Derleme
BibTex RIS Kaynak Göster

Review on phytochemicals and biological activities of natural sweeteners Stevia rebaudiana Bertoni

Yıl 2022, Cilt: 9 Sayı: 4, 415 - 425, 21.12.2022
https://doi.org/10.21448/ijsm.1122618

Öz

Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes awareness is necessary to prevent diabetes by reducing sugar intake and using low-calorie alternative sweeteners instead. Stevia rebaudiana is a medicinal plant species belonging to the Compositae family. It is a sweet herb that contains diterpene glycosides, which are directly responsible for the sweet taste, but they have no caloric value. Since ancient times, there have been several reports on the use of S. rebaudiana as an alternative sweetener and extended research has been conducted on its phytochemicals and biological activities. The plant contains a good number of phytochemicals with significant biological activities, namely polyphenolic derivatives, diterpenes glycosides, alkaloids, glycosides, tannins, chlorophylls, carotenoids, etc. For industrial use, those phytochemicals could be extracted from the selected plant and used for the preparation of nutraceuticals and food additives. S. rebaudiana is a natural herb; therefore, it has fewer or minimal adverse effects on human health. The selected plant in various forms is used for the treatment of diabetes, colon cancer, obesity, cavities, and others. However, the literature review shows that the information on this plant and its uses is not systematic. The purpose of the present review is to explore the status of phytochemicals and biological activities of the selected plant for young researchers. Therefore, the updated data will help them to develop new nutraceuticals and food additives that could help in the production of pharmaceuticals to treat different ailments.

Destekleyen Kurum

N/A

Proje Numarası

N/A

Kaynakça

  • Abdulsattar, A.M., & Hossain, M.A. (2020). Antibacterial and antioxidant potential of Tetraena simplex extracts of various polarities. Toxicology Reports 7, 925–929.
  • Ahmad, U., & Ahmad, R.S. (2018). Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Complementary and Alternative Medicine, 18, 179-185.
  • Al-Habsi, A.A.S., & Hossain, M.A. (2018). Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman. Egyptian Journal of Basic Applied Sciences, 5, 157–164.
  • AL-Jabri, N.N., & Hossain, M.A. (2018). Chemical composition and antimicrobial potency of locally grown lemon essential oil against selected bacterial strains. Journal of King Saud University Sciences, 30, 14-20.
  • Al-Jadidi, H.S.K., & Hossain, M.A. (2016). Determination of the total phenols, flavonoids and antimicrobial activity of the crude extracts from locally grown neem stems. Asian Pacific Journal of Tropical Diseases, 6(5), 376-379.
  • AL-Oraimi, A.A., & Hossain, M.A. (2016). In vitro total flavonoids content and antimicrobial capacity of different organic crude extracts of Dodonaea viscosa. Journal of Biologically Active Products from Nature, 6(2), 166-172.
  • Al-Qassabi, J.S.A., Weli, A.M., & Hossain, M.A. (2018). Comparison of total phenols content and antioxidant potential of peel extracts of local and imported lemons samples. Sustainable Chemistry and Pharmacy, 8, 71–75.
  • Al-Rashdi, R.S.Y., Hossain. M.A., & Al-Touby, S.S.J. (2021). Antioxidant and antibacterial activities of leaves crude extracts of Adenium obesum grown in Oman National Botanical Garden. Advances in Biomarkar Science and Technology, 3, 8-14.
  • Al-Saeedi, A.H., Al-Ghafri, M.T.H., & Hossain, M.A. (2016). Comparative evaluation of total phenols, flavonoids content and antioxidant potential of leaves and fruit extracts of Omani Ziziphus jujuba L. Pacific Science. Review A: Natural Science and Engineering, 18, 78-83.
  • Al-Saeghi, S.S., Hossain, M.M., & Al-Touby, S.S.J. (2022). Characterization of antioxidant and antibacterial compounds from the aerial parts of Haplophyllum tuberculatum. Journal Bioresources and Bioproducts, 7, 52-62.
  • Amri, F.S., & Hossain, M.A. (2018). Comparison of total phenols, flavonoids and antioxidant potential of local and imported ripe bananas. Egyptian Journal of Basic Applied Sciences, 5, 245-251.
  • Barriocanal, L., Palacios, M., Benitez, G., Benitez, S., Jimenez, J., & Jimenez, N. (2008). Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans, a pilot study of repeated exposures in some normotensive and hypotensive individuals and in type 1and type 2 diabetics. Regulatory Toxicology and Pharmacology, 51, 37–41.
  • Bemays, E.A., & Chapman, R.F. (1994). Host plant selection by phytophagous insects. Chapman and Hall, NY. USA.
  • Beutler, J.A., Caredelline, J.H., McMahon, J.B., Shoemaker, R.H., & Boyd, M.R. (1995). Phytochemistry of medicinal plants. ed. Amason J. T., Mata R., Romeo J. T. Plenum Press, NY, USA.
  • Brandle, J.E., Starratt, A.N., & Gijzen, M. (1998). Stevia rebaudiana: Its agricultural, biological, and chemical properties. Canadian Journal of Plant Science, 78, 527–536.
  • Carneiro, J.W.P. (1930). Stevia rebaudiana (Bert.) Bertoni: produção de sementes. UEM: Maringá. 61.
  • Curi, R., Alvarez, M., & Bazotte, R.B. (1986). Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Brazilian Journal of Medical and Biological Research, 19(6),771–774.
  • Das, S., Das, A.K., & Murphy, R.A. (1992). Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. Caries Research, 26(5), 363–366.
  • Dhasarathan, P., & Theriappan, P. (2011). Evaluation of anti-diabetic activity of Strychonous potatorum in alloxan induced diabetic rats. Journal of Medical Science, 2(2), 670–674.
  • Gonsumer. (2019). National Technical Information Services. 5285 Port Royal Road, Springfield, VA 22161, pp. 152–157.
  • Genus Jan, M.C. (2002). Safety evaluation of stevia and Stevioside. Journal of Natural Product Chemistry, 27(8), 299–319.
  • Goyal, S.K., Samsher, N., & Goyal, R.K. (2010). Stevia (Stevia rebaudiana) a bio-sweetener: a review. International Journal of Food Science and. Nutrition, 61(1), 1–10.
  • Hossain, M.A., Alrashdi, Y.B.A., & Al-Touby, S.S.J. (2022). A review on essential oil analyses and biological activities of the traditionally used medicinal plant Thymus vulgaris L. International Journal of Secondary Metabolite, 9(1), 103–111.
  • Hossain, M.A., Weli, A.M., & Ahmed, S.H.I. (2019). Comparison of total phenols, flavonoids and antioxidant activity of various crude extracts of Hyoscyamus gallagheri traditionally used for the treatment of epilepsy. Clinical Phytoscience, 5, 20-29.
  • Hutapea, A.M. (1997). Digestion of stevioside (a natural sweetener) by various digestive enzymes. Journal of Clinical Biochemistry and Nutrition, 23(3), 177–186.
  • Isman, M.B. (1994). Botanical insecticides. Pesticides Outline, 5, 26-30.
  • Jan, S.A., Habib, N., & Shinwari, Z.K. (2020). The anti-diabetic activities of natural sweetener plant Stevia: an updated review. SN Applied Science, 3, 517-520.
  • Jeppesen, P.B., Gregersen, S., & Poulsen, C.R. (2000). Stevioside acts directly on pancreatic beta cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism, 49(2), 208–214.
  • Kakkar, S., & Bais, S. (2014). A review on protocatechuic acid and its pharmacological potential. ISRN Pharmacy, 9, 2014-2020.
  • Katayama, O., Sumida, T., Hayashi, H., & Mitsuhashi, H. (1976). The practical application of Stevia and research and development data, I.S.U. Company, Japan, p.747
  • Klayman, D. (1985). Qinghaosu (Artemisinin) an antimalarial from China. Science, 228, 1048-1055.
  • Kobus-Moryson, M., & Gramza-Michałowska, A. (2015). Directions on the use of stevia leaves (Stevia rebauidana) as an additive in food products. Acta Scientiarum Polonorum Technologia Alimentaria, 14(1), 5–13.
  • Lemus-Mondaca, R., Vega-Galvez, A., Zura-Bravo, L., & Ah-Hen, K. (2012). Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chemistry, 132, 1121–1132.
  • Madan, S., Ahmad, S., Singh, G.N., Kohli, K., Kumar, Y., Singh, R., & Garg, M. (2010). Stevia rebaudiana (Bert.) Bertoni – A review. Indian Journal of Natural Products Resources, 1, 267-86.
  • Maisa, S., Al-Touby, S.S.J., & Hossain, M.A. (2021). Total phenols content and antioxidant activity of different polarity crude extracts of Dodonaea viscosa. Indian Drugs. 58 (08), 79-83.
  • Mann, T.S., Agnihotri, V.K., Kumar, D., Pal, P.K., Koundal, R., Kumar, A., & Padwad, Y.S. (2014). In vitro cytotoxic activity guided essential oil composition of flowering twigs of Stevia rebaudiana. Natural Product Communications, 9(5), 715–718
  • Meireles, M.A.A., Wang, G., Hao, Z., Shima, K., & Silva, J.A.T. (2006). Stevia (Stevia rebaudiana Bertoni): futuristic view of the sweeter side of life. In: Jaime A. Teixeira da Silva ed. Floriculture, ornamental and plant biotechnology: Advances and Topical Issues IV, Edition: 1, Global Science Books 416- 425.
  • Misra, H., Soni, M., Silawat, N., Mehta, D., Mehta, B.K., & Jain, D.C. (2011). Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats. Journal of Pharmacy and Bioallied Sciences, 3(2), 242–8.
  • Phillipson, J.D., & Wright, C.W. (1991). Can ethnopharmacology contribute to the development of antimalarial agents. Journal of Ethnopharmacology, 32, 155-165.
  • Rana, N., & Bais, S. (2014). Neuroprotective effect of J. communis in Parkinson disease induced animal models, Pharmacology Department, Punjab Technical University, Punjab, India.
  • Robinson, B.L. (1930). Contribution from Gray Herbarium of Harvard University, The Gray Herbarium of Harvard University, Cambridge.
  • Saravanan, R., Vengatash B.K., & Ramachandran, V. (2012). Effect of Rebaudioside A, a diterpenoid on glucose homeostasis in STZ-induced diabetic rats. Journal of Physiology and Biochemistry, 68(3), 421–431.
  • Schoonhoven, L.M. (1982). Biological aspects of antifeedants. Entomolgia Experimentalis et Applcata, 31, 57-69.
  • Shivanna, N., Naika, M., Khanum, F., & Kaul, V.K. (2013). Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. Journal of Diabetes Complications, 27(2), 103–113.
  • Siddique, A.B., Rahman, S.M.M., Hossain, M.A., & Rashid, M.A. (2014). Phytochemical screening and comparative antimicrobial potential of different extracts of Stevia rebaudiana Bertoni leaves. Asian Pacific Journal of Tropical Diseases, 4(4), 275–280.
  • Soejarto, D.D, Kinghorn, A.D., & Farnsworth, N.R. (1982). Potencial sweetening agentsof plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. Journal of Natural Products, 45, 590–599.
  • Steven, D., & Ehrlich, N.M.D. (2009). Solutions acupuncture, a private practice specializing in complementary and alternative medicine. Healthcare Network, Phoenix, Ariz, USA.
  • Tandon, V., Kapoor, K., & & Gupta, B.M. (2004). Herbal drug research in India: a trend analysis using IJP as a marker. Indian Journal of Pharmacy, 36 (2), 99– 100.
  • Tanaka, T., Zhang, H., Jiang, Z.H., & Kouno, I. (1997). Relationship between hydrophobicity and structure of hydrolysable tannins, and association of tannins with crude drug constituents in aqueous solution. Chemical and Pharmaceutical Bullutin, 45, 1891-1897.
  • Tang, W., & Eisenbrand, G. (1992). Chinese drugs of plant origin. chemistry, pharmacology, and use in traditional and modern medicine. Springer-Verlag. Berlin, 1.
  • Unschuld, P.U. (1988). Culture and pharmaceutics: some epistemological observations on pharmacological systems in ancient Europe and Medieval China. In: The context of medicines in developing countries. Studies in pharmaceutical anthropology. Kluwer Academic Publishers. Dordrecht, pp. 188.
  • Weli, A.M., Al-Saadia, H.S., Al-Fudhaili, R.S., Hossain, M.A., Putit, Z.B., & Jasim, M.K. (2020). Cytotoxic and antimicrobial potential of different leaves extracts of R. fruticosus used traditionally to treat diabetes. Toxicology Reports, 7, 183–187.
  • Zarawska, E.L. (1997). Biflavonoids in Juniperus species (Cupressaceae). Polish Journal of Pharmacology and Pharmacy, 27(1), 81–87.

Review on phytochemicals and biological activities of natural sweeteners Stevia rebaudiana Bertoni

Yıl 2022, Cilt: 9 Sayı: 4, 415 - 425, 21.12.2022
https://doi.org/10.21448/ijsm.1122618

Öz

Diabetes is a chronic metabolic disease that creates high blood sugar level. Therefore, diabetes awareness is necessary to prevent diabetes by reducing sugar intake and using low-calorie alternative sweeteners instead. Stevia rebaudiana is a medicinal plant species belonging to the Compositae family. It is a sweet herb that contains diterpene glycosides, which are directly responsible for the sweet taste, but they have no caloric value. Since ancient times, there have been several reports on the use of S. rebaudiana as an alternative sweetener and extended research has been conducted on its phytochemicals and biological activities. The plant contains a good number of phytochemicals with significant biological activities, namely polyphenolic derivatives, diterpenes glycosides, alkaloids, glycosides, tannins, chlorophylls, carotenoids, etc. For industrial use, those phytochemicals could be extracted from the selected plant and used for the preparation of nutraceuticals and food additives. S. rebaudiana is a natural herb; therefore, it has fewer or minimal adverse effects on human health. The selected plant in various forms is used for the treatment of diabetes, colon cancer, obesity, cavities, and others. However, the literature review shows that the information on this plant and its uses is not systematic. The purpose of the present review is to explore the status of phytochemicals and biological activities of the selected plant for young researchers. Therefore, the updated data will help them to develop new nutraceuticals and food additives that could help in the production of pharmaceuticals to treat different ailments.

Proje Numarası

N/A

Kaynakça

  • Abdulsattar, A.M., & Hossain, M.A. (2020). Antibacterial and antioxidant potential of Tetraena simplex extracts of various polarities. Toxicology Reports 7, 925–929.
  • Ahmad, U., & Ahmad, R.S. (2018). Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats. BMC Complementary and Alternative Medicine, 18, 179-185.
  • Al-Habsi, A.A.S., & Hossain, M.A. (2018). Isolation, structure characterization and prediction of antioxidant activity of two new compounds from the leaves of Dodonaea viscosa native to the Sultanate of Oman. Egyptian Journal of Basic Applied Sciences, 5, 157–164.
  • AL-Jabri, N.N., & Hossain, M.A. (2018). Chemical composition and antimicrobial potency of locally grown lemon essential oil against selected bacterial strains. Journal of King Saud University Sciences, 30, 14-20.
  • Al-Jadidi, H.S.K., & Hossain, M.A. (2016). Determination of the total phenols, flavonoids and antimicrobial activity of the crude extracts from locally grown neem stems. Asian Pacific Journal of Tropical Diseases, 6(5), 376-379.
  • AL-Oraimi, A.A., & Hossain, M.A. (2016). In vitro total flavonoids content and antimicrobial capacity of different organic crude extracts of Dodonaea viscosa. Journal of Biologically Active Products from Nature, 6(2), 166-172.
  • Al-Qassabi, J.S.A., Weli, A.M., & Hossain, M.A. (2018). Comparison of total phenols content and antioxidant potential of peel extracts of local and imported lemons samples. Sustainable Chemistry and Pharmacy, 8, 71–75.
  • Al-Rashdi, R.S.Y., Hossain. M.A., & Al-Touby, S.S.J. (2021). Antioxidant and antibacterial activities of leaves crude extracts of Adenium obesum grown in Oman National Botanical Garden. Advances in Biomarkar Science and Technology, 3, 8-14.
  • Al-Saeedi, A.H., Al-Ghafri, M.T.H., & Hossain, M.A. (2016). Comparative evaluation of total phenols, flavonoids content and antioxidant potential of leaves and fruit extracts of Omani Ziziphus jujuba L. Pacific Science. Review A: Natural Science and Engineering, 18, 78-83.
  • Al-Saeghi, S.S., Hossain, M.M., & Al-Touby, S.S.J. (2022). Characterization of antioxidant and antibacterial compounds from the aerial parts of Haplophyllum tuberculatum. Journal Bioresources and Bioproducts, 7, 52-62.
  • Amri, F.S., & Hossain, M.A. (2018). Comparison of total phenols, flavonoids and antioxidant potential of local and imported ripe bananas. Egyptian Journal of Basic Applied Sciences, 5, 245-251.
  • Barriocanal, L., Palacios, M., Benitez, G., Benitez, S., Jimenez, J., & Jimenez, N. (2008). Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans, a pilot study of repeated exposures in some normotensive and hypotensive individuals and in type 1and type 2 diabetics. Regulatory Toxicology and Pharmacology, 51, 37–41.
  • Bemays, E.A., & Chapman, R.F. (1994). Host plant selection by phytophagous insects. Chapman and Hall, NY. USA.
  • Beutler, J.A., Caredelline, J.H., McMahon, J.B., Shoemaker, R.H., & Boyd, M.R. (1995). Phytochemistry of medicinal plants. ed. Amason J. T., Mata R., Romeo J. T. Plenum Press, NY, USA.
  • Brandle, J.E., Starratt, A.N., & Gijzen, M. (1998). Stevia rebaudiana: Its agricultural, biological, and chemical properties. Canadian Journal of Plant Science, 78, 527–536.
  • Carneiro, J.W.P. (1930). Stevia rebaudiana (Bert.) Bertoni: produção de sementes. UEM: Maringá. 61.
  • Curi, R., Alvarez, M., & Bazotte, R.B. (1986). Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Brazilian Journal of Medical and Biological Research, 19(6),771–774.
  • Das, S., Das, A.K., & Murphy, R.A. (1992). Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebaudioside A. Caries Research, 26(5), 363–366.
  • Dhasarathan, P., & Theriappan, P. (2011). Evaluation of anti-diabetic activity of Strychonous potatorum in alloxan induced diabetic rats. Journal of Medical Science, 2(2), 670–674.
  • Gonsumer. (2019). National Technical Information Services. 5285 Port Royal Road, Springfield, VA 22161, pp. 152–157.
  • Genus Jan, M.C. (2002). Safety evaluation of stevia and Stevioside. Journal of Natural Product Chemistry, 27(8), 299–319.
  • Goyal, S.K., Samsher, N., & Goyal, R.K. (2010). Stevia (Stevia rebaudiana) a bio-sweetener: a review. International Journal of Food Science and. Nutrition, 61(1), 1–10.
  • Hossain, M.A., Alrashdi, Y.B.A., & Al-Touby, S.S.J. (2022). A review on essential oil analyses and biological activities of the traditionally used medicinal plant Thymus vulgaris L. International Journal of Secondary Metabolite, 9(1), 103–111.
  • Hossain, M.A., Weli, A.M., & Ahmed, S.H.I. (2019). Comparison of total phenols, flavonoids and antioxidant activity of various crude extracts of Hyoscyamus gallagheri traditionally used for the treatment of epilepsy. Clinical Phytoscience, 5, 20-29.
  • Hutapea, A.M. (1997). Digestion of stevioside (a natural sweetener) by various digestive enzymes. Journal of Clinical Biochemistry and Nutrition, 23(3), 177–186.
  • Isman, M.B. (1994). Botanical insecticides. Pesticides Outline, 5, 26-30.
  • Jan, S.A., Habib, N., & Shinwari, Z.K. (2020). The anti-diabetic activities of natural sweetener plant Stevia: an updated review. SN Applied Science, 3, 517-520.
  • Jeppesen, P.B., Gregersen, S., & Poulsen, C.R. (2000). Stevioside acts directly on pancreatic beta cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism, 49(2), 208–214.
  • Kakkar, S., & Bais, S. (2014). A review on protocatechuic acid and its pharmacological potential. ISRN Pharmacy, 9, 2014-2020.
  • Katayama, O., Sumida, T., Hayashi, H., & Mitsuhashi, H. (1976). The practical application of Stevia and research and development data, I.S.U. Company, Japan, p.747
  • Klayman, D. (1985). Qinghaosu (Artemisinin) an antimalarial from China. Science, 228, 1048-1055.
  • Kobus-Moryson, M., & Gramza-Michałowska, A. (2015). Directions on the use of stevia leaves (Stevia rebauidana) as an additive in food products. Acta Scientiarum Polonorum Technologia Alimentaria, 14(1), 5–13.
  • Lemus-Mondaca, R., Vega-Galvez, A., Zura-Bravo, L., & Ah-Hen, K. (2012). Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chemistry, 132, 1121–1132.
  • Madan, S., Ahmad, S., Singh, G.N., Kohli, K., Kumar, Y., Singh, R., & Garg, M. (2010). Stevia rebaudiana (Bert.) Bertoni – A review. Indian Journal of Natural Products Resources, 1, 267-86.
  • Maisa, S., Al-Touby, S.S.J., & Hossain, M.A. (2021). Total phenols content and antioxidant activity of different polarity crude extracts of Dodonaea viscosa. Indian Drugs. 58 (08), 79-83.
  • Mann, T.S., Agnihotri, V.K., Kumar, D., Pal, P.K., Koundal, R., Kumar, A., & Padwad, Y.S. (2014). In vitro cytotoxic activity guided essential oil composition of flowering twigs of Stevia rebaudiana. Natural Product Communications, 9(5), 715–718
  • Meireles, M.A.A., Wang, G., Hao, Z., Shima, K., & Silva, J.A.T. (2006). Stevia (Stevia rebaudiana Bertoni): futuristic view of the sweeter side of life. In: Jaime A. Teixeira da Silva ed. Floriculture, ornamental and plant biotechnology: Advances and Topical Issues IV, Edition: 1, Global Science Books 416- 425.
  • Misra, H., Soni, M., Silawat, N., Mehta, D., Mehta, B.K., & Jain, D.C. (2011). Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats. Journal of Pharmacy and Bioallied Sciences, 3(2), 242–8.
  • Phillipson, J.D., & Wright, C.W. (1991). Can ethnopharmacology contribute to the development of antimalarial agents. Journal of Ethnopharmacology, 32, 155-165.
  • Rana, N., & Bais, S. (2014). Neuroprotective effect of J. communis in Parkinson disease induced animal models, Pharmacology Department, Punjab Technical University, Punjab, India.
  • Robinson, B.L. (1930). Contribution from Gray Herbarium of Harvard University, The Gray Herbarium of Harvard University, Cambridge.
  • Saravanan, R., Vengatash B.K., & Ramachandran, V. (2012). Effect of Rebaudioside A, a diterpenoid on glucose homeostasis in STZ-induced diabetic rats. Journal of Physiology and Biochemistry, 68(3), 421–431.
  • Schoonhoven, L.M. (1982). Biological aspects of antifeedants. Entomolgia Experimentalis et Applcata, 31, 57-69.
  • Shivanna, N., Naika, M., Khanum, F., & Kaul, V.K. (2013). Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. Journal of Diabetes Complications, 27(2), 103–113.
  • Siddique, A.B., Rahman, S.M.M., Hossain, M.A., & Rashid, M.A. (2014). Phytochemical screening and comparative antimicrobial potential of different extracts of Stevia rebaudiana Bertoni leaves. Asian Pacific Journal of Tropical Diseases, 4(4), 275–280.
  • Soejarto, D.D, Kinghorn, A.D., & Farnsworth, N.R. (1982). Potencial sweetening agentsof plant origin. III. Organoleptic evaluation of Stevia leaf herbarium samples for sweetness. Journal of Natural Products, 45, 590–599.
  • Steven, D., & Ehrlich, N.M.D. (2009). Solutions acupuncture, a private practice specializing in complementary and alternative medicine. Healthcare Network, Phoenix, Ariz, USA.
  • Tandon, V., Kapoor, K., & & Gupta, B.M. (2004). Herbal drug research in India: a trend analysis using IJP as a marker. Indian Journal of Pharmacy, 36 (2), 99– 100.
  • Tanaka, T., Zhang, H., Jiang, Z.H., & Kouno, I. (1997). Relationship between hydrophobicity and structure of hydrolysable tannins, and association of tannins with crude drug constituents in aqueous solution. Chemical and Pharmaceutical Bullutin, 45, 1891-1897.
  • Tang, W., & Eisenbrand, G. (1992). Chinese drugs of plant origin. chemistry, pharmacology, and use in traditional and modern medicine. Springer-Verlag. Berlin, 1.
  • Unschuld, P.U. (1988). Culture and pharmaceutics: some epistemological observations on pharmacological systems in ancient Europe and Medieval China. In: The context of medicines in developing countries. Studies in pharmaceutical anthropology. Kluwer Academic Publishers. Dordrecht, pp. 188.
  • Weli, A.M., Al-Saadia, H.S., Al-Fudhaili, R.S., Hossain, M.A., Putit, Z.B., & Jasim, M.K. (2020). Cytotoxic and antimicrobial potential of different leaves extracts of R. fruticosus used traditionally to treat diabetes. Toxicology Reports, 7, 183–187.
  • Zarawska, E.L. (1997). Biflavonoids in Juniperus species (Cupressaceae). Polish Journal of Pharmacology and Pharmacy, 27(1), 81–87.
Toplam 53 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Makaleler
Yazarlar

Md Amzad Hossain 0000-0002-8970-0702

Said Al Harthy Bu kişi benim 0000-0002-0152-0265

Salem Said Al Touby Bu kişi benim 0000-0002-3116-9023

Proje Numarası N/A
Yayımlanma Tarihi 21 Aralık 2022
Gönderilme Tarihi 28 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 9 Sayı: 4

Kaynak Göster

APA Hossain, M. A., Al Harthy, S., & Said Al Touby, S. (2022). Review on phytochemicals and biological activities of natural sweeteners Stevia rebaudiana Bertoni. International Journal of Secondary Metabolite, 9(4), 415-425. https://doi.org/10.21448/ijsm.1122618
International Journal of Secondary Metabolite

e-ISSN: 2148-6905