Case Report
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Santral Dev Hücreli Granüloma : 3 Vaka Raporu

Year 2024, Volume: 4 Issue: 2, 69 - 73, 30.08.2024
https://doi.org/10.61139/ijdor.1534452

Abstract

Santral dev hücreli granüloma nadir rastlanılan, benign fakat lokal agresif karakterli bir kemik tümörüdür. Lezyonlar yavaş büyüme gösterebildiği gibi hızlı seyir de gösterebilir. Genellikle ağrısız şişlikle karakterizedirler fakat hızlı ve yıkıcı bir şekilde büyüyen ve alveolar kemiği yıkıma uğratan vakalar da belirtilmiştir. Etiyolojisi tam olarak bilinmemektedir..Mandibula tutulumu maksillaya göre daha fazladır ve kadınlarda daha sık görülür. Genellikle çocukluk çağı ve genç erişkinlerde rastlanılır. Ayırıcı tanı radiküler kistler, odontojenik kistler, Brown tümörü ve fibröz displazi ile yapılır.Konservatif tedavi seçenekleri arasında intralezyonel stero-id, interferon ,kalsitonin uygulanması gösterilmektedir. Cerrahi tedavi ile tatminkar sonuçlar elde edilebilir. Bu olgu sunumunda , cerrahi olarak tedavi edilen üç adet mandibular santral dev hücreli granüloma olgusu sunulmuştur.

References

  • 1. Kumar KA, Humayun S, Kumar BP, Rao JB. Reparative giant cell granuloma of the maxilla. Ann Maxillofac Surg 2011;1(2):181-6.
  • 2. Babadağ DM, Karasu HA, Şahin M, Uyanık LO. [Central giant cell granuloma a case report]. A. Ü. Diş Hek Fak. Derg. 2006;33(1):59-62.
  • 3. Scully C. Oral & Maxillofacial Medicine The Basis of Diagnosis and Treatment. 3rd ed., China Elsevier Ltd; 2013.
  • 4. Pogrel MA. Benign Nonodontogenic Lesions of the Jaws. In: Ghali GE, editor. Peterson’s Principles of Oral and Maxillofacial Surgery. 2nd ed. London, BC Decker Inc; 2004. 603-604.
  • 5. Harorlı A. Ağız, Diş ve Çene Radyolojisi. 1st ed. İstanbul: Nobel Tıp Kitapevleri; 2014.
  • 6. Stuart C. White MJP. Oral Radiology Principles and Interpretation. 7th ed. St. Louis, Missouri; 2014.
  • 7. Sass SMG, Pinto MC. Giant cell reparative granuloma in the mandible. Braz J Otorhinolaryngol 2010;76(2):273
  • 8. Gökler A, Türkoğlu G, Taşkoparan G. Santral dev hücreli granüloma (central giant cell granuloma). K.B.B. ve Baş Boyun Cerrahisi Dergisi. 1994;2(1).
  • 9. Daroit NB, de Marco RG, Sant’Anna Filho M, Fritscher GG. The challenge in the treatment of central giant cell granuloma – What is the best approach? J Oral Maxillofac Surg Med Pathol. 2017;29(2):122-128.
  • 10. Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol 1953;6:159-75.
  • 11. Allon DM, Anavi Y, Calderon S. Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107: 811-8.
  • 12. Yamaguchi T, Dorfman HD. Giant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 2001;9:189-200.
  • 13. Tosco P, Tanteri G, Iaquinta C, et al. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: a review of 18 cases. J Craniomaxillofac Surg 2009;37:380-7.
  • 14. Cohen MA, Hertzanu Y. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol 1988; 65:255-61.
  • 15. Triantafillidou K, Venetis G, Karakinaris G, Iordanidis F. Central Giant Cell Granuloma of the Jaws: A Clinical Study of 17 Cases and a Review of the Literature. Ann Otol Rhinol Laryngol. 2011;120(3):167-174.
  • 16. Ruggieri M, Pavone V, Polizzi A, et al. Unusual form of recurrent giant cell granuloma of the mandible and lower extremities in a patient with neurofibromatosis type 1.
  • 17. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:67-72.
  • 18. A, Türkoğlu G, Taşkoparan G. Santral dev hücreli granüloma. K.B.B. ve Baş Boyun Cerrahisi Dergisi. 1994;2(1).
  • 19. Vasconcelos RG, Vasconcelos MG, Queiroz LMG. Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment. J Bras Patol Med Lab 2013;49:446–52.
  • 20. Rather V, Dorfman HD. Giant cell reparative granuloma of the hand and foot bones. Clin Orthop 1990: 260: 251–8
  • 21. Shafer WG, Hine MK, Levy BM, eds.: A textbook of oral pathology. New York: Saunders, 1983: 146–9.
  • 22. Rosenberg AJWP, Bosschaart AN, Jacops JWG, Wirds JJ, Koole R. Calcitoninetherapie bij grote of recidiverende centrale reuzencelgranulomen van de onderkaak. Ned Tijdschr Geneeskd 1997: 141: 335–9.
  • 23. Van Damme PA, Mooren RECM. Differentiation of multiple giant cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism. Int J Oral Maxillofac Surg 1994: 23: 32–6.
  • 24. Harris M: Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 31:89, 1993.
  • 25. Kermer C, Millesi W, Watzke IM: Local injection of corticosteroids for central giant cell granuloma: A case report. Int J Oral Maxillofac Surg. 23:366, 1994

Central Giant Cell Granüloma : 3 Cases Report

Year 2024, Volume: 4 Issue: 2, 69 - 73, 30.08.2024
https://doi.org/10.61139/ijdor.1534452

Abstract

Central giant cell granuloma is a rare, benign but locally aggressive bone tumor. Le-sions may show slow growth or rapid progression. They are usually characterized by painless swelling, but cases of rapid and destructive growth and destruction of alveo-lar bone have also been reported. The etiology is unknown. The involvement of the mandible is more common than the maxilla and is more common in women. It is usu-ally seen in childhood and young adults. Differential diagnosis is made with radicular cysts, odontogenic cysts, Brown's tumor and fibrous dysplasia. Conservative treat-ment options include intralesional steroids, interferon, calcitonin. Satisfactory results can be obtained with surgical treatment. In this case report, three cases of mandibular central giant cell granuloma treated surgically are presented.

References

  • 1. Kumar KA, Humayun S, Kumar BP, Rao JB. Reparative giant cell granuloma of the maxilla. Ann Maxillofac Surg 2011;1(2):181-6.
  • 2. Babadağ DM, Karasu HA, Şahin M, Uyanık LO. [Central giant cell granuloma a case report]. A. Ü. Diş Hek Fak. Derg. 2006;33(1):59-62.
  • 3. Scully C. Oral & Maxillofacial Medicine The Basis of Diagnosis and Treatment. 3rd ed., China Elsevier Ltd; 2013.
  • 4. Pogrel MA. Benign Nonodontogenic Lesions of the Jaws. In: Ghali GE, editor. Peterson’s Principles of Oral and Maxillofacial Surgery. 2nd ed. London, BC Decker Inc; 2004. 603-604.
  • 5. Harorlı A. Ağız, Diş ve Çene Radyolojisi. 1st ed. İstanbul: Nobel Tıp Kitapevleri; 2014.
  • 6. Stuart C. White MJP. Oral Radiology Principles and Interpretation. 7th ed. St. Louis, Missouri; 2014.
  • 7. Sass SMG, Pinto MC. Giant cell reparative granuloma in the mandible. Braz J Otorhinolaryngol 2010;76(2):273
  • 8. Gökler A, Türkoğlu G, Taşkoparan G. Santral dev hücreli granüloma (central giant cell granuloma). K.B.B. ve Baş Boyun Cerrahisi Dergisi. 1994;2(1).
  • 9. Daroit NB, de Marco RG, Sant’Anna Filho M, Fritscher GG. The challenge in the treatment of central giant cell granuloma – What is the best approach? J Oral Maxillofac Surg Med Pathol. 2017;29(2):122-128.
  • 10. Jaffe HL. Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol 1953;6:159-75.
  • 11. Allon DM, Anavi Y, Calderon S. Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107: 811-8.
  • 12. Yamaguchi T, Dorfman HD. Giant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 2001;9:189-200.
  • 13. Tosco P, Tanteri G, Iaquinta C, et al. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: a review of 18 cases. J Craniomaxillofac Surg 2009;37:380-7.
  • 14. Cohen MA, Hertzanu Y. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol 1988; 65:255-61.
  • 15. Triantafillidou K, Venetis G, Karakinaris G, Iordanidis F. Central Giant Cell Granuloma of the Jaws: A Clinical Study of 17 Cases and a Review of the Literature. Ann Otol Rhinol Laryngol. 2011;120(3):167-174.
  • 16. Ruggieri M, Pavone V, Polizzi A, et al. Unusual form of recurrent giant cell granuloma of the mandible and lower extremities in a patient with neurofibromatosis type 1.
  • 17. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:67-72.
  • 18. A, Türkoğlu G, Taşkoparan G. Santral dev hücreli granüloma. K.B.B. ve Baş Boyun Cerrahisi Dergisi. 1994;2(1).
  • 19. Vasconcelos RG, Vasconcelos MG, Queiroz LMG. Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment. J Bras Patol Med Lab 2013;49:446–52.
  • 20. Rather V, Dorfman HD. Giant cell reparative granuloma of the hand and foot bones. Clin Orthop 1990: 260: 251–8
  • 21. Shafer WG, Hine MK, Levy BM, eds.: A textbook of oral pathology. New York: Saunders, 1983: 146–9.
  • 22. Rosenberg AJWP, Bosschaart AN, Jacops JWG, Wirds JJ, Koole R. Calcitoninetherapie bij grote of recidiverende centrale reuzencelgranulomen van de onderkaak. Ned Tijdschr Geneeskd 1997: 141: 335–9.
  • 23. Van Damme PA, Mooren RECM. Differentiation of multiple giant cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism. Int J Oral Maxillofac Surg 1994: 23: 32–6.
  • 24. Harris M: Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 31:89, 1993.
  • 25. Kermer C, Millesi W, Watzke IM: Local injection of corticosteroids for central giant cell granuloma: A case report. Int J Oral Maxillofac Surg. 23:366, 1994
There are 25 citations in total.

Details

Primary Language English
Subjects Facial Plastic Surgery
Journal Section Case Reports
Authors

Halil İbrahim Durmuş 0000-0003-4762-4788

Cansu Geben 0009-0006-2829-8920

Publication Date August 30, 2024
Submission Date August 16, 2024
Acceptance Date August 28, 2024
Published in Issue Year 2024 Volume: 4 Issue: 2

Cite

APA Durmuş, H. İ., & Geben, C. (2024). Central Giant Cell Granüloma : 3 Cases Report. HRU International Journal of Dentistry and Oral Research, 4(2), 69-73. https://doi.org/10.61139/ijdor.1534452
AMA Durmuş Hİ, Geben C. Central Giant Cell Granüloma : 3 Cases Report. HRU Int J Dent Oral Res. August 2024;4(2):69-73. doi:10.61139/ijdor.1534452
Chicago Durmuş, Halil İbrahim, and Cansu Geben. “Central Giant Cell Granüloma : 3 Cases Report”. HRU International Journal of Dentistry and Oral Research 4, no. 2 (August 2024): 69-73. https://doi.org/10.61139/ijdor.1534452.
EndNote Durmuş Hİ, Geben C (August 1, 2024) Central Giant Cell Granüloma : 3 Cases Report. HRU International Journal of Dentistry and Oral Research 4 2 69–73.
IEEE H. İ. Durmuş and C. Geben, “Central Giant Cell Granüloma : 3 Cases Report”, HRU Int J Dent Oral Res, vol. 4, no. 2, pp. 69–73, 2024, doi: 10.61139/ijdor.1534452.
ISNAD Durmuş, Halil İbrahim - Geben, Cansu. “Central Giant Cell Granüloma : 3 Cases Report”. HRU International Journal of Dentistry and Oral Research 4/2 (August 2024), 69-73. https://doi.org/10.61139/ijdor.1534452.
JAMA Durmuş Hİ, Geben C. Central Giant Cell Granüloma : 3 Cases Report. HRU Int J Dent Oral Res. 2024;4:69–73.
MLA Durmuş, Halil İbrahim and Cansu Geben. “Central Giant Cell Granüloma : 3 Cases Report”. HRU International Journal of Dentistry and Oral Research, vol. 4, no. 2, 2024, pp. 69-73, doi:10.61139/ijdor.1534452.
Vancouver Durmuş Hİ, Geben C. Central Giant Cell Granüloma : 3 Cases Report. HRU Int J Dent Oral Res. 2024;4(2):69-73.