EXPERIMENTAL INVESTIGATION OF THE EFFECT ON THE CHEMERIN ADIPOKINE AND OBESITY OF PROBIOTIC USE IN OBESE RATS

Year 2017, , 58 - 64, 22.12.2017

Menşure Nur Çelik , Mehtap Ünlü Söğüt

https://doi.org/10.23884/ijhsrp.2017.2.2.04

Cited By: 1

Abstract

Chemerin is a new
chemotactic protein that recently joined the adipokines family. It has been
shown to play a role in adipogenesis and energy metabolism, including its role
on obesity, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome and
cardiovascular diseases. Probiotics may play role in the prevention of obesity
by various mechanisms and treatment of many diseases such as T2DM. In this
study, we aimed to evaluate the effects of probiotic supplementation of
chemerin adipokines on serum levels and obesity markers in obese animal models.
For this purpose 3 groups of experimental animals were formed. In the obtained
serum samples, the effects of probiotic supplementation on chemerin and leptin
level which are indicators of obesity will be examined. Weights of all the rats
in the groups were weighed each week to monitor the obesity. The weight gain in
the group fed with probiotic supplementation was 10,00±27,2 g for 4 weeks and
the weight gain for the group fed with high fat diet was 26,200±7,085 g
(p<0.05). After 8 weeks of feding the changes of BMI values of the rats were
found to be statistically significant (p<0.05). There was no significant
difference between the leptin values of the groups, but the difference between
the mean values of the chemerin values after 12 weeks of feeding was found to
be statistically significant (p <0.05). As a result; this study showed that
obese rats reduced the weight gain of probiotic supplementation without calorie
restriction, positive effects on BMI and chemerin adipokine serum levels. 

Keywords

chemerin, leptin, obesity

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