Ion Channels and Regulatory Signals of Heme

Taleh Yusifov; Aysel Aliyeva; Fidan Gudratova; Nermin Aliyeva

doi:10.26650/EurJBiol.2026.1756794

Ion Channels and Regulatory Signals of Heme

Abstract

Heme is vital for life and an indispensable factor in various physiological processes. Beyond its function as a key ligand, heme serves as a multifaceted biomodulator, actively regulating diverse protein functions and cellular pathways. One of its significant functions is modulating the activity of ion channels. Heme's regulation of cellular excitability is linked to vital physiological functions, including sensitivity to oxygen and blood pressure regulation through neural signals. Furthermore, heme's impact on ion channels' role in controlling vascular processes, such as strokes or bleeding. Given the functional importance of the heme-driven action of the ion channel, further exploration is warranted, as many aspects of this process remain understudied. This brief review aims to summarize the structural organization of heme-sensitive sites within ion channels and examines the functional consequences of heme action. We think this knowledge will enhance our understanding of heme-driven modulation in ion channels.

Keywords

References

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Details

Primary Language

English

Subjects

Signal Transduction

Journal Section

Review

Authors

Taleh Yusifov ^*
0009-0002-8486-5695
Azerbaijan

Aysel Aliyeva
0009-0005-2826-0335
Azerbaijan

Fidan Gudratova
0009-0005-9597-5066
Azerbaijan

Nermin Aliyeva This is me
0009-0002-2416-3018
Azerbaijan

Publication Date

February 26, 2026

Submission Date

August 2, 2025

Acceptance Date

December 23, 2025

Published in Issue

Year 2026 Volume: 85 Number: 1

DOI

https://doi.org/10.26650/EurJBiol.2026.1756794

IZ

https://izlik.org/JA38HK63EK

Cite

RIS / Bibtex

APA

Yusifov, T., Aliyeva, A., Gudratova, F., & Aliyeva, N. (2026). Ion Channels and Regulatory Signals of Heme. European Journal of Biology, 85(1), 57-65. https://doi.org/10.26650/EurJBiol.2026.1756794

AMA

1.Yusifov T, Aliyeva A, Gudratova F, Aliyeva N. Ion Channels and Regulatory Signals of Heme. Eur J Biol. 2026;85(1):57-65. doi:10.26650/EurJBiol.2026.1756794

Chicago

Yusifov, Taleh, Aysel Aliyeva, Fidan Gudratova, and Nermin Aliyeva. 2026. “Ion Channels and Regulatory Signals of Heme”. European Journal of Biology 85 (1): 57-65. https://doi.org/10.26650/EurJBiol.2026.1756794.

EndNote

Yusifov T, Aliyeva A, Gudratova F, Aliyeva N (February 1, 2026) Ion Channels and Regulatory Signals of Heme. European Journal of Biology 85 1 57–65.

IEEE

[1]T. Yusifov, A. Aliyeva, F. Gudratova, and N. Aliyeva, “Ion Channels and Regulatory Signals of Heme”, Eur J Biol, vol. 85, no. 1, pp. 57–65, Feb. 2026, doi: 10.26650/EurJBiol.2026.1756794.

ISNAD

Yusifov, Taleh - Aliyeva, Aysel - Gudratova, Fidan - Aliyeva, Nermin. “Ion Channels and Regulatory Signals of Heme”. European Journal of Biology 85/1 (February 1, 2026): 57-65. https://doi.org/10.26650/EurJBiol.2026.1756794.

JAMA

1.Yusifov T, Aliyeva A, Gudratova F, Aliyeva N. Ion Channels and Regulatory Signals of Heme. Eur J Biol. 2026;85:57–65.

MLA

Yusifov, Taleh, et al. “Ion Channels and Regulatory Signals of Heme”. European Journal of Biology, vol. 85, no. 1, Feb. 2026, pp. 57-65, doi:10.26650/EurJBiol.2026.1756794.

Vancouver

1.Taleh Yusifov, Aysel Aliyeva, Fidan Gudratova, Nermin Aliyeva. Ion Channels and Regulatory Signals of Heme. Eur J Biol. 2026 Feb. 1;85(1):57-65. doi:10.26650/EurJBiol.2026.1756794