Polymer – flufenamic acid delivery systems for injured skin

Yıl 2022, Cilt: 6 Sayı: 2, 114 - 121, 31.12.2022

Minodora Maria Marın Mihaela Violeta Ghıca Alpaslan Kaya Denisa Ioana Udeanu Madalina Albu Kaya Cristina-elena Dınu-pîrvu Lăcrămioara Popa Valentina Anuța Razvan Mihai Prısada

https://doi.org/10.32571/ijct.1135548

Öz

Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.

Anahtar Kelimeler

Collagen sponges, microcapsules, flufenamic acid, kinetic release, wound healing

Destekleyen Kurum

UEFISCDI

Proje Numarası

PED 160/03.01.2017,code PN-III-P2-2.1-PED-2016-0813

Teşekkür

This work was in the frame of PN-III-Experimental Demonstration Project

Kaynakça

• Greenhalgh, D.G. Management of Burns. N. Engl. J. Med., 2019, 380, 2349–2359.
• Nessler, M.; Chrapusta, A. Leczenie Ran. 2013, 10, 47–52.
• Markiewicz-Gospodarek, A.; Kozioł, M.; Tobiasz, M.; Baj, J.; Radzikowska-Büchner, E.; Przekora, A. Int. J. Environ. Res. Public Health, 2022, 19, 1338.
• Albu, M.G.; Titorencu, I.; Ghica, M.V. Collagen-Based Drug Delivery Systems for Tissue Engineering. In Biomaterials Applications for Nanomedicine; InTech, 2011.
• Harley, B.A.; Lynn, A.K.; Wissner-Gross, Z.; Bonfield, W.; Yannas, I. V.; Gibson, L.J. J. Biomed. Mater. Res. Part A, 2009, 9999A.
• Healy, K.E.; Rezania, A.; Stile, R.A. Ann. N. Y. Acad. Sci., 1999, 875, 24–35.
• Alipal, J.; Mohd Pu’ad, N.A.S.; Lee, T.C.; Nayan, N.H..; Sahari, N.; Basri, H.; Idris, M.I.; Abdullah, H.Z. Mater. Today Proc., 2021, 42, 240–250.
• Kumosa, L.S.; Zetterberg, V.; Schouenborg, J. Acta Biomater.,2018, 65, 137–149.
• Ma, K.; Cai, X.; Zhou, Y.; Wang, Y.; Jiang, T. Macromol. Biosci., 2017, 17, 1600130.
• Sosnik, A. ISRN Pharm., 2014, 2014, 1–17.
• Rinaudo, M. Polym. Int., 2008, 57, 397–430.
• Smidsrod, O.; Skjakbrk, G.Trends Biotechnol., 1990, 8, 71–78.
• Gasperini, L.; Mano, J.F.; Reis, R.L. J. R. Soc. Interface, 2014, 11, 20140817.
• Choi, H.-G.; Kim, C.-K. J. Control. Release, 2000, 68, 397–404.
• Díaz-Montes, E. Polysaccharides, 2021, 2, 554–565.
• Heinze, T.; Liebert, T.; Heublein, B.; Hornig, S. Functional Polymers Based on Dextran. In Polysaccharides II; Springer Berlin Heidelberg; pp. 199–291, 2006.
• Naessens, M.; Cerdobbel, A.; Soetaert, W.; Vandamme, E.J. J. Chem. Technol. Biotechnol., 2005, 80, 845–860.
• Rahman, M.S.; Hasan, M.S.; Nitai, A.S.; Nam, S.; Karmakar, A.K.; Ahsan, M.S.; Shiddiky, M.J.A.; Ahmed, M.B. Polymers (Basel)., 2021, 13, 1345.
• Shu, W.; Wang, Y.; Zhang, X.; Li, C.; Le, H.; Chang, F. Front. Bioeng. Biotechnol., 2021, 9.788461.
• Malinovskaja-Gomez, K.; Labouta, H.I.; Schneider, M.; Hirvonen, J.; Laaksonen, T. Eur. J. Pharm. Sci., 2016, 89, 154–162.
• Dinescu, S.; Ignat, S.; Lazar, A.; Marin, S.; Danilă, E.; Marin, M.M.; Udeanu, D.I.; Ghica, M.V.; Albu Kaya, M.G.; Costache, M. J. Immun. Res., 2019, 4513108.
• Albu, M. G.Collagen Gels and Matrices for Biomedical Applications, Lambert Academic Publishing, Saarbrücken, 2011.
• Ghica, M.V.; Albu, M.G.; Popa, L.; Moisescu, Ș., Pharmazie, 2013, 68(5), 340-348.
• Marin, M.M.;Albu Kaya, M.G.;Ghica, M.V.;Dănilă, E.;Coară, G.;Popa, L.; Chelaru, C.;Kaya, D.A.;Anuța, V.; Dinu-Pîrvu, C.E.;Cristescu, I. Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration, Proceedings of the 8thInternationalConferenceonAdvancedMaterialsandSystems (ICAMS),Bucharest, 1-3 October 2020, p. 201-206, 2020.
• Udeanu, D.I.; Albu Kaya, M.G.; Ghica, M.V.; Marin, S.; Marin, M.M.; Kaya, D.A.; Popa, L., Dinu-Pîrvu, C.E. Farmacia,2018, 66(5), 783-790.
• Ghica, M.V.; Albu Kaya, M.G.; Udeanu, D.I.; Marin, M.M.; Marin, S.; Kaya, D.A.;Dinu-Pirvu, C.; Popa, L.; Danila, E. RO Patent 132850, October 29, 2021.