An Alternative Method to Assessment on Safety Effectiveness of Food Additives

Yıl 2022, Cilt: 6 Sayı: 2, 109 - 112, 15.12.2022

Yaşar Demir Nazan Demir Hayrunnisa Nadaroglu Meryem Uçkaya

Öz

The active sites of enzymes that interact with chemicals are three-dimensional and optically active. Taking into consideration the properties of catalytic sites, it is considered that
determining the geometric properties of the chemical substances and the functional groups that they have might make a contribution to the assessment of the safety of food additives.
To obtain the toxicological data of chemicals is a time-requiring and challenging process. Since the number of chemical compounds is significantly high, it is not possible to perform
toxicological assessment for each. Therefore, it is important to predict if toxic or not by using the formulas of chemical compounds. In this study, differences between the geometric
structures of chemical compounds (control group) constituting the nutrients were analyzed in terms of consumption and those of food additives added into the food in order to have
aroma, flavor and color, by means of group theory. This study aims to predict if food chemicals can be toxic or not using point group analysis. As a material, molecules consisting
of food additives, chemical formulas of amino acids, sugars, fatty acids, and secondary metabolites and additives used to regulate the properties of foods have been used in the study.
Two and three-dimensional structures of these formulas have been drawn and point groups have been determined. As a method, Campus-licensed versions of ChemDraw 19.0 and
Gaussian 09W have been used to draw two and three-dimensional structures of formulas and to carry out the molecular calculations respectively, which are presented by our University.
GaussView 6.0 (Free) has been used to analyze the geometrical properties of the molecules based on Group Theory.

Anahtar Kelimeler

Food Additives, Safety, Effectiveness, Group Theory, Alternative Method