SOME IMIDAZO[1,2-α] PYRIDINE DERIVATIVES AS POSSIBLE ANTIMYCOBACTERIALS

Yıl 1998, Cilt: 32 , 39 - 45, 09.09.2015

N. Cesur Z. Cesur

Öz

hidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlr

hidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlr

hidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlr

Anahtar Kelimeler

hydrazide-hydrazones, thiosemicarbazides, 4-thiazolidinones imidazo[l,2-a]pyridine, antituberculosis activity

SOME IMIDAZO[1,2-α] PYRIDINE DERIVATIVES AS POSSIBLE ANTIMYCOBACTERIALS

Öz

Some new hydrazide-hydrazones and 4-thiazolidinones incorporating an imidazo[l,2-α]pyridine moiety were synthesized and the new and structurally related compounds which were previously reported were screened for antituberculosis activity.The treatment of tuberculosis is still one of the major problems due to the rise of multidrug-resistant tuberculosis in clinical p;actise. In our previous stud- ,ies ,(l-3) we described the synthesis of &idazo[l,2-alpyridine-3-.c~bohydrazides and related compounds, which are structurally sdar to iso&cotinic acid hydrazide (INH), the principal drug for the treatment of tuberculosis. As a con-

Anahtar Kelimeler

hydrazide-hydrazones, thiosemicarbazides, 4-thiazolidinones imidazo, 2-α, antituberculosis activity

Kaynakça

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• 2. Cesur, N., Cesur, Z., Ergen$, N., Uzun, M.,Kiraz, M., Kaslmoglu, 0 ., Kaya, D., ibid. 327, 27 1-272 (1 994).
• 3. Cesur, N., Cesur, Z., Farnzaco 49,679-68 1 (1994).
• 4. Inderleid, C.B., Antibiotics in Laboratory Medicine, (Ed: Lorian, V.) 3rd ed. p.134-197 Williams and Wilkins, Baltimore (1991).
• 5. Hideki, 0:, Minoru, 0.. Tsutomu, Y., Hiroshi, M., PCT tnt. Appl. W0.8607,059 (1986). Ref. C.A. 106, 176381~ (1987).
• 6. Silverstein, R.M., Bassler, G.C., Mom1 T:C., Spectrometric Identification of Organic Compounds, 4th ed. p. 207-208 John Wiley and Sons, New York (1981).