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CORRELATION OF GATA-3, E-CADHERIN, P53 AND KI-67 EXPRESSION WITH HISTOLOGICAL TYPE/MOLECULAR SUBTYPE AND CLINICOPATHOLOGICAL PARAMETERS IN BREAST CANCER

Year 2021, , 105 - 116, 28.04.2021
https://doi.org/10.33457/ijhsrp.875887

Abstract

Aims
The purpose of our study is to examine immunohistochemically the correlation of GATA binding protein 3 (GATA3), E-cadherin, p53 and Ki-67 expression with histological type/molecular subtype and clinicopathological parameters in breast cancer.
Methods and results
120 patients diagnosed with breast cancer were retrospectively investigated between 2018 May and 2021 January. We used the GATA3, E-cadherin, P53, Ki67 antibody by immunohistochemical analysis in breast tumors. GATA3 was positive in 100% (107/107) of the luminal A, luminal B and HER2 overexpressing groups and 79.9% (10/13) of the triple negative (TN) group. It is less common in the TN group (p <0.005). Ki67 of >20% was higher in human epidermal growth factor receptor 2 (HER2) overexpressing and TN groups compared to luminal A and luminal B subtypes (p <0.05). Estrogen receptor (ER) and progesterone receptor (PR) were more frequently observed in the group with Ki67≥20% than that with Ki67 <20% (71/120, 59.2%) (p = 0.024). ER/PR hormone receptors were observed more in the p53-negative group than in the p53-positive group (66/117, 56.4%) (p=0.037). There is no significant difference between molecular subtypes in terms of the incidence of e-cadherin and p53 immunoexpressions (p> 0.05).
Conclusions
Our study demonstrated that the presence of GATA3 was found to be associated with the ER/PR receptor and tumors associated with these receptors, lumen type breast carcinomas. In addition to its proper use for diagnostic purposes in routine surgical pathology, GATA3 will have a developmental role in breast carcinomas and prognostic significance in different molecular subtypes of tumors at the same clinical stage. Ki67 is observed at a higher rate in high-grade tumors and has a prognostic significance. No significant correlation was reported between e-cadherin and p53 and prognostic factors.

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References

  • 1. Al-Thoubaity FK. Molecular classification of breast cancer: A retrospective cohort study. Ann Med Surg (Lond). 2019 Dec 6;49:44-48. doi: 10.1016/j.amsu.2019.11.021. 2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum in: CA Cancer J Clin. 2020 Jul;70(4):313.
Year 2021, , 105 - 116, 28.04.2021
https://doi.org/10.33457/ijhsrp.875887

Abstract

Supporting Institution

yok

Project Number

yok

Thanks

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References

  • 1. Al-Thoubaity FK. Molecular classification of breast cancer: A retrospective cohort study. Ann Med Surg (Lond). 2019 Dec 6;49:44-48. doi: 10.1016/j.amsu.2019.11.021. 2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12. Erratum in: CA Cancer J Clin. 2020 Jul;70(4):313.
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Details

Primary Language English
Subjects Clinical Sciences
Journal Section Article
Authors

Yeliz Arman Karakaya 0000-0002-6669-9972

Sevda Yılmaz 0000-0002-1309-0805

Project Number yok
Publication Date April 28, 2021
Submission Date February 7, 2021
Acceptance Date April 26, 2021
Published in Issue Year 2021

Cite

IEEE Y. Arman Karakaya and S. Yılmaz, “CORRELATION OF GATA-3, E-CADHERIN, P53 AND KI-67 EXPRESSION WITH HISTOLOGICAL TYPE/MOLECULAR SUBTYPE AND CLINICOPATHOLOGICAL PARAMETERS IN BREAST CANCER”, IJHSRP, vol. 6, no. 1, pp. 105–116, 2021, doi: 10.33457/ijhsrp.875887.

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