PROGNOSTIC VALUE OF DYNAMIC THIOL-DISULFIDE HOMEOSTASIS IN PREDICTING HOSPITAL MORTALITY IN HYPOXEMIC RESPIRATORY FAILURE

Abstract

Hypoxemic respiratory failure (HRF) has a PaO2 < 60 mmHg with normal or subnormal PaCO2. The gas exchange is impaired at the level of the alveolo-capillary membrane. HRF is associated with high mortality in hospital, and there is no diagnostic laboratory test to predict this mortality. This study evaluates the possibility of predicting mortality in HRF patients with dynamic thiol-disulfide homeostasis parameters, which are indicators of oxidation state. Sixty-two patients with HRF and 40 healthy controls were included in the study. Dynamic thiol-disulfide parameters were studied from the serum of all participants. Total and native thiol levels were significantly lower in the patients than in the controls (p < 0.05). Disulfide levels were higher in patients who died than survivors (p <0.01). The logistic regression analysis determined that the rise in disulfide values increased the mortality risk 1.57 times. Progressive hypoxemia increases oxidation. Serum disulfide level is a valuable parameter in predicting mortality in hypoxemia.

Keywords

• Hypoxemia
• thiol-disulfid
• , thiol-disulfid
• oxidative stress
• mortality

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