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A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities

Yıl 2023, Cilt: 10 Sayı: 1, 137 - 146, 26.03.2023
https://doi.org/10.21448/ijsm.1132549

Öz

Medicinal plants have played an important influence in the development of human society; they were always at the forefront of all cultures and civilizations as a source of medicine. Medicinal plants are considered rich sources of secondary compounds, and many modern medications are derived from them. Hammada scoparia is a medicinal plant that belongs to the Chenopodiaceae family. It is currently found in North Africa (Morocco, Algeria, Libya, and Egypt) and has many medicinal properties used as folk medicine. The present research discusses the phytochemical components and biological activities of Hammada scoparia. The corresponding data were collected from various online databases, new research, and published resources. Different secondary compounds from the species have been documented, including flavonoids, tannins, alkaloids, terpenoids, and saponins. Pharmacological research has demonstrated that the major bioactives have antimicrobial, antioxidant, cytotoxic, and antimalarial activities and anticancer, reno-protective, and hepatoprotective effects. In conclusion, this study provides much information about the interests of vegetal species: Hammada scoparia.

Kaynakça

  • Balasundari, T., & Boominathan, M. (2018). Screening of bioactive compounds by GC-MS, antimicrobial activity and in silico studies in Cynodon dactylon l. Pers leaves. World Journal of Science and Research, 3(1), 7–15.
  • Benkherara, S., Bordjiba, O., Harrat, S., & Djahra, A.B. (2021). Antidiabetic Potential and Chemical Constituents of Haloxylon scoparium Aerial Part, An Endemic Plant from Southeastern Algeria. International Journal of Secondary Metabolite, 8(4), 398–412. https://doi.org/10.21448/ijsm.990569
  • Bouaziz, A., Mhalla, D., Zouari, I., Jlaiel, L., Tounsi, S., Jarraya, R., & Trigui, M. (2016). Antibacterial and antioxidant activities of Hammada scoparia extracts and its major purified alkaloids. South African Journal of Botany, 105, 89 96. https://doi.org/10.1016/j.sajb.2016.03.012
  • Boucherit, Benaradj, H., Boughalem M, & Benabdeli K. (2018). Ethnobotanical study of Hammada scoparia (Pomel) Iljin in the region of Naâma (south-western Algeria). Arabian Journal of Medicinal & Aromatic Plants, 4(2), 66.
  • Boucherit, H., Benabdeli, K., Benaradj, A., & Boughalem, M. (2018). Phytoecology of Hammada scoparia in the region of naâma (Western Algeria). Botanica Complutensis, 42, 93–99. https://doi.org/10.5209/BOCM.61371
  • Boulanouar, B., Abdelaziz, G., Aazza, S., Gago, C., & Miguel, M.G. (2013). Antioxidant activities of eight Algerian plant extracts and two essential oils. Industrial Crops and Products, 46, 85–96. https://doi.org/10.1016/j.indcrop.2013.01.020
  • Bourogaa, E., Bertrand, J., Despeaux, M., Jarraya, R., Fabre, N., Payrastre, L., Demur, C., Fournié, J.J., Damak, M., Feki, A. el, & Racaud-Sultan, C. (2011). Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells. Leukemia Research, 35(8), 1093–1101. https://doi.org/10.1016/j.leukres.2010.12.011
  • Chao, H.C., Najjaa, H., Villareal, M.O., Ksouri, R., Han, J., Neffati, M., & Isoda, H. (2013). Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells. Experimental Dermatology, 22(2), 131–136. https://doi.org/10.1111/EXD.12089
  • Djahra, A.B., Khaoula, Z., Ahmed, G., Mounia, B., khaoula, Z., Salah, B., Katrenada, O., & Khaoula, J. (2018). Evaluation of total phenolic contents and antioxidant potentials of ten medicinal plants from Algerian Sahara. International Journal of Biological and Agricultural Research , 1(2), 28–36.
  • Eddouks, M., Maghrani, M., Lemhadri, A., Ouahidi, M.L., & Jouad, H. (2002). Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). Journal of Ethnopharmacology, 82, 97–103. https://doi.org/10.1016/S0378-8741(02)00164-2
  • Édouard, Boulos Loutfy, & Vela Errol. (2010). Catalogue synonymique commenté de la flore de Tunisie (Djemali M’naouer, Ed.; 2nd ed.). Banque Nationale de Gènes,pp 500 .
  • El-Hadri, Y. (2019). Contribution à l’étude ethnobotanique des plantes médicinales utilisées dans la région de Beni Mellal-Khenifra [Thèse de Doctorat]. Université Mohammed V de Rabat, pp 194. http://ao.um5s.ac.ma/xmlui/handle/123456789/17236
  • El-Shazly, A., & Wink, M. (2003). Tetrahydroisoquinoline and-Carboline Alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). Verlag der Zeitschrift für Naturforschung, 58(7), 477–480. https://doi.org/10.1515/znc-2003-7-805
  • Ezzeddine, B., Raoudha, J.M., Mohamed, D., & Abdelfattah, E.F. (2016). Therapeutic Efficacy of Hammada scoparia Extract Against Ethanol Induced Renal Dysfunction in Wistar Rats. Journal of Food Biochemistry, 41(2), 1–8. https://doi.org/10.1111/jfbc.12307
  • Fatehi N., Allaoui M., Berbaoui H., Cheriti A., Boulenouar N., & Belboukhari N. (2018). Haloxylon Scoparium: An Ethnopharmacological Survey, Phytochemical Screening and Antibacterial Activity against Human Pathogens Causing Nosocomial Infection. PhytoChem & BioSub Journal, 11(2), 104–109.
  • Gelin, Z., Mosyakin, S.L., & Clemants, S.E. (2003). Chenopodiaceae. Flora of China, 5(1), 351-414.
  • Hafidha, B., Khéloufi, B., & Abdelkrim, B. (2017). Caracterisation floristique de la steppe a Hammada scoparia dans l’Atlas Saharien Oranais (Naama-Algerie). Revue Agrobiologia, 7(2), 483–490.
  • Hamza, N., Berke, B., Umar, A., Cheze, C., Gin, H., & Moore, N. (2019). A review of Algerian medicinal plants used in the treatment of diabetes. Journal of Ethnopharmacology, 238,1-111. https://doi.org/10.1016/j.jep.2019.111841
  • Heklau, H., Gasson, P., Schweingruber, F., & Baas, P. (2012). Wood anatomy of Chenopodiaceae (Amaranthaceae s. L.). IAWA Journal, 33(2), 205–232.
  • Kamatou, G.P.P., Makunga, N.P., Ramogola, W.P.N., & Viljoen, A.M. (2008). South African Salvia species: A review of biological activities and phytochemistry. Journal of Ethnopharmacology, 119(3), 664–672. https://doi.org/10.1016/j.jep.2008.06.030
  • Karous, O., Yousfi Aichi, H., ben Haj Jilani, I., & Ghrabi-gammar, Z. (2020). Volatiles profiling, phytotoxic activity, and antioxidant potentiality of Hammada scoparia (Pomel) Iljin extracts from southern Tunisia. Journal of New Sciences, Agriculture and Biotechnology, 70(3), 4290–4298.
  • Kharchoufa, L., Bouhrim, M., Bencheikh, N., el Assri, S., Amirou, A., Yamani, A., Choukri, M., Mekhfi, H., & Elachouri, M. (2020). Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents. BioMed Research International. https://doi.org/10.1155/2020/4020647
  • Lachkar, N., Lamchouri, F., Bouabid, K., Boulfia, M., Senhaji, S., Stitou, M., & Toufik, H. (2021). Mineral Composition, Phenolic Content, and in Vitro Antidiabetic and Antioxidant Properties of Aqueous and Organic Extracts of Haloxylon scoparium Aerial Parts. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/9011168
  • Laib, I., & Djahra, A.B. (2022). Phytochemical investigation of Helianthemum lippii l. aerial Dum.Cours part and evaluation for its antioxidant activities. International Journal of Secondary Metabolite, 09(02), 229–237. https://doi.org/10.21448/IJSM.999518
  • Lamchouri, F., Benali, T., Bennani, B., Toufik, H., Ibn, L., Hassani, M., Bouachrine, M., Lyoussi, B., Ben, M., & Maroc, A. (2012). Preliminary phytochemical and antimicrobial investigations of extracts of Haloxylon scoparium. Journal of Materials and Environmental Science, 3(4), 754–759.
  • Licá, I.C.L., Soares, A.M. dos S., de Mesquita, L.S.S., & Malik, S. (2018). Biological properties and pharmacological potential of plant exudates. Food Research International, 105, 1039–1053. https://doi.org/10.1016/j.foodres.2017.11.051
  • Nounah, I., Hajib, A., Harhar, H., Gharby, S., Kartah, B., Charrouf, Z., & Bougrin, K. (2019). Moroccan Journal of Chemistry Phytochemical Screening and Biological Activity of Leaves and stems extract of Hammada Scoparia. Moroccan Journal of Chemistry, 7, 1–009.
  • Ozenda P. (2004). Flore et végétation du Sahara (3 éme édition). BARNÉOUD, pp 662.
  • Sabrina, D., Boual, Z., Abdellah, K., Sabrine, D., Rokaia, C., Zakaria, B., Salah Eddine, S., Salah, M., El, O., Aminata, H.-K., Elhadj, O., & Didi, M. (2014). Recherche et identification de quelques plantes médicinales à caractère hypoglycémiant de la pharmacopée traditionnelle des communautés de la vallée du M’Zab (Sahara septentrional Est Algérien). Journal of Advanced Research in Science and Technology, 1(1), 1–5.
  • Saidi, S.A., Bourogâa, E., Bouaziz, A., Mongi, S., Chaaben, R., Jamoussi, K., Mezghani-Jarraya, R., van Pelt, J., & El-Feki, A. (2015). Protective effects of Hammada scoparia flavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion. Pharmaceutical Biology, 53(12), 1810 1817. https://doi.org/10.3109/13880209.2015.1010737
  • Salah, H. ben, Jarraya, R., Martin, M.-T., Veitch, N.C., Grayer, R.J., Simmonds, M.S.J., & Damak, M. (2002). Flavonol Triglycosides from the Leaves of Hammada scoparia (POMEL) ILJIN. Chemical and Pharmaceutical Bulletin, 50(9), 1268–1270.
  • Taïbi, K., Abderrahim, L.A., Ferhat, K., Betta, S., Taïbi, F., Bouraada, F., & Boussaid, M. (2020). Ethnopharmacological study of natural products used for traditional cancer therapy in Algeria. Saudi Pharmaceutical Journal, 28(11), 1451 1465. https://doi.org/10.1016/j.jsps.2020.09.011
  • Taïbi, K., Ait Abderrahim, L., Helal, F., & Hadji, K. (2021). Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria. Saudi Pharmaceutical Journal, 29(1), 43–52. https://doi.org/10.1016/j.jsps.2020.12.004
  • Taïr, K., Kharoubi, O., Taïr, O.A., Hellal, N., Benyettou, I., & Aoues, A. (2016). Aluminium-induced acute neurotoxicity in rats: Treatment with aqueous extract of Arthrophytum (Hammada scoparia). Journal of Acute Disease, 5(6), 470 482. https://doi.org/10.1016/J.JOAD.2016.08.028
  • Zerriouh, M., Zerriouh, M., Merghache, S., Djazin, R., Selles, C., & Sekkal, F.Z. (2014). Investigation of Hammada scoparia antidiabetic activity and toxicity in rat. International Journal of Phytomedicine, 6(3), 327–334.

A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities

Yıl 2023, Cilt: 10 Sayı: 1, 137 - 146, 26.03.2023
https://doi.org/10.21448/ijsm.1132549

Öz

Medicinal plants have played an important influence in the development of human society; they were always at the forefront of all cultures and civilizations as a source of medicine. Medicinal plants are considered rich sources of secondary compounds, and many modern medications are derived from them. Hammada scoparia is a medicinal plant that belongs to the Chenopodiaceae family. It is currently found in North Africa (Morocco, Algeria, Libya, and Egypt) and has many medicinal properties used as folk medicine. The present research discusses the phytochemical components and biological activities of Hammada scoparia. The corresponding data were collected from various online databases, new research, and published resources. Different secondary compounds from the species have been documented, including flavonoids, tannins, alkaloids, terpenoids, and saponins. Pharmacological research has demonstrated that the major bioactives have antimicrobial, antioxidant, cytotoxic, and antimalarial activities and anticancer, reno-protective, and hepatoprotective effects. In conclusion, this study provides much information about the interests of vegetal species: Hammada scoparia.

Kaynakça

  • Balasundari, T., & Boominathan, M. (2018). Screening of bioactive compounds by GC-MS, antimicrobial activity and in silico studies in Cynodon dactylon l. Pers leaves. World Journal of Science and Research, 3(1), 7–15.
  • Benkherara, S., Bordjiba, O., Harrat, S., & Djahra, A.B. (2021). Antidiabetic Potential and Chemical Constituents of Haloxylon scoparium Aerial Part, An Endemic Plant from Southeastern Algeria. International Journal of Secondary Metabolite, 8(4), 398–412. https://doi.org/10.21448/ijsm.990569
  • Bouaziz, A., Mhalla, D., Zouari, I., Jlaiel, L., Tounsi, S., Jarraya, R., & Trigui, M. (2016). Antibacterial and antioxidant activities of Hammada scoparia extracts and its major purified alkaloids. South African Journal of Botany, 105, 89 96. https://doi.org/10.1016/j.sajb.2016.03.012
  • Boucherit, Benaradj, H., Boughalem M, & Benabdeli K. (2018). Ethnobotanical study of Hammada scoparia (Pomel) Iljin in the region of Naâma (south-western Algeria). Arabian Journal of Medicinal & Aromatic Plants, 4(2), 66.
  • Boucherit, H., Benabdeli, K., Benaradj, A., & Boughalem, M. (2018). Phytoecology of Hammada scoparia in the region of naâma (Western Algeria). Botanica Complutensis, 42, 93–99. https://doi.org/10.5209/BOCM.61371
  • Boulanouar, B., Abdelaziz, G., Aazza, S., Gago, C., & Miguel, M.G. (2013). Antioxidant activities of eight Algerian plant extracts and two essential oils. Industrial Crops and Products, 46, 85–96. https://doi.org/10.1016/j.indcrop.2013.01.020
  • Bourogaa, E., Bertrand, J., Despeaux, M., Jarraya, R., Fabre, N., Payrastre, L., Demur, C., Fournié, J.J., Damak, M., Feki, A. el, & Racaud-Sultan, C. (2011). Hammada scoparia flavonoids and rutin kill adherent and chemoresistant leukemic cells. Leukemia Research, 35(8), 1093–1101. https://doi.org/10.1016/j.leukres.2010.12.011
  • Chao, H.C., Najjaa, H., Villareal, M.O., Ksouri, R., Han, J., Neffati, M., & Isoda, H. (2013). Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells. Experimental Dermatology, 22(2), 131–136. https://doi.org/10.1111/EXD.12089
  • Djahra, A.B., Khaoula, Z., Ahmed, G., Mounia, B., khaoula, Z., Salah, B., Katrenada, O., & Khaoula, J. (2018). Evaluation of total phenolic contents and antioxidant potentials of ten medicinal plants from Algerian Sahara. International Journal of Biological and Agricultural Research , 1(2), 28–36.
  • Eddouks, M., Maghrani, M., Lemhadri, A., Ouahidi, M.L., & Jouad, H. (2002). Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). Journal of Ethnopharmacology, 82, 97–103. https://doi.org/10.1016/S0378-8741(02)00164-2
  • Édouard, Boulos Loutfy, & Vela Errol. (2010). Catalogue synonymique commenté de la flore de Tunisie (Djemali M’naouer, Ed.; 2nd ed.). Banque Nationale de Gènes,pp 500 .
  • El-Hadri, Y. (2019). Contribution à l’étude ethnobotanique des plantes médicinales utilisées dans la région de Beni Mellal-Khenifra [Thèse de Doctorat]. Université Mohammed V de Rabat, pp 194. http://ao.um5s.ac.ma/xmlui/handle/123456789/17236
  • El-Shazly, A., & Wink, M. (2003). Tetrahydroisoquinoline and-Carboline Alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). Verlag der Zeitschrift für Naturforschung, 58(7), 477–480. https://doi.org/10.1515/znc-2003-7-805
  • Ezzeddine, B., Raoudha, J.M., Mohamed, D., & Abdelfattah, E.F. (2016). Therapeutic Efficacy of Hammada scoparia Extract Against Ethanol Induced Renal Dysfunction in Wistar Rats. Journal of Food Biochemistry, 41(2), 1–8. https://doi.org/10.1111/jfbc.12307
  • Fatehi N., Allaoui M., Berbaoui H., Cheriti A., Boulenouar N., & Belboukhari N. (2018). Haloxylon Scoparium: An Ethnopharmacological Survey, Phytochemical Screening and Antibacterial Activity against Human Pathogens Causing Nosocomial Infection. PhytoChem & BioSub Journal, 11(2), 104–109.
  • Gelin, Z., Mosyakin, S.L., & Clemants, S.E. (2003). Chenopodiaceae. Flora of China, 5(1), 351-414.
  • Hafidha, B., Khéloufi, B., & Abdelkrim, B. (2017). Caracterisation floristique de la steppe a Hammada scoparia dans l’Atlas Saharien Oranais (Naama-Algerie). Revue Agrobiologia, 7(2), 483–490.
  • Hamza, N., Berke, B., Umar, A., Cheze, C., Gin, H., & Moore, N. (2019). A review of Algerian medicinal plants used in the treatment of diabetes. Journal of Ethnopharmacology, 238,1-111. https://doi.org/10.1016/j.jep.2019.111841
  • Heklau, H., Gasson, P., Schweingruber, F., & Baas, P. (2012). Wood anatomy of Chenopodiaceae (Amaranthaceae s. L.). IAWA Journal, 33(2), 205–232.
  • Kamatou, G.P.P., Makunga, N.P., Ramogola, W.P.N., & Viljoen, A.M. (2008). South African Salvia species: A review of biological activities and phytochemistry. Journal of Ethnopharmacology, 119(3), 664–672. https://doi.org/10.1016/j.jep.2008.06.030
  • Karous, O., Yousfi Aichi, H., ben Haj Jilani, I., & Ghrabi-gammar, Z. (2020). Volatiles profiling, phytotoxic activity, and antioxidant potentiality of Hammada scoparia (Pomel) Iljin extracts from southern Tunisia. Journal of New Sciences, Agriculture and Biotechnology, 70(3), 4290–4298.
  • Kharchoufa, L., Bouhrim, M., Bencheikh, N., el Assri, S., Amirou, A., Yamani, A., Choukri, M., Mekhfi, H., & Elachouri, M. (2020). Acute and Subacute Toxicity Studies of the Aqueous Extract from Haloxylon scoparium Pomel (Hammada scoparia (Pomel)) by Oral Administration in Rodents. BioMed Research International. https://doi.org/10.1155/2020/4020647
  • Lachkar, N., Lamchouri, F., Bouabid, K., Boulfia, M., Senhaji, S., Stitou, M., & Toufik, H. (2021). Mineral Composition, Phenolic Content, and in Vitro Antidiabetic and Antioxidant Properties of Aqueous and Organic Extracts of Haloxylon scoparium Aerial Parts. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2021/9011168
  • Laib, I., & Djahra, A.B. (2022). Phytochemical investigation of Helianthemum lippii l. aerial Dum.Cours part and evaluation for its antioxidant activities. International Journal of Secondary Metabolite, 09(02), 229–237. https://doi.org/10.21448/IJSM.999518
  • Lamchouri, F., Benali, T., Bennani, B., Toufik, H., Ibn, L., Hassani, M., Bouachrine, M., Lyoussi, B., Ben, M., & Maroc, A. (2012). Preliminary phytochemical and antimicrobial investigations of extracts of Haloxylon scoparium. Journal of Materials and Environmental Science, 3(4), 754–759.
  • Licá, I.C.L., Soares, A.M. dos S., de Mesquita, L.S.S., & Malik, S. (2018). Biological properties and pharmacological potential of plant exudates. Food Research International, 105, 1039–1053. https://doi.org/10.1016/j.foodres.2017.11.051
  • Nounah, I., Hajib, A., Harhar, H., Gharby, S., Kartah, B., Charrouf, Z., & Bougrin, K. (2019). Moroccan Journal of Chemistry Phytochemical Screening and Biological Activity of Leaves and stems extract of Hammada Scoparia. Moroccan Journal of Chemistry, 7, 1–009.
  • Ozenda P. (2004). Flore et végétation du Sahara (3 éme édition). BARNÉOUD, pp 662.
  • Sabrina, D., Boual, Z., Abdellah, K., Sabrine, D., Rokaia, C., Zakaria, B., Salah Eddine, S., Salah, M., El, O., Aminata, H.-K., Elhadj, O., & Didi, M. (2014). Recherche et identification de quelques plantes médicinales à caractère hypoglycémiant de la pharmacopée traditionnelle des communautés de la vallée du M’Zab (Sahara septentrional Est Algérien). Journal of Advanced Research in Science and Technology, 1(1), 1–5.
  • Saidi, S.A., Bourogâa, E., Bouaziz, A., Mongi, S., Chaaben, R., Jamoussi, K., Mezghani-Jarraya, R., van Pelt, J., & El-Feki, A. (2015). Protective effects of Hammada scoparia flavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion. Pharmaceutical Biology, 53(12), 1810 1817. https://doi.org/10.3109/13880209.2015.1010737
  • Salah, H. ben, Jarraya, R., Martin, M.-T., Veitch, N.C., Grayer, R.J., Simmonds, M.S.J., & Damak, M. (2002). Flavonol Triglycosides from the Leaves of Hammada scoparia (POMEL) ILJIN. Chemical and Pharmaceutical Bulletin, 50(9), 1268–1270.
  • Taïbi, K., Abderrahim, L.A., Ferhat, K., Betta, S., Taïbi, F., Bouraada, F., & Boussaid, M. (2020). Ethnopharmacological study of natural products used for traditional cancer therapy in Algeria. Saudi Pharmaceutical Journal, 28(11), 1451 1465. https://doi.org/10.1016/j.jsps.2020.09.011
  • Taïbi, K., Ait Abderrahim, L., Helal, F., & Hadji, K. (2021). Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria. Saudi Pharmaceutical Journal, 29(1), 43–52. https://doi.org/10.1016/j.jsps.2020.12.004
  • Taïr, K., Kharoubi, O., Taïr, O.A., Hellal, N., Benyettou, I., & Aoues, A. (2016). Aluminium-induced acute neurotoxicity in rats: Treatment with aqueous extract of Arthrophytum (Hammada scoparia). Journal of Acute Disease, 5(6), 470 482. https://doi.org/10.1016/J.JOAD.2016.08.028
  • Zerriouh, M., Zerriouh, M., Merghache, S., Djazin, R., Selles, C., & Sekkal, F.Z. (2014). Investigation of Hammada scoparia antidiabetic activity and toxicity in rat. International Journal of Phytomedicine, 6(3), 327–334.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Makaleler
Yazarlar

Chaima Benine 0000-0001-9598-0635

Ali Boutlelis Djahra 0000-0001-6046-6804

Laiche Ammar Touhami Bu kişi benim 0000-0002-0499-2153

Abdelkrim Rebiai Bu kişi benim 0000-0003-4353-7441

Yayımlanma Tarihi 26 Mart 2023
Gönderilme Tarihi 20 Haziran 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 10 Sayı: 1

Kaynak Göster

APA Benine, C., Djahra, A. B., Ammar Touhami, L., Rebiai, A. (2023). A systematic review on Hammada scoparia medicinal plant: Phytochemicals, traditional uses and biological activities. International Journal of Secondary Metabolite, 10(1), 137-146. https://doi.org/10.21448/ijsm.1132549
International Journal of Secondary Metabolite
e-ISSN: 2148-6905