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Yıl 2015, Cilt: 45 Sayı: 2, 127 - 138, 22.11.2016

Nuray Ulusoy Güzeldemirci1, Dilek Şatana2, Ömer Küçükbasmacı3

Öz

Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide

Yıl 2015, Cilt: 45 Sayı: 2, 127 - 138, 22.11.2016

Nuray Ulusoy Güzeldemirci1, Dilek Şatana2, Ömer Küçükbasmacı3

Öz

Abstract: In this study, some novel N2-arylidene/cycloalkylidene-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazides (2a-d) were synthesized from (6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (1). The newly synthesized compounds were characterized by IR, 1H NMR, mass and elemental analysis. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T. mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. N2-Cyclohexylidene-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (2c) and N2-(3-methylcyclohexylidene)-(6-(4-nitrophenyl)imidazo[2,1-b]thiazol-3-yl)acetic acid hydrazide (2d) showed the highest antibacterial activity. Particularly 2c showed the highest antifungal activity against tested fungi.
Key words: Imidazo[2,1-b]thiazole, arylidene/cycloalkylidenehydrazides, antibacterial activity, antifungal activity

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Ayrıntılar

Bölüm Araştırma Makalesi
Yazarlar

Nuray Ulusoy Güzeldemirci1, Dilek Şatana2, Ömer Küçükbasmacı3

Yayımlanma Tarihi 22 Kasım 2016
Yayımlandığı Sayı Yıl 2015 Cilt: 45 Sayı: 2

Kaynak Göster

APA Dilek Şatana2, Ömer Küçükbasmacı3, N. U. G. (2016). Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Journal of Faculty of Pharmacy of Istanbul University, 45(2), 127-138.
AMA Dilek Şatana2, Ömer Küçükbasmacı3 NUG. Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Journal of Faculty of Pharmacy of Istanbul University. Ocak 2016;45(2):127-138.
Chicago Dilek Şatana2, Ömer Küçükbasmacı3, Nuray Ulusoy Güzeldemirci1,. “Synthesis and Antimicrobial Evaluation of Some New Hydrazone Derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-Acetic Acid Hydrazide”. Journal of Faculty of Pharmacy of Istanbul University 45, sy. 2 (Ocak 2016): 127-38.
EndNote Dilek Şatana2, Ömer Küçükbasmacı3 NUG (01 Ocak 2016) Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Journal of Faculty of Pharmacy of Istanbul University 45 2 127–138.
IEEE N. U. G. Dilek Şatana2, Ömer Küçükbasmacı3, “Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide”, Journal of Faculty of Pharmacy of Istanbul University, c. 45, sy. 2, ss. 127–138, 2016.
ISNAD Dilek Şatana2, Ömer Küçükbasmacı3, Nuray Ulusoy Güzeldemirci1,. “Synthesis and Antimicrobial Evaluation of Some New Hydrazone Derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-Acetic Acid Hydrazide”. Journal of Faculty of Pharmacy of Istanbul University 45/2 (Ocak 2016), 127-138.
JAMA Dilek Şatana2, Ömer Küçükbasmacı3 NUG. Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Journal of Faculty of Pharmacy of Istanbul University. 2016;45:127–138.
MLA Dilek Şatana2, Ömer Küçükbasmacı3, Nuray Ulusoy Güzeldemirci1,. “Synthesis and Antimicrobial Evaluation of Some New Hydrazone Derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-Acetic Acid Hydrazide”. Journal of Faculty of Pharmacy of Istanbul University, c. 45, sy. 2, 2016, ss. 127-38.
Vancouver Dilek Şatana2, Ömer Küçükbasmacı3 NUG. Synthesis and antimicrobial evaluation of some new hydrazone derivatives of 6-(4-nitrophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. Journal of Faculty of Pharmacy of Istanbul University. 2016;45(2):127-38.