Background: The plant Murraya koenigii (L.) Spreng.native to Pakistan and India and a part of the Rutaceae family, plays a vital role in the Indian Ayurvedic medicine system. Studies have shown that this plant's bark, roots, and leaves contain many carbazole alkaloids. These alkaloids are known to have substantial therapeutic properties.
Methods:
The crushed and powdered organs of M. koenigii were extracted with several solvents (acetone, chloroform, and methanol). Then, using column chromatography, a dull brown oily substance, MK- 1 (1.05 g), was obtained with chloroform and methanol (7:3).
Result
We have successfully isolated a new carbazole alkaloid, 3-geranyl 8-hydroxy 6, 7-di methoxy 3’, 3’-dimethyl 1, 2-pyranocarbazole, from the seeds of M. koenigii. The structure was further elucidated by cross-referencing our NMR, UV, IR, and MS data with that found in the published literature.
Conclusion:
Comparing the previously published literature data clearly explained that this alkaloid is new to M. koenigii.
Murraya koenigii Rutaceae Carbazole alkaloid Pyranocarbazole
Background: The plant Murraya koenigii (L.) Spreng.native to Pakistan and India and a part of the Rutaceae family, plays a vital role in the Indian Ayurvedic medicine system. Studies have shown that this plant's bark, roots, and leaves contain many carbazole alkaloids. These alkaloids are known to have substantial therapeutic properties.
Methods:
The crushed and powdered organs of M. koenigii were extracted with several solvents (acetone, chloroform, and methanol). Then, using column chromatography, a dull brown oily substance, MK- 1 (1.05 g), was obtained with chloroform and methanol (7:3).
Result
We have successfully isolated a new carbazole alkaloid, 3-geranyl 8-hydroxy 6, 7-di methoxy 3’, 3’-dimethyl 1, 2-pyranocarbazole, from the seeds of M. koenigii. The structure was further elucidated by cross-referencing our NMR, UV, IR, and MS data with that found in the published literature.
Conclusion:
Comparing the previously published literature data clearly explained that this alkaloid is new to M. koenigii.
Murraya koenigii Rutaceae Carbazole alkaloid Pyranocarbazole
Birincil Dil | İngilizce |
---|---|
Konular | Bitki Biyokimyası, Eczacılık ve İlaç Bilimleri |
Bölüm | Makaleler |
Yazarlar | |
Erken Görünüm Tarihi | 31 Temmuz 2023 |
Yayımlanma Tarihi | 27 Ağustos 2023 |
Gönderilme Tarihi | 23 Ekim 2022 |
Yayımlandığı Sayı | Yıl 2023 Cilt: 10 Sayı: 3 |