FURTHER SESQUITERPENE LACTONES AND FLAVONES FROM Centaurea bruguierana

Year 1995, Volume: 31 , 25 - 28, 09.09.2015

U. Sönmez*, F.m. Harraz**, S. Öksüz***

Abstract

A further investigation of the aerial parts of Centaurea bruguierana
(DC.) Hand.-Mazz. afforded four sesquiterpene lactones namely, cnicin, 1 1,13-
dehydromelitensin, 8a-(5-hydroxy)-angeloyloxy-l l, 13-dehydromelitensin, 8a-
(3',4'-dihydroxyethy1)-acryloxy- 1 1,13-dehydromelitensin and five flavonoids;
eupatilin, 5-hydroxy-6,7,3',4'-tetramethoxyflavone, jaceosidin, pectolinarigenin
and cirsilineol. The'structures were determined by spectral methods especially
by high field NMR spectroscopy. In course of our research of the genus Ceiztaurea, we have examined Ceiztaui-ea blvguielmza (DC.) Hand.-Mazz. (Syrz. C. phllocephala Boiss.) a Saudi Arabian plant, which was distributed in Najid province of Saudi Arabia. The plant has been investigated previously by one of us, F.M. Harraz, and the presence of a germacranolide; cnicin, an eudesmanolide; 11,13-dehydromelitensin 8a-acetate and three flavonoids; circilineol, cirsimaritin and hispudilin 7-0-rutinoside were reported (1).

Keywords

Centaurea bruguielmzu, Compositae, sesquiterpene lactones, flavones

FURTHER SESQUITERPENE LACTONES AND FLAVONES FROM Centaurea bruguierana

Abstract

Centaurea bruguierana (DC.) Hand.-Mazz. bitkisinin toprak iistii luslmlanndan dort seskiterpen lakton; 1 1,13-dehydromelitensin, cnicin, 8a-(5-hidroksi)-angeloyiloksi- 1 1 , 13-dehidromelitensin 8a-(3',4'-dihidroksieti1)-akriloksi11,13-dehidromelitensin ve beg flavonoid bilegik, eupatilin, 5-hidroksi-6,7,3',4'- tetrametoksiflavon, jaceosidin, pectolinarigenin ve cirsilineol elde edilmigtir. Bilegiklerh yapllari spektroskopik yontemler ile agklanrn~g~

Centaurea bruguierana (DC.) Hand.-Mazz. bitkisinin toprak iistii luslmlanndan dort seskiterpen lakton; 1 1,13-dehydromelitensin, cnicin, 8a-(5-hidroksi)-angeloyiloksi- 1 1 , 13-dehidromelitensin 8a-(3',4'-dihidroksieti1)-akriloksi11,13-dehidromelitensin ve beg flavonoid bilegik, eupatilin, 5-hidroksi-6,7,3',4'- tetrametoksiflavon, jaceosidin, pectolinarigenin ve cirsilineol elde edilmigtir. Bilegiklerh yapllari spektroskopik yontemler ile agklanrn~g~

Keywords

Centaurea bruguielmzu, Compositae, sesquiterpene lactones, flavones

References

• 1. Harraz, F.M., Kassem, F.F. and El-Shaer, N.S. Alex. J. Parm. Sci. 8,219-222 (1994). '
• 2. Jakupovic, J., Jia, Y., Pathak, V.P., Bohlmann, F. and King, R.M. Plalzta Medica 52, 399 (1986).
• 3. Barrero, A.F., Sanchez, J.I., Rodrigez, I. and Sonia, C.An. Quim, Ser. C. 84, 344 (1988).
• 4. Bruno, M. and Herz, W.Phytoclzemistry 27,1873-1875 (1988).
• 5. Bruno, M., Fazio, C., Passananti, S., Paternostro, M.P., Diaz, J.G. and Herz, W. Phytochemishy35, 1371-1372 (1994).
• 6. Tsankova, E. and Ognyanov, I. Planta Medica 465-466 (1985).
• 7. Gonzalez, A.G., Berrnejo, J., Cabrera, I. and Massanet, G.M.An. Quim. 70, 74 (1974).
• 8. Kupchan, S.M., Sigel, C.W., Hemingway, R.J., Knox, J.R., Udayamurthy, M.S. Tetrahedron 25, 1603-1615 (1969).
• 9. Dobberstein, R.H., Tin-Wa, M., Fong, H.H.S., Crane, F.A., Farnsworth, N.R. J. Parm. Sci. 66,600-602 (1977).
• 10. Breton Funes, J.L., Marrero, B.G. and Gonzalez, A.G.An. Quim. 64,187-192 (1968).
• 11. Herz, W. and Sudarsanam, V. Pllytochemistry 9,895-896 (1970).