INVESTIGATION OF THE EFFECT OF EXERCISE ON IRISIN HORMONE IN EXPERIMENTALLY INDUCED DIABETIC RATS

Year 2017, , 51 - 57, 22.12.2017

Hazal Küçükkaraca , Mehtap Ünlü Söğüt

https://doi.org/10.23884/ijhsrp.2017.2.2.03

Cited By: 2

Abstract

Investigating the
possible effects of the irisin hormone, which has been discovered in recent
years, on energy expenditure and glucose metabolism has been found to have
positive effects on end-stage diseases. The irisin secreted by the skeletal
muscle in mice and humans; is a hormone thought to improve energy consumption
and improve systemic metabolism by making white fat tissue turn into brown fat
tissue. Thanks to the knowledge that the structure of the irisin hormone is
100% similar in rats and humans, researches on experimental animals may be
helpful for human studies. It has been suggested that irisin, which has been
studied in particular for its positive effects on obesity and diabetes, may be
a promising alternative treatment for metabolic diseases. In our study that we
have planned, we aimed to determine the changes that exercise will bring about
at the level of irisin hormone in diabetic animal models that will be created
experimentally and to evaluate the effects of these changes on diabetes,
insulin resistance, lipid profile, obesity and inflammation from Metabolic
Syndrome components. For this purpose, we have 3 groups; control group,
diabetic and diabetic exercise group. The effects of exercise on the level of
irisin hormone were investigated in the obtained serum samples. In order to
observe the obesity process, the rats in each group were weighed weekly and
their body weights were measured. When the weights of the groups at the
beginning and 4 weeks were observed, a mean increase of 35.8 g (p <0.05) was
observed in the control group, 30 g (p <0.05) in the diabetic group and 59 g
in the diabetic exercise group (p> 0.05). The mean fasting blood glucose
value of the diabetic group was 477.17 ± 87.98 mg / dl and the diabetic
exercise group had a mean of 485 ± 86.03 mg / dl. When the irisin levels were
examined, it was seen that there was a difference between the groups (p> 0.05).
In the  control group, average irisin
level was 255.73 ± 374.81 ng/ml, in the diabetic group was
98.09 ± 51.25 ng/ml and in the diabetic
exercise group was  of 66.43 ± 25.01 ng/ml. As a result, injectable irisin forms are produced because of
irisin hormone is an important alternative in the treatment of obesity and
diabetes as well as other metabolic diseases; it can be thought that the
frequency can be used to control diabetes and obesity which are increasing day
by day.

Keywords

irisin, diabetes, exercise, obesity

References

• Yrd. Doç. Dr. Rojan GÜMÜŞ