jhvs İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 2147-7892 2147-7892 İnönü Üniversitesi 10.33715/inonusaglik.1163401 Clinical Sciences Klinik Tıp Bilimleri PROLIDASE LEVEL IN CORONARY ARTERY DISEASE AND ISCHEMIC MITRAL VALVE INSUFFICIENCY Koroner Arter Hastalığı ve İskemik Mitral Kapak Yetmezliğinde Prolidaz Düzeyi https://orcid.org/0000-0003-2666-6436 Ağrıç Vedat Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey https://orcid.org/0000-0003-1951-8881 Göz Mustafa BURSA ANADOLU KALP MERKEZİ https://orcid.org/0000-0001-9157-7830 Dikme Reşat HARRAN UNIVERSITY https://orcid.org/0000-0001-6863-1907 Padak Mahmut HARRAN ÜNİVERSİTESİ https://orcid.org/0000-0002-6652-6035 Aydın Mehmet Salih HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0001-7111-7503 Kankılıç Nazım HARRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0003-0320-4239 Amaç Bişar Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey 06 10 2023 11 2 1499 1506 08 17 2022 01 25 2023 Copyright © 2013, İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 2013 İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

Plasma prolidase levels change as a determining factor for coronary artery disease and heart valve insufficiency. The aim of this study is to compare plasma prolidase levels in two groups with or without mitral regurgitation who underwent coronary artery bypass surgery (CABS). For this purpose, 45 patients who underwent CABS were included in the study; patients without mitral valve insufficiency who underwent CABS (25 patients) Group 1, patients with mitral valve insufficiency who underwent CABS (20 patients) Group 2. Venous blood was taken from all patients before and after CABS and their prolidase levels were measured. Preoperative and postoperative serum prolidase levels in group 1 were 1038.2 and 1289.43 U/L, respectively. In group 2, preoperative and postoperative serum prolidase levels were 1084.07 and 1337.74 U/L, respectively. A significant difference was found between preoperative and postoperative plasma prolidase levels of Group 1 and Group 2 included in the study (p<0.05). Plasma prolidase level was high in both groups. However, pre- and postoperative serum prolidase levels were found to be higher in patients with mitral valve insufficiency in Group 2. In conclusion, in this study, it was determined that the plasma prolidase level was higher in patients with mitral valve insufficiency who underwent CABS.

Plazma prolidaz seviyeleri, koroner arter hastalığı ve kalp kapağı yetmezliği için belirleyici bir faktör olarak değişir. Bu çalışmanın amacı mitral yetersizliği olan ve olmayan koroner arter baypas cerrahisi (KABC) uygulanan iki grupta plazma prolidaz düzeylerini karşılaştırmaktır. Bu amaçla çalışmaya KABC uygulanan 45 hasta dâhil edildi; mitral kapak yetmezliği olmayan ve KABC uygulanan hastalar (25 hasta) Grup 1, mitral kapak yetmezliği olup KABC uygulanan hastalar (20 hasta) Grup 2 olarak adlandırıldı. Tüm hastalardan KABC öncesi ve sonrası venöz kan alındı ve prolidaz düzeyleri ölçüldü. Grup 1'de preoperatif ve postoperatif serum prolidaz seviyeleri sırasıyla 1038.2 ve 1289.43 U/L olarak hesaplandı. Grup 2'de ise preoperatif ve postoperatif serum prolidaz seviyeleri sırasıyla 1084,07 ve 1337.74 U/L olarak hesaplandı. Çalışmaya alınan Grup 1 ve Grup 2'nin preoperatif ve postoperatif plazma prolidaz düzeyleri arasında anlamlı fark bulundu (p<0.05). Plazma prolidaz düzeyi her iki grupta da yüksekti. Ancak Grup 2'de mitral kapak yetmezliği olan hastalarda ameliyat öncesi ve sonrası serum prolidaz düzeyleri daha yüksek bulundu. Sonuç olarak bu çalışmada mitral kapak yetersizliği nedeniyle KABC yapılan hastalarda plazma prolidaz düzeyinin daha yüksek olduğu belirlendi.

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