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Investigating the Antibacterial Effects of Zataria multiflora Methanolic Extract on Standard Pathogenic Bacteria in Laboratory Conditions

Yıl 2024, Cilt: 8 Sayı: 2, 102 - 110

Öz

Alternative treatments are becoming more and more necessary due to the increasing growth in medication resistance to synthetic antibiotics. The purpose of this study was to examine the antibacterial capabilities of an extract from Zataria multiflora (Z. multiflora) against a variety of pathogenic bacteria. Z. multiflora plants were collected from the natural resources of Isfahan province and verified as Z. multiflora by botanists from the Agricultural Jihad Organization. Methanolic extract of Z. multiflora was prepared, and its effects were tested at concentrations of 50 mg/ml, 100 mg/ml, 200 mg/ml, and 400 mg/ml using the well diffusion and disk diffusion methods on Staphylococcus aureus (S. aureus), Bacillus cereus (B. cereus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa). Minimum inhibitory concentration of bacterial growth and minimum bacterial pathogen concentration (MIC/MBC) were determined through dilution in tubes. The outcomes showed that both gram-positive and gram-negative bacteria were significantly inhibited by the methanolic extract of Z. multiflora. The MBC/MIC analysis revealed that S. aureus was the most sensitive, while E. coli was the least sensitive to the Z. multiflora extract. The study shows the potential of the methanolic extract from Z. multiflora against various pathogenic bacteria, including Gram-positive and Gram-negative ones. It suggests it could be a viable alternative to synthetic antibiotics, especially in the face of antibiotic resistance. Further research is needed to understand its mechanisms, optimize extract preparation, and explore its clinical applications..

Kaynakça

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  • Alizadeh, H., Jafari, B., & Babai, T. (2012). The study of antibacterial effect of Capsella bursapastoris on some of gram positive and gram negative bacteria. Journal of Basic and Applied Scientific Research, 2 (7), 6940-6945.
  • Andacheh, F., Moslehishad, M., Shojaee-Aliabadi, S., & Jannatyha, N. (2020). Production and characterization of antimicrobial carboxymethyl cellulose (cmc) films containing essentiol oils of Satureja khuzistanica, Zataria multiflora, Allium sativum and Bunium persicum. Journal of Medicinal plants and By-Products, 9 (Special), 35-45. htpp://doi.org/10.22092/jmpb.2020.121749
  • Atapour, M., Zahedi, M. J., Mehrabani, M., Safavi, M., Keyvanfard, V., Foroughi, A., Siavoshi, F., & Foroumadi, A. (2009). In vitro susceptibility of the gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharmaceutical Biology, 47 (1), 77-80. htpp://doi.org/10.1080/13880200802434401
  • Azizkhani, M., Misaghi, A., Akhondzadeh Basti, A., Gandomi Nasrabadi, H., & Hosseini, H. (2012). Effect of Zataria multiflora Boiss. essential oil on growth and enterotoxin e production of Staphylocuccus aureus ATCC 29213. Journal of Medicinal Plants, 11 (44), 185-192.
  • Cockerill, F. R. (2013). Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Third Informational Supplement. Wayne, Pennsylvania: Clinical and Laboratory Standards Institute.
  • Cowan, M. M. (1999). Plant Products as antimicrobial agents. Clinical Microbiology Reviews, 12 (4), 564-582.
  • Dadashi, M., Hashemi, A., Eslami, G., Fallah, F., Goudarzi, H., Erfanimanesh, S., & Taherpour, A. (2016). Evaluation of antibacterial effects of Zataria multiflora Boiss. extracts against ESBL-producing Klebsiella pneumoniae strains. Avicenna Journal of Phytomedicine, 6 (3), 336-343.
  • Davazdahemami, A., & Behbahani, M. (2022). Investigating in silico and in vitro anti-bacterial activity of eight monofloral iranian honey types. Research in Molecular Medicine, 10(2), 133-142. https://doi.org/10.32598/rmm.10.2.1195
  • Deans, S. G., Simpson, E., Noble, R. C., MacPherson, A., & Penzes, L. (1993). Natural antioxidants from Thymus vulgaris (Thyme) volatile oil: the beneficial effects upon mammalian lipid metabolism. Acta Horticulturae, 342, 237-241.
  • Fallah, F., Taherpour, A., Borhan, R. S., Hashemi, A., Habibi, M., & Sajadi Nia, R. (2013). Evaluation of Zataria multiflora Boiss. and Carum copticum antibacterial activity on IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa. Annals of Burns and Fire Disasters, 26 (4), 193-198.
  • Fazeli, M. R., Amin, G., Attari, M. M. A., Ashtiani, H., Jamalifar, H., & Samadi, N. (2007). Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control, 18 (6), 646-649. https://doi.org/10.1016/j.foodcont.2006.03.002
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  • Golkar, P., Mosavat, N., & Jalali, S. A. H. (2020). Essential oils, chemical constituents, antioxidant, antibacterial and in vitro cytotoxic activity of different Thymus species and Zataria multiflora collected from Iran. South African Journal of Botany, 130, 250-258. https://doi.org/10.1016/j.sajb.2019.12.005
  • Goudarzi, M., Sattari, M., Najar Piraieh, S., Goudarzi, G., & Bigdeli, M. (2006). Antibacterial effects of aqueous and alcoholic extracts of Thyme on enterohemorrhagic Escherichia coli. Yafteh, 8 (3), 63-69.
  • Hatami Pirghibi, T., Chehri, K., Abiri, R., & Karimi, I. (2021). Effect of hydro-alcoholic extracts of Rosmarinus officinalis L., Mentha piperita L., and Zataria multiflora Boiss. on biofilm formation of Pseudomonas. Research in Medicine, 45 (3), 11-17.
  • Hornok, L. (1988). Effect of environmental factors on the production of some essential oil plants. Developments in Food Science, 18, 129-140.
  • Izadiyan, P., Salehi, A., Moaddeli, A., Zarenezhad, M., & Izadiyan, M. (2022). How quantity of bioactive compounds of Zataria multiflora differ using traditional or modern extraction methods. Journal of Medicinal plants and By-Products, 11 (Special), 107-115. https://doi.org/10.22092/jmpb.2021.353668.1339
  • Jafari-Sales, A., & Hossein-Nezhad, P. (2020). Antimicrobial effects of Rosmarinus officinalis methanolic extract on Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in laboratory conditions. Journal of Medicinal and Chemical Sciences, 3 (2), 103-108. https://doi.org/10.26655/jmchemsci.2020.2.2
  • Jafarı-Sales, A., Jafari, B., Khaneshpour, H., & Pashazadeh, M. (2020). Antibacterial effect of methanolic extract of Rosa damascena on standard bacteria Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in vitro. International Journal of Nature and Life Sciences, 4 (1), 40-46.
  • Jafari-Sales, A., Jafari, B., Sayyahi, J., & Zohoori-Bonab, T. (2015). Evaluation of antibacterial activity of ethanolic extract of Malva neglecta and Althaea officinalis L. on antibiotic-resistant strains of Staphylococcus aureus. Journal of Biology and Today's World, 4 (2), 58-62. https://doi.org/10.15412/J.JBTW. 01040205
  • Jafari-Sales, A., Meshinchi, P., & Shabkhosh, A. (2021). In vitro antibacterial activity of ethanolic extract of Aloe vera and silver nanoparticles on standard strains of some pathogenic bacteria. Journal of Clinical and Basic Research, 5 (4), 22-30. https://doi.org/10.29252/Jcbr.5.4.22
  • Jafarı-Sales, A., & Pashazadeh, M. (2020). Antibacterial effect of methanolic extract of saffron petal (Crocus sativus L.) on some standard gram positive and gram negative pathogenic bacteria In vitro. Current Perspectives on Medicinal and Aromatic Plants, 3 (1), 1-7. https://doi.org/10.38093/cupmap.692879
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  • Mahmoudi, S., Nasiri, R., & Jafari Sales, A. (2019). In-vitro antibacterial effects of methanolic extract of peppermint (Mentha Piperita Lamiaceae) on standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa strain. Jorjani Biomedicine Journal, 7 (4), 4-10. https://doi.org/10.29252/jorjanibiomedj.7.4.4
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Yıl 2024, Cilt: 8 Sayı: 2, 102 - 110

Öz

Kaynakça

  • Al-Snafi, A. E., Salman Khadem, H., Al-Saedy, H. A., Alqahtani, A. M., El-Saber Batiha, G., & Jafari-Sales, A. (2021). A review on Medicago sativa: A potential medicinal plant. International Journal of Biological and Pharmaceutical Sciences Archive, 1 (2), 22-33. https://doi.org/10.30574/ijbpsa.2021.1.2.0302
  • Alizadeh, H., Jafari, B., & Babai, T. (2012). The study of antibacterial effect of Capsella bursapastoris on some of gram positive and gram negative bacteria. Journal of Basic and Applied Scientific Research, 2 (7), 6940-6945.
  • Andacheh, F., Moslehishad, M., Shojaee-Aliabadi, S., & Jannatyha, N. (2020). Production and characterization of antimicrobial carboxymethyl cellulose (cmc) films containing essentiol oils of Satureja khuzistanica, Zataria multiflora, Allium sativum and Bunium persicum. Journal of Medicinal plants and By-Products, 9 (Special), 35-45. htpp://doi.org/10.22092/jmpb.2020.121749
  • Atapour, M., Zahedi, M. J., Mehrabani, M., Safavi, M., Keyvanfard, V., Foroughi, A., Siavoshi, F., & Foroumadi, A. (2009). In vitro susceptibility of the gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharmaceutical Biology, 47 (1), 77-80. htpp://doi.org/10.1080/13880200802434401
  • Azizkhani, M., Misaghi, A., Akhondzadeh Basti, A., Gandomi Nasrabadi, H., & Hosseini, H. (2012). Effect of Zataria multiflora Boiss. essential oil on growth and enterotoxin e production of Staphylocuccus aureus ATCC 29213. Journal of Medicinal Plants, 11 (44), 185-192.
  • Cockerill, F. R. (2013). Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Third Informational Supplement. Wayne, Pennsylvania: Clinical and Laboratory Standards Institute.
  • Cowan, M. M. (1999). Plant Products as antimicrobial agents. Clinical Microbiology Reviews, 12 (4), 564-582.
  • Dadashi, M., Hashemi, A., Eslami, G., Fallah, F., Goudarzi, H., Erfanimanesh, S., & Taherpour, A. (2016). Evaluation of antibacterial effects of Zataria multiflora Boiss. extracts against ESBL-producing Klebsiella pneumoniae strains. Avicenna Journal of Phytomedicine, 6 (3), 336-343.
  • Davazdahemami, A., & Behbahani, M. (2022). Investigating in silico and in vitro anti-bacterial activity of eight monofloral iranian honey types. Research in Molecular Medicine, 10(2), 133-142. https://doi.org/10.32598/rmm.10.2.1195
  • Deans, S. G., Simpson, E., Noble, R. C., MacPherson, A., & Penzes, L. (1993). Natural antioxidants from Thymus vulgaris (Thyme) volatile oil: the beneficial effects upon mammalian lipid metabolism. Acta Horticulturae, 342, 237-241.
  • Fallah, F., Taherpour, A., Borhan, R. S., Hashemi, A., Habibi, M., & Sajadi Nia, R. (2013). Evaluation of Zataria multiflora Boiss. and Carum copticum antibacterial activity on IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa. Annals of Burns and Fire Disasters, 26 (4), 193-198.
  • Fazeli, M. R., Amin, G., Attari, M. M. A., Ashtiani, H., Jamalifar, H., & Samadi, N. (2007). Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control, 18 (6), 646-649. https://doi.org/10.1016/j.foodcont.2006.03.002
  • Foladvand, Z., Kiani, Z., Javadian, F., Hesaraki, M., Nasiri, A., & Sepehri, Z. (1970). Evaluation of the effect of antimicrobial activity of ethanol extract of Myrtus communis, Zataria multiflora Boiss. and Allium sativum on biofilm formation by Staphylococcus aureus. Journal of Sabzevar University of Medical Sciences, 21 (6), 1019-1027.
  • Ghannadi, A., Sajjadi, S.-E., Abedi, D., Yousefi, J., & Daraei-Ardekani, R. (2004). The in vitro activity of seven Iranian plants of the Lamiaceae family against Helicobacter pylori. Nigerian Journal of Natural Products and Medicine, 8 (1), 40-42. https://doi.org/10.4314/njnpm.v8i1.11812
  • Golkar, P., Mosavat, N., & Jalali, S. A. H. (2020). Essential oils, chemical constituents, antioxidant, antibacterial and in vitro cytotoxic activity of different Thymus species and Zataria multiflora collected from Iran. South African Journal of Botany, 130, 250-258. https://doi.org/10.1016/j.sajb.2019.12.005
  • Goudarzi, M., Sattari, M., Najar Piraieh, S., Goudarzi, G., & Bigdeli, M. (2006). Antibacterial effects of aqueous and alcoholic extracts of Thyme on enterohemorrhagic Escherichia coli. Yafteh, 8 (3), 63-69.
  • Hatami Pirghibi, T., Chehri, K., Abiri, R., & Karimi, I. (2021). Effect of hydro-alcoholic extracts of Rosmarinus officinalis L., Mentha piperita L., and Zataria multiflora Boiss. on biofilm formation of Pseudomonas. Research in Medicine, 45 (3), 11-17.
  • Hornok, L. (1988). Effect of environmental factors on the production of some essential oil plants. Developments in Food Science, 18, 129-140.
  • Izadiyan, P., Salehi, A., Moaddeli, A., Zarenezhad, M., & Izadiyan, M. (2022). How quantity of bioactive compounds of Zataria multiflora differ using traditional or modern extraction methods. Journal of Medicinal plants and By-Products, 11 (Special), 107-115. https://doi.org/10.22092/jmpb.2021.353668.1339
  • Jafari-Sales, A., & Hossein-Nezhad, P. (2020). Antimicrobial effects of Rosmarinus officinalis methanolic extract on Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in laboratory conditions. Journal of Medicinal and Chemical Sciences, 3 (2), 103-108. https://doi.org/10.26655/jmchemsci.2020.2.2
  • Jafarı-Sales, A., Jafari, B., Khaneshpour, H., & Pashazadeh, M. (2020). Antibacterial effect of methanolic extract of Rosa damascena on standard bacteria Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa in vitro. International Journal of Nature and Life Sciences, 4 (1), 40-46.
  • Jafari-Sales, A., Jafari, B., Sayyahi, J., & Zohoori-Bonab, T. (2015). Evaluation of antibacterial activity of ethanolic extract of Malva neglecta and Althaea officinalis L. on antibiotic-resistant strains of Staphylococcus aureus. Journal of Biology and Today's World, 4 (2), 58-62. https://doi.org/10.15412/J.JBTW. 01040205
  • Jafari-Sales, A., Meshinchi, P., & Shabkhosh, A. (2021). In vitro antibacterial activity of ethanolic extract of Aloe vera and silver nanoparticles on standard strains of some pathogenic bacteria. Journal of Clinical and Basic Research, 5 (4), 22-30. https://doi.org/10.29252/Jcbr.5.4.22
  • Jafarı-Sales, A., & Pashazadeh, M. (2020). Antibacterial effect of methanolic extract of saffron petal (Crocus sativus L.) on some standard gram positive and gram negative pathogenic bacteria In vitro. Current Perspectives on Medicinal and Aromatic Plants, 3 (1), 1-7. https://doi.org/10.38093/cupmap.692879
  • Jafari, B., Jafari-Sales, A., Khaneshpour‬‏, H., Fatemi, S., Pashazadeh, M., Al-Snafi, A. E., & Shariat, A. (2020). Antibacterial effects of Thymus vulgaris, Mentha pulegium, Crocus sativus and Salvia officinalis on pathogenic bacteria: A brief review study based on gram-positive and gram-negative bacteria. Jorjani Biomedicine Journal, 8 (3), 58-74. https://doi.org/10.29252/jorjanibiomedj.8.3.58
  • Jafari Sales, A., & Shariat, A. (2020). Synergistic Effects of silver nanoparticles with ethanolic extract of Eucalyptus globules on standard pathogenic bacteria in vitro. Tabari Biomedical Student Research Journal, 2 (3), 13-21. https://doi.org/10.18502/tbsrj.v2i3.4528
  • Jebelli Javan, A. (2016). Combinational effects of Trachyspermum ammi and Zataria multiflora Boiss. essential oils on some pathogenic food-borne bacteria. Koomesh, 17 (2), 374-383.
  • Karbasizade, V., Dehghan, P., Sichani, M. M., Shahanipoor, K., Jafari, R., & Yousefian, R. (2017). Evaluation of three plant extracts against biofilm formation and expression of quorum sensing regulated virulence factors in Pseudomonas aeruginosa. Pakistan Journal of Pharmaceutical Sciences, 30, 2 (Suppl.), 585-589.
  • Mahmoudi, S., Nasiri, R., & Jafari Sales, A. (2019). In-vitro antibacterial effects of methanolic extract of peppermint (Mentha Piperita Lamiaceae) on standard Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa strain. Jorjani Biomedicine Journal, 7 (4), 4-10. https://doi.org/10.29252/jorjanibiomedj.7.4.4
  • Meskini, M., Khaledi, A., & Esmaeili, D. (2019). Inhibitory Effects of a Herbal Ointment against Pseudomonas aeruginosa. Medical Laboratory Journal, 13 (1), 1-5. https://doi.org/10.29252/mlj.13.1.1
  • Mobaiyen, H., Jafari Sales, A., & Sayyahi, J. (2015). Evaluating antimicrobial effects of Centaurea plant’s essential oil on pathogenic bacteria: Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli Isolated from clinical specimens. Journal of Advanced Biomedical Sciences, 5 (4), 479-487.
  • Mosadegh, M., & Naghibi, F. (2002). Iran Traditional Medicine: Past & Present. Traditional Medicine and Materia Medica Research Center, 1, 2-20.
  • Motevasel, M., Okhovat, M. A., Zomorodian, K., & Farshad, S. (2014). Antibacterial effect of Zataria multiflora extract on MRSA. Iranian South Medical Journal, 17 (5), 900-906.
  • Neef, H., Declercq, P., & Laekeman, G. (1995). Hypoglycaemic activity of selected European plants. Phytotherapy Research, 9 (1), 45-48. https://doi.org/10.1002/ptr.2650090111
  • Ojagh, M., Mohammadi, N., Babakhani Lashkan, A., & Mohammadi, E. (2016). Evaluation of antibacterial activity of aqueous and ethanolic extracts of Dorema aucheri, Zataria multiflora Boiss. and Ferulago angulata against certain pathogenic microbes. Journal of Medicinal Plants Biotechnology, 2 (4), 1-9.
  • Omidpanah, S., Vazirian, M., Hadjikhondi, A., Nabavi, S., & Manayi, A. (2016). Evaluation of antibacterial activity of some medicinal plants against isolated Escherichia coli from diseased laying hens. Progress in Nutrition, 18 (4), 429-435.
  • World Health Organization. (1978). The Promotion and Development of Traditional Medicine: Report af A WHO Meeting (Held in Geneva from 28 November to 2 December 1977). In, Geneva, Switzerland: World Health Organization.
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  • Owlia, P., Saderi, H., Matloob, F., & Rezaee, M. B. (2006). Antimicrobial effect of Zataria multiflora Boiss. extract and oxacillin against Staphylococcus aureus. Iranian Journal of Medicinal and Aromatic Plants Research, 22 (1), 22-26. https://doi.org/10.22092/ijmapr.2006.114996
  • Pirbalouti, A. G., Hamedi, B., Poor, F. M., Rahimi, E., & Nejhad, R. N. (2011). Inhibitory activity of Iranian endemic medicinal plants against Vibrio parahaemolyticus and Vibrio harveyi. Journal of Medicinal Plants Research, 5 (32), 7049-7053. https://doi.org/10.5897/JMPR11.1256
  • Pourhosseini, S. H., Ahadi, H., Aliahmadi, A., & Mirjalili, M. H. (2020). Chemical composition and antibacterial activity of the carvacrol-rich essential oils of Zataria multiflora Boiss. (Lamiaceae) from southern natural habitats of Iran. Journal of Essential Oil Bearing Plants, 23 (4), 779-787. https://doi.org/10.1080/0972060X.2020.1824688
  • Ramezanpour, S., Ardestani, F., & Asadollahzadeh, M. J. (2016). Combination effects of Zataria multiflora, Laurus nobilis and Chamaemelum nobile essences on pathogenic E. coli and determination of optimum formulation using fraction and factorial statistical method. Iranian Journal of Medical Microbiology, 10 (2), 53-62.
  • Rezvannejad, E., Nasirifar, E., Lotfi, S., & Abdolinasab, M. (2019). Study and comparison of antibacterial activities of extracts of Zataria multiflora and Teucrium polium on Penibacillus alvei. Journal of the Hellenic Veterinary Medical Society, 70 (1), 1421-1428.
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  • Skaltsa, H., Lazari, D. M., Chinou, I. B., & Loukis, A. E. (1999). Composition and antibacterial activity of the essential oils of Stachys candida and S. chrysantha from southern Greece. Planta medica, 65 (3), 255-256. https://doi.org/10.1055/s-2006-960471
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  • Yadegar, A., Sattari, M., Bigdeli, M., & Bakhtiari, F. (2010). Evaluation and comparison of antibacterial effects of alcoholic extracts of Zataria multiflora Boiss. leaves, flowers and root on methicillin-resistant Staphylococcus aureus. Journal of Medicinal Plants, 9 (33), 58-65.
  • Zare Bidaki, M., Arab, M., Khazaei, M., Afkar, E., & Zardast, M. (2015). Anti-bacterial effect of Zataria multiflora Boiss. essential oil on eight gastrointestinal pathogenic species. Quarterly of the Horizon of Medical Sciences, 21 (3), 155-161. http://doi.org/10.18869/acadpub.hms.21.3.155
Toplam 59 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Tıbbi Bakteriyoloji
Bölüm Araştırma Makalesi
Yazarlar

Niloufar Yamchlou 0009-0000-5921-1046

Kağan Tolga Cinisli 0000-0003-3909-9637

Azizeh Shadi-dizaji 0000-0002-1996-7823

Zahra Ghahremani 0009-0002-9744-3707

Aylin Golestani 0009-0008-0886-9874

Kosar Soleymanpour 0009-0002-2559-4645

Kosar Hosseini-karkaj 0009-0001-1120-9665

Abolfazl Jafarı-sales 0000-0002-5710-4076

Mehrdad Pashazadeh 0000-0001-9103-6276

Erken Görünüm Tarihi 18 Ağustos 2024
Yayımlanma Tarihi
Gönderilme Tarihi 30 Mayıs 2024
Kabul Tarihi 23 Temmuz 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 8 Sayı: 2

Kaynak Göster

APA Yamchlou, N., Cinisli, K. T., Shadi-dizaji, A., Ghahremani, Z., vd. (2024). Investigating the Antibacterial Effects of Zataria multiflora Methanolic Extract on Standard Pathogenic Bacteria in Laboratory Conditions. International Journal of Nature and Life Sciences, 8(2), 102-110.