Larva Treatment From Past to Present in Chronic Wounds

Year 2020, Volume: 1 Issue: 3, 154 - 161, 15.12.2020

Esra Gül , Yashar Nurullazade , Ertuğrul Kaya

Abstract

‘’Maggot Debridement Therapy" (MDT), known as larval therapy, is one of the traditional and complementary medicine practices with a history of application from ancient times to the present day. It is used in the treatment of chronic wounds that do not heal with conventional treatments. There are many case histories of successful treatment of stubborn wounds such as diabetic foot ulcers with MDT. Since it reduces the need for antibiotics and does not have any known significant side effects, it is an FDA approved treatment method that is now frequently used. In this review study, it is aimed to explain the development steps of MDT from past to present and its application methods and to discuss its medical importance in the light of the literature.

Keywords

Lucilia Sericata, Larva, Maggot Therapy, Traditional medicine, Wound

References

• Gazi U, Özkan AT, Mumcuoğlu KY. Larval Terapi ve Kronik Yaralar. Journal of BSHR 2019;3:55-60.
• Bazaliński D, Kózka M, Karnas M, Więch P. Effectiveness of Chronic Wound Debridement with the Use of Larvae of Lucilia Sericata. J Clin Med. 2019; 8(11):1845.
• Gupta A. A review of the use of maggots in wound therapy. Ann Plast Surg. 2008; 60(2):224-7.
• Mumcuoğlu KY, Özkan AT. Süpüratif Kronik Yaraların Maggot Debridman Tedavisi. Turkiye Parazitol Derg 2009;33(4):307-315.
• Whitaker IS, Twine C, Whitaker MJ, Welck M, Brown CS, Shandall A. Larval therapy from antiquity to the present day: mechanisms of action, clinical applications and future potential. Postgrad Med J. 2007;83(980):409-13.
• Baer WS. The treatment of chronic osteomyelitis with the maggot (larva of the blow fly). J Bone Joint Surg. 1931; 13(3): 438-475. Sherman RA, Pechter EA. Maggot therapy: a review of the therapeutic applications of fly larvae in human medicine, especially for treating osteomyelitis. Med Vet Entomol. 1988;2(3):225-30.
• Nigam Y, Bexfield A, Thomas S, Ratcliffe NA. Maggot Therapy: The Science and Implication for CAM Part I – History and Bacterial Resistance. Evid-Based Compl Alt Med. 2006;3(2):223–227.
• Polat E, Çakan H, İpek T. Larva Debridman Tedavisi. Türk Aile Hek Derg. 2010;14(4):188-191.
• Orkiszewski M. Maggots of Lucilia Sericata in treatment of intractable wounds. Wiad Lek. 2007;60(7-8):381-5.
• Falch BM, Weerd L, Sundsfjord A. Maggot therapy in wound management. Tidsskr Nor Laegeforen. 2009;129(18):1864-7.
• Nenoff P, Herrmann A, Gerlach C, Herrmann J, Simon JC. Biosurgical débridement using Lucilia Sericata-maggots-an update. Wien Med Wochenschr. 2010 Dec;160(21-22):578-85.
• Raposio E, Bortolini S, Maistrello L, Grasso DA. Larval Therapy for Chronic Cutaneous Ulcers: Historical Review and Future Perspectives. Wounds. 2017;29(12):367-373.
• Mumcuoğlu KY. Clinical applications for maggots in wound care. Am J Clin Dermatol. 2001;2(4):219-27.
• Bolaban D. Lucilia Sericata Larvaları ve Salgılarının Metisiline Dirençli Staphylococcus Aureus (MRSA) ve Metisiline Duyarlı Staphylococcus Aureus (MSSA) Üzerine Antibakteriyel Etkilerinin İn-Vivo ve İn-Vitro Koşullarda Araştırılması. Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Mikrobiyoloji ve Klinik Mikrobiyoloji Ana Bilim Dalı, 2009.
• Cazander G, Pritchard DI, Nigam Y, Jung W, Nibbering PH. Multiple actions of Lucilia Sericata larvae in hard-to-heal wounds: larval secretions contain molecules that accelerate wound healing, reduce chronic inflammation and inhibit bacterial infection. Bioessays. 2013;35(12):1083-92.
• Pritchard DI, Čeřovský V, Nigam Y, Pickles SF, Cazander G, Nibbering PH, Bültemann A, Jung W. TIME management by medicinal larvae. Int Wound J. 2016;13(4):475-84.
• Zarchi K, Jemec GBE. The efficacy of maggot debridement therapy--a review of comparative clinical trials. Int Wound J. 2012;9(5):469-77.
• Yaman M, Zerek A. Miyaz Sinekleri Larvalarının Yara Tedavisinde Kullanılması. Mustafa Kemal Üniv Tıp Derg. 2017; 8(32): 20-28.
• Tanyüksel M, Koru Ö, Araz RE, Kılbaş HZG, Yıldız Ş, Alaca R, Ay H, Şimşek K, Yıldız C, Yurttaş Y, Demiralp B, Deveci M, Beşirbellioğlu BA. Kronik yaraların tedavisinde steril Lucilia Sericata larva uygulamaları. Gülhane Tıp Derg. 2014;56: 218-222.
• Thomas S, Wynn K, Fowler T, Jones M. The effect of containment on the properties of sterile maggots. Br J Nurs. 2002;11(12 Suppl):S21-2, S24, S26 passim.
• Nuesch R, Rahm G, Rudin W, Steffen I, Frei R, Rufli T, Zimmerli W. Clustering of bloodstream infections during maggot debridement therapy using contaminated larvae of Protophormia terraenovae. Infection, 2002;30(5):306-9.
• Stadler F. The maggot therapy supply chain: a review of the literature and practice. Med Vet Entomol. 2020;34(1):1-9.
• Zubir MZM, Holloway S, Noor NM. Maggot Therapy in Wound Healing: A Systematic Review. Int J Environ Res Public Health. 2020;17(17):6103.
• Yağız S, Göktaş SB. Bası Yarasında Maggot Debridman Tedavisi: Olgu Sunumu. IAAOJ,Health Science, 2015;3(2): 21-29.
• Özkan AT, Mumcuoğlu KY. Kronik venöz ülserli bir olgunun maggot debridman tedavisi ile sağaltımı. Türk Hij Den Biyol Derg. 2007; 64 (1): 31-34
• Tuğcu İ, Yavuz F, Safaz İ, Araz E, Alaca R, Tanyüksel M. Konvansiyonel Tedaviye Dirençli Sakral Bölge Bası Yarasında Maggot Terapi Uygulaması: Olgu Sunumu. FTR Bil Der. 2009;12: 93-96.
• Uçar N, Kuş FS, Fırat T. Diyabetik ayak ülserli hastada maggot debridman tedavisine ağrısız yaklaşım: olgu sunumu. IAOOJ,Health Sciense. 2018;4(1):1-7
• Choudhary V, Choudhary M, Pandey S, Chauhan VD, Hasnani JJ. Maggot debridement therapy as primary tool to treat chronic wound of animals. Vet World. 2016;9(4):403-9.