Yıl 2019, Cilt 4 , Sayı 2, Sayfalar 124 - 130 2019-08-27

HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES

Yusuf NERGİZ [1] , Engin DEVECİ [2] , Muhammet Erdal SAK [3] , Mehmet Sıddık EVSEN [4] , Cenap EKİNCİ [5] , Sebnem NERGİZ [6] , Beyza KARADEDE UNAL [7] , Ugur SEKER [8]


Aim: This study aimed to histological changes compare placental villous basal lamina and amniotic membrane changes in complicated pregnancy.

Methods: Studies were performed on the human placentas, delivered between 24-39 weeks of gestation. Patients were separated equally into 4 groups (Control, preeclampsia (PE), gestastional diabetes (GD), and HELLP syndrome groups)

 Placental tissue samples were dissected and fixed in 10% neutral formalin buffer. Routine paraffin tissue protocol was followed. Some of sections were stained with Periodic Acid Schiff. Remaining sections were stained with integrin alpha-6 antibody.To define expression percentage, mean of the staining area/total staining area ratio were calculated. The statistical significance of the expression percentages was compared by One Way ANOVA and Tukey tests with SPSS Statistics V24 software.

Results: In PAS-stained preeclamptic, HELLP and gestational diabetes groups placental villous basal lamina and vasculo-syncytial membranes were thicker than the control group. A significant difference was observed in all 3 groups compared to the control group the placental villous basal lamina thickness of the HELLP group was found to be significantly different from all three groups. In chorionic villi of HELLP group, dense integrin expression was found in placental villous basal lamina similar to that in GD and preeclampsia groups. The HELLP group was significantly different from all groups.

Conclusion: In preeclampsia, gestational diabetes and HELLP placentas, placental viiöz basal lamina and amniotic membrane significantly thickened and structural changes were observed.

Placenta, Basal lamina, Preeclampsia, Gestational diabetes, HELLP syndrome
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Birincil Dil en
Konular Gelişim Biyolojisi
Bölüm Article
Yazarlar

Orcid: 0000-0002-9988-9385
Yazar: Yusuf NERGİZ (Sorumlu Yazar)
Kurum: FACULTY OF MEDICINE
Ülke: Turkey


Yazar: Engin DEVECİ
Kurum: FACULTY OF MEDICINE

Yazar: Muhammet Erdal SAK
Kurum: FACULTY OF MEDICINE

Yazar: Mehmet Sıddık EVSEN
Kurum: FACULTY OF MEDICINE

Yazar: Cenap EKİNCİ
Kurum: FACULTY OF MEDICINE

Yazar: Sebnem NERGİZ
Kurum: DICLE UNIVERSITY, ATATURK HEALTH VOCATIONAL SCHOOL

Yazar: Beyza KARADEDE UNAL
Kurum: IZMIR KATIP CELEBI UNIVERSITY, FACULTY OF DENTISTRY

Orcid: 0000-0002-1693-6378
Yazar: Ugur SEKER
Kurum: FACULTY OF MEDICINE

Destekleyen Kurum Dicle University
Proje Numarası 13-TF-158
Tarihler

Başvuru Tarihi : 3 Temmuz 2019
Kabul Tarihi : 22 Temmuz 2019
Yayımlanma Tarihi : 27 Ağustos 2019

Bibtex @araştırma makalesi { ijhsrp586011, journal = {International Journal of Health Services Research and Policy}, issn = {}, eissn = {2602-3482}, address = {Dicle Üniversitesi Teknokenti Silvan Bulvarı 222/3 21280 SUR/DİYARBAKIR}, publisher = {Rojan GÜMÜŞ}, year = {2019}, volume = {4}, pages = {124 - 130}, doi = {10.23884/ijhsrp.2019.4.2.06}, title = {HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES}, key = {cite}, author = {Nergi̇z, Yusuf and Deveci̇, Engin and Sak, Muhammet Erdal and Evsen, Mehmet Sıddık and Eki̇nci̇, Cenap and Nergi̇z, Sebnem and Karadede Unal, Beyza and Seker, Ugur} }
APA Nergi̇z, Y , Deveci̇, E , Sak, M , Evsen, M , Eki̇nci̇, C , Nergi̇z, S , Karadede Unal, B , Seker, U . (2019). HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES . International Journal of Health Services Research and Policy , 4 (2) , 124-130 . DOI: 10.23884/ijhsrp.2019.4.2.06
MLA Nergi̇z, Y , Deveci̇, E , Sak, M , Evsen, M , Eki̇nci̇, C , Nergi̇z, S , Karadede Unal, B , Seker, U . "HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES" . International Journal of Health Services Research and Policy 4 (2019 ): 124-130 <https://dergipark.org.tr/tr/pub/ijhsrp/issue/48345/586011>
Chicago Nergi̇z, Y , Deveci̇, E , Sak, M , Evsen, M , Eki̇nci̇, C , Nergi̇z, S , Karadede Unal, B , Seker, U . "HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES". International Journal of Health Services Research and Policy 4 (2019 ): 124-130
RIS TY - JOUR T1 - HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES AU - Yusuf Nergi̇z , Engin Deveci̇ , Muhammet Erdal Sak , Mehmet Sıddık Evsen , Cenap Eki̇nci̇ , Sebnem Nergi̇z , Beyza Karadede Unal , Ugur Seker Y1 - 2019 PY - 2019 N1 - doi: 10.23884/ijhsrp.2019.4.2.06 DO - 10.23884/ijhsrp.2019.4.2.06 T2 - International Journal of Health Services Research and Policy JF - Journal JO - JOR SP - 124 EP - 130 VL - 4 IS - 2 SN - -2602-3482 M3 - doi: 10.23884/ijhsrp.2019.4.2.06 UR - https://doi.org/10.23884/ijhsrp.2019.4.2.06 Y2 - 2019 ER -
EndNote %0 International Journal of Health Services Research and Policy HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES %A Yusuf Nergi̇z , Engin Deveci̇ , Muhammet Erdal Sak , Mehmet Sıddık Evsen , Cenap Eki̇nci̇ , Sebnem Nergi̇z , Beyza Karadede Unal , Ugur Seker %T HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES %D 2019 %J International Journal of Health Services Research and Policy %P -2602-3482 %V 4 %N 2 %R doi: 10.23884/ijhsrp.2019.4.2.06 %U 10.23884/ijhsrp.2019.4.2.06
ISNAD Nergi̇z, Yusuf , Deveci̇, Engin , Sak, Muhammet Erdal , Evsen, Mehmet Sıddık , Eki̇nci̇, Cenap , Nergi̇z, Sebnem , Karadede Unal, Beyza , Seker, Ugur . "HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES". International Journal of Health Services Research and Policy 4 / 2 (Ağustos 2019): 124-130 . https://doi.org/10.23884/ijhsrp.2019.4.2.06
AMA Nergi̇z Y , Deveci̇ E , Sak M , Evsen M , Eki̇nci̇ C , Nergi̇z S , Karadede Unal B , Seker U . HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES. IJHSRP. 2019; 4(2): 124-130.
Vancouver Nergi̇z Y , Deveci̇ E , Sak M , Evsen M , Eki̇nci̇ C , Nergi̇z S , Karadede Unal B , Seker U . HISTOLOGICAL OF CHANGES IN THE AMNIOTIC MEMBRANE AND PLACENTAL VILLOUS BASAL LAMINA IN COMPLICATED PREGNANCIES. International Journal of Health Services Research and Policy. 2019; 4(2): 124-130.