018.
  • I. Parveen, M.D; Threadgill, J.M; Moorby, A. J Agric Food Chem, 2010, 58, 1371-1382.
  • Sıcak, Y.; Büyüksakallı, H.; Malkoçoğlu, S.; Özler, M. A.; Öztürk, M. J. Ong. Chem. Res., 2017, 3(1), 22-31.
  • Kim, Y.J.; Uyama, H. Cell Mol. Life Sci. 2005, 62, 1707-1723.
  • Modolo, L.V.; Souza, A.X.; Horta, L.P.; Araujo, D.P.; Fátima, A. J. Adv. Res. 2015, 6, 35-44.
  • Sıcak, Y.; Nadeem, S.; Aktar, B. S. K.; Emre, E. E. O.; Öztürk, M.; İyidoğan, A. K.; Demirtaş, İ. J. Ong. Chem. Res. 2017, 3(1), 32-49.
  • Dimmock, J.R.; Elias, D. W.; Beazely, M. A.; Kandepu, N. M. Bioactivities of chalcones, Curr. Med. Chem. 1999, 6, 1125-1149.
  • Detsi, A.; Majdalani, M.; Kontogiorgis, C.A.; Hadjipavlou-Litin, D.; Kefalas, P. Bioorg. Med. Chem. 2009, 17, 8073-8085.
  • Kurşun-Aktar, B. S.; Oruç-Emre, E. E.; Karaküçük-İyi̇doğan, A., Yağlioğlu, A. Ş.; Demi̇rtaş, İ.; Teki̇n, Ş. J. Res. Pharm. 2017, 21(4), 949-960.
  • Fringuelli, F.; Pizzo, F.; Vittoriani, C.; Vaccacio, L. Chem. Comm. 2004, 23, 2756-2757.
  • Selepe, M.A.; Heerden, F.R.V. Molecules. 2013, 18, 4739-4765.
  • Xu, L.; Li, L.; Xia, C.; Zhao, P. Helv. Chim. Acta. 2014, 87, 3080-3084.
  • Wu, X.F.; Neumann, H.; Spannenberg, A.; Schulz, T.; Jiao, H.J.; Beller, M. J. Am. Chem. Soc.. 2010, 132, 14596-14602.
  • Chen, M. S.; Christensen, B.; Blom, J.; Lemmich, E.; Nadelmann, L.; Fich, K.; Theander, T. G.; Kharazmi, A.; Licochalcone A. Antimicrob. Agents Chemother. 1993, 37, 2550-2556.
  • Kakati, D.; Sarma, J.C. Chem. Cent. 2011, 5, 8.
  • Rueping, M.; Bootwicha, T.; Baars, H.; Sugiono, E.Beilstein J. Org. Chem. 2011, 7, 1680-1687.
  • Schramm, O.G. Multi-component Heterocycle Syntheses Based upon Sonogashira Coupling Isomerization (Dissertation), Ruprecht-Karls University, Heidelberg, Germany, 2006.
  • Bukhari, S. N. A.; Butt, A.M.; Amjad, M.W.; Ahmad, B. A.; Shah, V.H.; Trivedi A.R. Pak. J .Pharm. Sci. 2013,16, 1368-1372.
  • Kumar, A.; Sharma, S.; Tripathi, V.D.; Srivastava, S. Tetrahedron. 2010, 66, 9445-9449.
  • Zhao, L.; Jin, H.; Sun, L.; Piao, H.; Quan, Z. Bioorg. Med. Chem Lett. 2005, 15, 5027-5029.
  • Mahapatra, D.K.; Asati, V.; Bharti, S.K. Eur. J. Med. Chem. 2015,92, 839-865.
  • Zhang, B.; Lai, Y.; Li, Y.; Shu, N.; Wang, Y.; Li, Y.; Chen, Z. Eur. J. Pharmacol. 2018, 57-67.
  • Lee, Y. S.; Lim, S. S.; Shin, K. H.; Ohuchi, Y. S. K.; Jung, S. H. Biol. Pharm. Bul. 2006, 29, 1028-1031.
  • Rizvi, S. U. F.; Siddiqui, H. L.; Johns, M.; Detorio, M.; Schinazi. R. F. Med. Chem. Res. 2012, 21, 3741-3749.
  • Israf, D. A.; Khaizurin, T. A.; Syahida, A.; Lajis, N. H.; Khozirah, S.Mol. Immunol. 2007, 44, 673-679.
  • Kim, D. W.; Curtis-Long, M. J.; Yuk, H. J.; Wang, Y.; Song, Y. H.; Jeong, S. H.; Park, K. H. 2014, Food Chem. 153, 20-27.
  • Yamamoto, T.; Yoshimura, M.; Yamaguchi, F.; Kouchi, T.; Tsuji, R.; Saito, M.; Obata, A.; Kikuchi, M. Biosci. Biotechnol. Biochem. 2004, 68, 1706-1711.
  • Aoki, N.; Muko, M.; Ohta, E.; Ohta, S. J. Nat. Prod. 2008, 71, 1308-1310.
  • Birari, R. B.; Gupta, S.; Mohan, C. G.; Bhutani, K. K. Phytomedicine. 2011, 18, 795- 801.
  • Sashidhara, K.V.; Palnati, G. R.; Sonkar, R.; Avula, S. R.; Awasthi, C.; Bhatia, G. 2013, Eur. J. Med. Chem, 64, 422-431.
  • Mascarello, A.; Chiaradia, L. D.; Vernal, J.; Villarino, A.; Guido, R. V.; Perizzolo, P.; Poirier, V.; Wong, D.; Martins, P. G.; Nunes, R. J.; Yunes, R. A.; Andricopulo, A. D.; Av-Gay, Y.; Terenzi, H. Bioorg. Med. Chem. 2010, 18, 3783-3789.
  • Sashidhara, K.V.; Rao, K.B.; Kushwaha, V.; Modukuri, R.K.; Verma, R.; Murthy, P.K. Eur. J. Med. Chem. 2014, 81, 473-480.
  • Wang, M.; Xu, S.; Wu, C.; Liu, X.; Tao, H.; Huang, Y.; Liu, Y.; Zheng, P.; Zhu, W. 2016, Bioorg. Med. Chem Lett. 26, 5450–5454.
  • Tomar, V.; Bhattacharjee, G.; Rajakumar, S.; Srivastava,K.; Puri, S.K. 2010, Eur. J. Med. Chem. 45, 745-751.
  • Chen, M. S.; Christensen, B.; Blom, J.; Lemmich, E.; Nadelmann, L.; Fich, K.; Theander, T. G.; Kharazmi, A.; Licochalcone A. Antimicrob. Agents Chemother. 1993, 37, 2550-2556.
  • Abdullah, M. I.; Mahmood, A.; Madni, M.; Masood, S.; Kashif, M. Bioorg. Chem. 2014, 54, 31-37.
  • Lahtchev, K. V.; Batovska, D. I.; Parushev, S. P.; Ubiyvovk, V. M.; Sibirny, A. A. Eur. J. Med. Chem. 2008, 43, 2220-2228.
  • Sashidhara, K.V.; Avula, S.R.; Mishra, V.; Palnati, G.R.; Singh, L.R.; Singh, N.; Chhonker, Y.S.; Swamy, P.; Bhatta, R.S.; Palit, G. Eur. J. Med. Chem, 2015, 89, 638-653.
  • Bail, J.L.; Pouget, C.; Fagnere, C.; Basly, J.; Chulia, A.; Habrioux, G. Life Sci. 2001, 68, 751-761.
  • Luo, Y.; Song, R.; Li, Y.; Zhang, S.; Liu, Z.J.; Fu, J.; Zhu, H.L. Bioorg. Med. Chem Lett. 2012, 22, 3039-3043
  • Cho, S.; Kim, S.; Jin, Z.; Yang, H.; Han, D. N.; Baek, I.; Jo, J.; Cho, C.W.; Park, J.H.; Shimizu, M.; Jin, Y.H.Biochem. Biophys. Res. Commun. 2011, 413, 637-642.
  • Jamal, H.; Ansari, W.H.; Rizvi, S.J. Fund. Clin. Pharmacol. 2008, 22, 673-681.
  • Sato, Y.; He, J.; Nagai, H.; Tani, T.; Akao, T. Biol. Pharm. Bull. 2007, 30, 145-149.
  • Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Correa, R.; Nunes, R. J.; CechinelFilho, V. Molecules. 2007, 12, 896-906.
  • Ortolan, X.R.; Fenner, B.P.; Mezadri, T.J.; Tames, D.R.; Correa, R.; Campos Buzzi, F. Craniomaxillofacial surgery. 2014, 42, 520-524.
  • Kursun Aktar, B.S.; Oruç-Emre, E.E.; Demirtas¸ I., Sahin Yaglioglu, A.; Guler, C.; Adem, S.; Karaküçük Iyidogan, A. J. Mol. Struct. 2017, 1149, 632-639.
  • Tao, X. X.; Duan, Y. T.; Chen, L. W.; Tang, D. J.; Yang, M. R.; Wang, P. F.; Xu, C.; Zhu, H. L. Bioorg. Med. Chem Lett. 2016, 677-683.
  • Ellan, G.L.; Courtney, K.D.; Andres, V.; Featherstone, R.M. Biochem Pharmacol Behaivor, 1961, 7, 88-95.
  • Hearing, V. J. Methods in Enzymology. Academic Press: New York, 1987, 142: 154-165.
  • Weaterburn, M.W. Analy Chem. 1967, 39: 971-974.
  • Daina,A.; Michielin, O.; Zoete, V. Scientific Reports, 2017, 7(), 42717.
  • Molsoft molecules in silico. http://moloft.com/mprop (accessed September 9, 2021)
  • Sıcak Y. Med. Chem. Res. 2021, 30(8), 1557-1568.
  • Sıcak, Y. Turk J Chem. 2021, DOI: 10.3906/kim-2107-27

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Yıl 2022, Cilt: 6 Sayı: 1, 7 - 14, 06.07.2022

Bedriye Seda Kurşun Aktar Yusuf Sıcak Emine Elçin Oruç-emre

https://doi.org/10.32571/ijct.1003871
Cited By: 2

Öz

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

Anahtar Kelimeler

Chalcone Anticholinesterase activity Tyrosinase inhibitory activity Urease inhibitory activity

Kaynakça

  • Ağalar, H.G. Pharmacognostical Investigations on Arum italicum Miller. Ph.D. Dissertation, Anadolu University, Eskişehir, 2016.
  • Hartman, R.E. Actions of bioactive phytochemicals in cell function and Alzheimer’s Disease pathology. L. Packer, H. Sies, M. Eggersdorfer, E. Cadenas Ed.; Cadenas Micronutrients and Brain Health. 2009; pp 225. CRC Press.
  • Kuşman, K. Isolation of bioactive glaucine and other alkaloids from some glaucium species grown in Turkey and quantification with high performance liquid chromatography. Ph.D. Dissertation, İstanbul University, İstanbul, 2018.
  • I. Parveen, M.D; Threadgill, J.M; Moorby, A. J Agric Food Chem, 2010, 58, 1371-1382.
  • Sıcak, Y.; Büyüksakallı, H.; Malkoçoğlu, S.; Özler, M. A.; Öztürk, M. J. Ong. Chem. Res., 2017, 3(1), 22-31.
  • Kim, Y.J.; Uyama, H. Cell Mol. Life Sci. 2005, 62, 1707-1723.
  • Modolo, L.V.; Souza, A.X.; Horta, L.P.; Araujo, D.P.; Fátima, A. J. Adv. Res. 2015, 6, 35-44.
  • Sıcak, Y.; Nadeem, S.; Aktar, B. S. K.; Emre, E. E. O.; Öztürk, M.; İyidoğan, A. K.; Demirtaş, İ. J. Ong. Chem. Res. 2017, 3(1), 32-49.
  • Dimmock, J.R.; Elias, D. W.; Beazely, M. A.; Kandepu, N. M. Bioactivities of chalcones, Curr. Med. Chem. 1999, 6, 1125-1149.
  • Detsi, A.; Majdalani, M.; Kontogiorgis, C.A.; Hadjipavlou-Litin, D.; Kefalas, P. Bioorg. Med. Chem. 2009, 17, 8073-8085.
  • Kurşun-Aktar, B. S.; Oruç-Emre, E. E.; Karaküçük-İyi̇doğan, A., Yağlioğlu, A. Ş.; Demi̇rtaş, İ.; Teki̇n, Ş. J. Res. Pharm. 2017, 21(4), 949-960.
  • Fringuelli, F.; Pizzo, F.; Vittoriani, C.; Vaccacio, L. Chem. Comm. 2004, 23, 2756-2757.
  • Selepe, M.A.; Heerden, F.R.V. Molecules. 2013, 18, 4739-4765.
  • Xu, L.; Li, L.; Xia, C.; Zhao, P. Helv. Chim. Acta. 2014, 87, 3080-3084.
  • Wu, X.F.; Neumann, H.; Spannenberg, A.; Schulz, T.; Jiao, H.J.; Beller, M. J. Am. Chem. Soc.. 2010, 132, 14596-14602.
  • Chen, M. S.; Christensen, B.; Blom, J.; Lemmich, E.; Nadelmann, L.; Fich, K.; Theander, T. G.; Kharazmi, A.; Licochalcone A. Antimicrob. Agents Chemother. 1993, 37, 2550-2556.
  • Kakati, D.; Sarma, J.C. Chem. Cent. 2011, 5, 8.
  • Rueping, M.; Bootwicha, T.; Baars, H.; Sugiono, E.Beilstein J. Org. Chem. 2011, 7, 1680-1687.
  • Schramm, O.G. Multi-component Heterocycle Syntheses Based upon Sonogashira Coupling Isomerization (Dissertation), Ruprecht-Karls University, Heidelberg, Germany, 2006.
  • Bukhari, S. N. A.; Butt, A.M.; Amjad, M.W.; Ahmad, B. A.; Shah, V.H.; Trivedi A.R. Pak. J .Pharm. Sci. 2013,16, 1368-1372.
  • Kumar, A.; Sharma, S.; Tripathi, V.D.; Srivastava, S. Tetrahedron. 2010, 66, 9445-9449.
  • Zhao, L.; Jin, H.; Sun, L.; Piao, H.; Quan, Z. Bioorg. Med. Chem Lett. 2005, 15, 5027-5029.
  • Mahapatra, D.K.; Asati, V.; Bharti, S.K. Eur. J. Med. Chem. 2015,92, 839-865.
  • Zhang, B.; Lai, Y.; Li, Y.; Shu, N.; Wang, Y.; Li, Y.; Chen, Z. Eur. J. Pharmacol. 2018, 57-67.
  • Lee, Y. S.; Lim, S. S.; Shin, K. H.; Ohuchi, Y. S. K.; Jung, S. H. Biol. Pharm. Bul. 2006, 29, 1028-1031.
  • Rizvi, S. U. F.; Siddiqui, H. L.; Johns, M.; Detorio, M.; Schinazi. R. F. Med. Chem. Res. 2012, 21, 3741-3749.
  • Israf, D. A.; Khaizurin, T. A.; Syahida, A.; Lajis, N. H.; Khozirah, S.Mol. Immunol. 2007, 44, 673-679.
  • Kim, D. W.; Curtis-Long, M. J.; Yuk, H. J.; Wang, Y.; Song, Y. H.; Jeong, S. H.; Park, K. H. 2014, Food Chem. 153, 20-27.
  • Yamamoto, T.; Yoshimura, M.; Yamaguchi, F.; Kouchi, T.; Tsuji, R.; Saito, M.; Obata, A.; Kikuchi, M. Biosci. Biotechnol. Biochem. 2004, 68, 1706-1711.
  • Aoki, N.; Muko, M.; Ohta, E.; Ohta, S. J. Nat. Prod. 2008, 71, 1308-1310.
  • Birari, R. B.; Gupta, S.; Mohan, C. G.; Bhutani, K. K. Phytomedicine. 2011, 18, 795- 801.
  • Sashidhara, K.V.; Palnati, G. R.; Sonkar, R.; Avula, S. R.; Awasthi, C.; Bhatia, G. 2013, Eur. J. Med. Chem, 64, 422-431.
  • Mascarello, A.; Chiaradia, L. D.; Vernal, J.; Villarino, A.; Guido, R. V.; Perizzolo, P.; Poirier, V.; Wong, D.; Martins, P. G.; Nunes, R. J.; Yunes, R. A.; Andricopulo, A. D.; Av-Gay, Y.; Terenzi, H. Bioorg. Med. Chem. 2010, 18, 3783-3789.
  • Sashidhara, K.V.; Rao, K.B.; Kushwaha, V.; Modukuri, R.K.; Verma, R.; Murthy, P.K. Eur. J. Med. Chem. 2014, 81, 473-480.
  • Wang, M.; Xu, S.; Wu, C.; Liu, X.; Tao, H.; Huang, Y.; Liu, Y.; Zheng, P.; Zhu, W. 2016, Bioorg. Med. Chem Lett. 26, 5450–5454.
  • Tomar, V.; Bhattacharjee, G.; Rajakumar, S.; Srivastava,K.; Puri, S.K. 2010, Eur. J. Med. Chem. 45, 745-751.
  • Chen, M. S.; Christensen, B.; Blom, J.; Lemmich, E.; Nadelmann, L.; Fich, K.; Theander, T. G.; Kharazmi, A.; Licochalcone A. Antimicrob. Agents Chemother. 1993, 37, 2550-2556.
  • Abdullah, M. I.; Mahmood, A.; Madni, M.; Masood, S.; Kashif, M. Bioorg. Chem. 2014, 54, 31-37.
  • Lahtchev, K. V.; Batovska, D. I.; Parushev, S. P.; Ubiyvovk, V. M.; Sibirny, A. A. Eur. J. Med. Chem. 2008, 43, 2220-2228.
  • Sashidhara, K.V.; Avula, S.R.; Mishra, V.; Palnati, G.R.; Singh, L.R.; Singh, N.; Chhonker, Y.S.; Swamy, P.; Bhatta, R.S.; Palit, G. Eur. J. Med. Chem, 2015, 89, 638-653.
  • Bail, J.L.; Pouget, C.; Fagnere, C.; Basly, J.; Chulia, A.; Habrioux, G. Life Sci. 2001, 68, 751-761.
  • Luo, Y.; Song, R.; Li, Y.; Zhang, S.; Liu, Z.J.; Fu, J.; Zhu, H.L. Bioorg. Med. Chem Lett. 2012, 22, 3039-3043
  • Cho, S.; Kim, S.; Jin, Z.; Yang, H.; Han, D. N.; Baek, I.; Jo, J.; Cho, C.W.; Park, J.H.; Shimizu, M.; Jin, Y.H.Biochem. Biophys. Res. Commun. 2011, 413, 637-642.
  • Jamal, H.; Ansari, W.H.; Rizvi, S.J. Fund. Clin. Pharmacol. 2008, 22, 673-681.
  • Sato, Y.; He, J.; Nagai, H.; Tani, T.; Akao, T. Biol. Pharm. Bull. 2007, 30, 145-149.
  • Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Correa, R.; Nunes, R. J.; CechinelFilho, V. Molecules. 2007, 12, 896-906.
  • Ortolan, X.R.; Fenner, B.P.; Mezadri, T.J.; Tames, D.R.; Correa, R.; Campos Buzzi, F. Craniomaxillofacial surgery. 2014, 42, 520-524.
  • Kursun Aktar, B.S.; Oruç-Emre, E.E.; Demirtas¸ I., Sahin Yaglioglu, A.; Guler, C.; Adem, S.; Karaküçük Iyidogan, A. J. Mol. Struct. 2017, 1149, 632-639.
  • Tao, X. X.; Duan, Y. T.; Chen, L. W.; Tang, D. J.; Yang, M. R.; Wang, P. F.; Xu, C.; Zhu, H. L. Bioorg. Med. Chem Lett. 2016, 677-683.
  • Ellan, G.L.; Courtney, K.D.; Andres, V.; Featherstone, R.M. Biochem Pharmacol Behaivor, 1961, 7, 88-95.
  • Hearing, V. J. Methods in Enzymology. Academic Press: New York, 1987, 142: 154-165.
  • Weaterburn, M.W. Analy Chem. 1967, 39: 971-974.
  • Daina,A.; Michielin, O.; Zoete, V. Scientific Reports, 2017, 7(), 42717.
  • Molsoft molecules in silico. http://moloft.com/mprop (accessed September 9, 2021)
  • Sıcak Y. Med. Chem. Res. 2021, 30(8), 1557-1568.
  • Sıcak, Y. Turk J Chem. 2021, DOI: 10.3906/kim-2107-27
Toplam 56 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Mühendislik
Bölüm Makale
Yazarlar

Bedriye Seda Kurşun Aktar 0000-0002-1492-3266

Yusuf Sıcak 0000-0003-2339-5837

Emine Elçin Oruç-emre 0000-0001-6840-9660

Yayımlanma Tarihi 6 Temmuz 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 1

Kaynak Göster

APA Kurşun Aktar, B. S., Sıcak, Y., & Oruç-emre, E. E. (2022). Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. International Journal of Chemistry and Technology, 6(1), 7-14. https://doi.org/10.32571/ijct.1003871
AMA Kurşun Aktar BS, Sıcak Y, Oruç-emre EE. Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. Int. J. Chem. Technol. Temmuz 2022;6(1):7-14. doi:10.32571/ijct.1003871
Chicago Kurşun Aktar, Bedriye Seda, Yusuf Sıcak, ve Emine Elçin Oruç-emre. “Synthesis and Biological Activities of New Hybrid Chalcones With Benzoic Acid Ring”. International Journal of Chemistry and Technology 6, sy. 1 (Temmuz 2022): 7-14. https://doi.org/10.32571/ijct.1003871.
EndNote Kurşun Aktar BS, Sıcak Y, Oruç-emre EE (01 Temmuz 2022) Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. International Journal of Chemistry and Technology 6 1 7–14.
IEEE B. S. Kurşun Aktar, Y. Sıcak, ve E. E. Oruç-emre, “Synthesis and biological activities of new hybrid chalcones with benzoic acid ring”, Int. J. Chem. Technol., c. 6, sy. 1, ss. 7–14, 2022, doi: 10.32571/ijct.1003871.
ISNAD Kurşun Aktar, Bedriye Seda vd. “Synthesis and Biological Activities of New Hybrid Chalcones With Benzoic Acid Ring”. International Journal of Chemistry and Technology 6/1 (Temmuz 2022), 7-14. https://doi.org/10.32571/ijct.1003871.
JAMA Kurşun Aktar BS, Sıcak Y, Oruç-emre EE. Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. Int. J. Chem. Technol. 2022;6:7–14.
MLA Kurşun Aktar, Bedriye Seda vd. “Synthesis and Biological Activities of New Hybrid Chalcones With Benzoic Acid Ring”. International Journal of Chemistry and Technology, c. 6, sy. 1, 2022, ss. 7-14, doi:10.32571/ijct.1003871.
Vancouver Kurşun Aktar BS, Sıcak Y, Oruç-emre EE. Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. Int. J. Chem. Technol. 2022;6(1):7-14.

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