THE ROLE OF C-REACTIVE PROTEIN AND ALBUMIN COMBINED INDEXES IN ACUTE CHOLECYSTITIS

Yıl 2022, Cilt: 7 Sayı: 3, 309 - 315, 25.12.2022

Hatice Şeyma Akça , Ercan Gürlevik , Muhammed Tahir Akça , Hilal Akça

https://doi.org/10.33457/ijhsrp.1185159

Cited By: 2

Öz

Aim
This study aimed to determine and compare the abilities of the CAR, GPS, and mGPS to predict short-term mortality in patients with acute cholecystitis.
Materials and Methods
This retrospective study used the examinations and data of patients who attended the Emergency Department were used. The Statistical Package for Social Sciences (SPSS) software (v.20; Chicago, IL, USA) was used for all statistical analyses. All results with p < 0.05 were considered statistically significant.
Results
This study included 269 patients aged 58.3±17.4 years, of which 51% were women. The abilities of CAR, GPS, and mGPS to predict mortality were found to be statistically significant. Their AUC values were 0.73 (0.09–0.98) for CAR with a cut-off value of 3.9 (p = 0.003), 0.72 (0.10–0.97) for GPS with a cut-off value of 2 (p = 0.006), and 0.73 (0.10–0.97) for mGPS with a cut-off value of 2.
Conclusions
Inflammatory markers, including CRP and albumin, can predict the prognosis of patients with acute cholecystitis, as in many other diseases.

Anahtar Kelimeler

CRP, Albumin, CAR, GPS, mGPS

Kaynakça

• Yokoe, M., Hata, J., Takada, T., et al. "Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) ", J Hepatobiliary Pancreat Sci, 25(1), 41-54, 2018. https://doi.org/10.1002/jhbp.515.
• Yeşiltaş, M., Karakaş, D.Ö., Arıbal, S., et al. "Percutaneous cholecystostomy results of 136 acute cholecystitis patients: A retrospective cohort study", J Surg Med, 5(9), 894-9, 2021. https://doi.org/10.28982/josam.980122.
• Rajab, I.M., Majerczyk, D., Olson, M.E., et al. "C-reactive protein in gallbladder diseases: diagnostic and therapeutic insights", Biophys Rep, 6(2-3), 49-67, 2020. https://doi.org/10.1007/s41048-020-00108-9.
• Wang, Y., Hu, X., Huang, Y., et al. "Prognostic value of the C-reactive protein to albumin ratio in esophageal cancer: a systematic review and meta-analysis", Kaohsiung J Med Sci, 36(1), 54-61, 2020. https://doi.org/ 10.1002/kjm2.12129.
• Kinoshita, A., Onoda, H., Imai, N., et al. "The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma", Ann Surg Oncol, 22, 803-10, 2015. https://doi.org/10.1245/s10434-014-4048-0.
• Qin, G., Tu, J., Liu, L., et al. "Serum albumin and C-reactive protein/albumin ratio are useful biomarkers of Crohn’s disease activity", Med Sci Monit, 22, 4393-400, 2016. https://doi.org/10.12659/msm.897460.
• Kim, M.H., Ahn, J.Y., Song, J.E., et al. "The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goaldirected therapy", PLoS One, 10(7), e0132109, 2015. https://doi.org/10.1371/journal.pone.0132109.
• Özdemir, S., Akça, H.Ş., Algın, A., Eroğlu, S.E., "Can C-reactive protein-to-albumin ratio be a predictor of short-term mortality in community-acquired pneumonia? ", Ann Clin Anal Med, 12(9), 1043-8, 2021. https://doi.org/10.4328/ACAM.20576.
• Özdemir, S., Algin, A., "Evaluation of the ability of the C-reactive protein-to-albumin ratio to predict short-term mortality in patients with COVID-19 ", J CLIN MED KAZ, 18(6), 35-9, 2021. https://doi.org/10.23950/jcmk/11324.
• Terazawa, K., Ohashi, T., Shibata, H., Ishihara, T., Ogawa, T., "Immune-modified Glasgow prognostic score: A new prognostic marker for head and neck cancer", Head & Neck, 1‐9, 2022. https://doi.org/10.1002/hed.27170.
• Xu, S., Song, L., Liu, X., "Prognostic Value of Pretreatment Glasgow Prognostic Score/Modified Glasgow Prognostic Score in Ovarian Cancer: A Systematic Review and Meta-Analysis", Nutrition and Cancer, 74, 6, 1968-75, 2022. https://doi.org/10.1080/01635581.2021.1980591.
• Nie, D., Zhang, L., Wang, C., Guo, Q., Mao, X., "A high Glasgow prognostic score (GPS) or modified Glasgow Nutrition and Cancer prognostic score (mGPS) predicts poor prognosis in gynecologic cancers: a systematic review and meta-analysis", Arch Gynecol Obstet, 301(6), 1543–51, 2020. https://doi.org/10.1007/s00404-020-05581-8.
• Karakaş, D.O., Yeşiltaş, M., "Validity of the Glasgow prognostic score and modified systemic inflamma-tion score in predicting complicated cholecystitis", Hippokratia, 24(1), 15-20, 2020.
• Cakcak, İ.E., Kula, O., "Predictive evaluation of SIRI, SII, PNI, and GPS in cholecystostomy application in patients with acute cholecystitis", Turkish Journal of trauma and emergency surgery, 28, 940-6, 2022. https://doi.org/10.14744/tjtes.2022.90249.
• Sato, N., Kinoshita, A., Imai, N., et al. "Inflammation-based prognostic scores predict disease severity in patients with acute cholecystitis", Eur J Gastroenterol Hepatol, 30(4), 484-9, 2018. https://doi.org/10.1097/MEG.0000000000001063.