jhvs İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 2147-7892 2147-7892 İnönü Üniversitesi 10.33715/inonusaglik.700995 Clinical Sciences Klinik Tıp Bilimleri miRNA’LAR VE KORONER ARTER HASTALIKLARIYLA İLİŞKİLERİ Relations of mirna's and Coronary Artery Diseases https://orcid.org/0000-0001-9157-7830 Dikme Reşat HARRAN ÜNİVERSİTESİ https://orcid.org/0000-0001-6863-1907 Padak Mahmut HARRAN ÜNİVERSİTESİ https://orcid.org/0000-0002-7531-4958 Korkmaz Ersöz Ezhar HARRAN ÜNİVERSİTESİ https://orcid.org/0000-0002-4427-8149 Hacanlı Yasemin HARRAN ÜNİVERSİTESİ 04 26 2020 8 1 162 174 03 09 2020 04 15 2020 Copyright © 2013, İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi 2013 İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi

Son çalışmalar, miRNA'ların kalbin gelişimi ve düzgün çalışması için çok önemli olduğunu göstermiştir. Kalbin kardiyojenik transkripsiyon faktörleri nedeniyle ifade edilen birçok miRNA'sı vardır. Kardiyovasküler hastalıklar sırasında miRNA ekspresyonu önemli ölçüde değişir ve farklı miRNA ekspresyon seviyeleri spesifik kardiyovasküler bozukluklarla korelasyon gösterir. Bu derleme makalesi miRNA'lar hakkında ayrıntılı bilgi vererek hem klinik hem de subklinik koroner arter hastalığı ile korelasyonu hakkındaki mevcut kanıtları özetlemekte, ayrıca miRNA'ların koroner arter hastalığında potansiyel bir tanı ve prognostik biyobelirteç olarak araştırmanın gerekliliğini vurgulamaktadır.

Recent studies have established that miRNAs are crucial for the development and proper functioning of the heart. The heart has many miRNAs expressed due to cardiogenic transcription factors. During cardiovascular diseases, miRNA expression varies significantly and different miRNA expression levels are correlated with specific cardiovascular disorders. This review article provides detailed information about miRNAs, summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD.

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