EVALUATION OF THE OF INSULIN RESISTANCE EFFECTS ON OBESITY AND RELATED PARAMETERS

Year 2018, , 46 - 52, 01.08.2018

Aybike Gizem Kayacan , Mehtap Unlu Sogut , Neslihan Sürmeli Elanur Yılmaz

https://doi.org/10.23884/ijhsrp.2018.3.2.01

Abstract

Obesity,
especially abdominal obesity,  is one of
the most important underlying risk factors for metabolic syndrome and increases
the risk of developing various pathological conditions like Type 2 Diabetes
Mellitus, dyslipidemia, hypertension and Non Alcoholic Fatty Liver Disease.
Insulin resistance means that the ability of insulin to stimulate glucose
utilization is reduced, it is an integral feature of the metabolic syndrome and
an important predictor of Type 2 Diabetes Mellitus development. It is well known that obesity is associated with diabetes mellitus, and
the main basis of this link is thought to be the ability of obesity to
stimulate insulin resistance. In this
study, we aimed to evaluate the relationship between insulin resistance and
obesity, related biochemical parameters, body analysis data. In this retrospective case control study,
the insulin resistance status of 120 volunteers in Samsun Buyuk Anadolu
Hospital's Nutrition and Diet Policlinic was determined by calculating the
Homeostatic Model Assessment-Insulin Resistance formula. Biochemical values and
body analysis results of individuals with and without insulin resistance were
compared. Insulin resistance was detected in 56 (%46,7) of the subjects
participating in the study. Insulin
resistance was significantly related with weight, body mass index, body fat
mass, abdominal fat mass (p<0,05). However, there was no correlation between
insulin resistance and body fat percentage and abdominal fat percentage (p>0,05).
Fasting plasma glucose, HbA1c percentages, insulin, triglyceride and ALT levels
were found to be higher in individuals with insulin resistance (p<0,05).
There was no significant relationship between insulin resistance and cholesterol,
AST and B12 levels (p>0,05). In conclusion, considering the risks of
diseases caused by insulin resistance, findings of this study emphasizes the
importance of detecting insulin resistance. Determining the presence of insulin
resistance can help prevent a variety of diseases by regulating nutrition. Detection of insulin resistance and
regulation of nutrition can help prevent various diseases.

Keywords

insulin resistance, obesity

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