Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts

Nguyen Thi Trang; Nguyen Ngan; Nguyen Tat Son; Tran Thi Thu Hang; Hoang Van Trung

doi:10.21448/ijsm.1779764

Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts

Abstract

Alpinia menghaiensis S.Q. Tong & Y.M. Xia, a member of the Zingiberaceae family, is often used in traditional medicine. Limited information regarding phenolics and bioactivities of this plant species is available in the literature. This study evaluates the phenolic composition, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. The results revealed that the methanol/acetone extract contained the highest levels of catechin (9.22 ± 0.27 mg/g), p-coumaric acid (1.38 ± 0.02 mg/g), quercetin (1.74 ± 0.18 mg/g), and the highest total phenolic content (86.75 ± 5.89 mg/g). It also showed the most potent capacity to scavenge free DPPH and ABTS radicals, with IC50 values of 257.83 ± 13.02 and 497.20 ± 14.18 μg/mL, respectively. The extract obtained with ethyl acetate exhibited the strongest α-amylase inhibitory activity (IC50 = 394.03 ± 13.09 μg/mL). Correlation analysis demonstrated a strong positive correlation between total phenolic content and both DPPH (r = 0.958) and ABTS (r = 0.956) scavenging activities. These findings indicate that A. menghaiensis rhizomes are a rich source of phenolic compounds with significant antioxidant and enzyme inhibitory potential, making them a promising candidate for use in functional foods or pharmaceutical applications.

Keywords

Thanks

The authors would like to thank the Industrial University of Ho Chi Minh City for supporting the research.

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Details

Primary Language

English

Subjects

Natural Products and Bioactive Compounds

Journal Section

Research Article

Authors

Nguyen Thi Trang This is me
0000-0002-9792-7202
Vietnam

Nguyen Ngan ^*
0000-0002-1512-0297
Vietnam

Nguyen Tat Son This is me
0009-0001-5922-1540
Vietnam

Tran Thi Thu Hang This is me
0009-0005-3857-2973
Vietnam

Hoang Van Trung This is me
0009-0008-5813-1253
Vietnam

Early Pub Date

July 25, 2026

Publication Date

September 2, 2026

Submission Date

September 11, 2025

Acceptance Date

April 9, 2026

Published in Issue

Year 2026 Volume: 13 Number: 3

DOI

https://doi.org/10.21448/ijsm.1779764

IZ

https://izlik.org/JA37YY77JP

Cite

RIS / Bibtex

APA

Trang, N. T., Ngan, N., Son, N. T., Hang, T. T. T., & Trung, H. V. (2026). Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. International Journal of Secondary Metabolite, 13(3), 683-691. https://doi.org/10.21448/ijsm.1779764

AMA

1.Trang NT, Ngan N, Son NT, Hang TTT, Trung HV. Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. Int. J. Sec. Metabolite. 2026;13(3):683-691. doi:10.21448/ijsm.1779764

Chicago

Trang, Nguyen Thi, Nguyen Ngan, Nguyen Tat Son, Tran Thi Thu Hang, and Hoang Van Trung. 2026. “Phenolics, Antioxidant Activity, and α-Amylase Inhibitory Effect of Alpinia Menghaiensis Rhizome Extracts”. International Journal of Secondary Metabolite 13 (3): 683-91. https://doi.org/10.21448/ijsm.1779764.

EndNote

Trang NT, Ngan N, Son NT, Hang TTT, Trung HV (September 1, 2026) Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. International Journal of Secondary Metabolite 13 3 683–691.

IEEE

[1]N. T. Trang, N. Ngan, N. T. Son, T. T. T. Hang, and H. V. Trung, “Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts”, Int. J. Sec. Metabolite, vol. 13, no. 3, pp. 683–691, Sept. 2026, doi: 10.21448/ijsm.1779764.

ISNAD

Trang, Nguyen Thi - Ngan, Nguyen - Son, Nguyen Tat - Hang, Tran Thi Thu - Trung, Hoang Van. “Phenolics, Antioxidant Activity, and α-Amylase Inhibitory Effect of Alpinia Menghaiensis Rhizome Extracts”. International Journal of Secondary Metabolite 13/3 (September 1, 2026): 683-691. https://doi.org/10.21448/ijsm.1779764.

JAMA

1.Trang NT, Ngan N, Son NT, Hang TTT, Trung HV. Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. Int. J. Sec. Metabolite. 2026;13:683–691.

MLA

Trang, Nguyen Thi, et al. “Phenolics, Antioxidant Activity, and α-Amylase Inhibitory Effect of Alpinia Menghaiensis Rhizome Extracts”. International Journal of Secondary Metabolite, vol. 13, no. 3, Sept. 2026, pp. 683-91, doi:10.21448/ijsm.1779764.

Vancouver

1.Nguyen Thi Trang, Nguyen Ngan, Nguyen Tat Son, Tran Thi Thu Hang, Hoang Van Trung. Phenolics, antioxidant activity, and α-amylase inhibitory effect of Alpinia menghaiensis rhizome extracts. Int. J. Sec. Metabolite. 2026 Sep. 1;13(3):683-91. doi:10.21448/ijsm.1779764