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The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice

Yıl 2023, , 199 - 210, 30.08.2023

Ayşe Karatuğ Kaçar , Onur Ertik , Zeynep Mine Coşkun , Sema Bolkent , Refiye Yanardağ , Şehnaz Bolkent

https://doi.org/10.26650/IstanbulJPharm.2023.1005935

Öz

Background and Aims: The aim of this study was to investigate the histological and biochemical effects of the antioxidant combination on liver tissue of streptozotocin (STZ)-induced diabetic mice.
Methods: Five groups of mice were given a citrate buffer (CB), the antioxidant solvents (AS), the antioxidant combination (A) (α-lipoic acid, selenium, and vitamin E), STZ (D), the antioxidant combination and STZ (A+D). The mice were sacrificed, and their liver tissues were taken out. The liver tissues were examined histologically and immune+ cell numbers of cannabinoid receptors (CB1R and CB2R) were detected. Xanthine oxidase (XO) activity, glutathione (GSH) and lipid peroxidation (LPO) levels, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), γ-glutamyl transferase (GGT), paraoxonase (PON), glucose-6-phosphate dehydrogenase (G6PD) activities, protein carbonyl content (PCC) and advanced oxidation protein product (AOPP), sialic acid, fucose, hexose and hydroxyproline (OH-proline) levels were biochemically determined.
Results: Certain degenerative changes were reduced in the A+D group compared histologically to the D group. There were no significant changes in the number of CB1R immune+ cells. The number of CB2R immune+ cells was significantly reduced in the D group compared to the CB group. The GSH level, CAT, SOD, GR, GPx, GST, PON, and G6PD activities were increased while XO and GGT activity, LPO, PCC, AOPP, hexose, fucose, sialic acid, and OH-proline level were biochemically decreased in the A+D group compared to the D group.
Conclusion: The use of the antioxidant combination had a positive effect on the livers of diabetic mice with histochemical and biochemical changes, while there was no effect on the regulation of cannabinoid receptors expressions.

Anahtar Kelimeler

Diabetes α-Lipoic Acid Vitamin E Selenium Liver Mouse

Destekleyen Kurum

İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi

Proje Numarası

T-891 ve BEK-2017-24663.

Teşekkür

This study was supported by the Research Fund of Istanbul University. Project Numbers T-891 and BEK-2017-24663.

Kaynakça

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Yıl 2023, , 199 - 210, 30.08.2023

Ayşe Karatuğ Kaçar , Onur Ertik , Zeynep Mine Coşkun , Sema Bolkent , Refiye Yanardağ , Şehnaz Bolkent

https://doi.org/10.26650/IstanbulJPharm.2023.1005935

Öz

Proje Numarası

T-891 ve BEK-2017-24663.

Kaynakça

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Toplam 91 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Article
Yazarlar

Ayşe Karatuğ Kaçar 0000-0001-6032-470X

Onur Ertik 0000-0002-9686-8634

Zeynep Mine Coşkun 0000-0003-4791-6537

Sema Bolkent 0000-0001-8463-5561

Refiye Yanardağ 0000-0003-4185-4363

Şehnaz Bolkent 0000-0002-1112-5162

Proje Numarası T-891 ve BEK-2017-24663.
Yayımlanma Tarihi 30 Ağustos 2023
Gönderilme Tarihi 7 Ekim 2021
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

APA Karatuğ Kaçar, A., Ertik, O., Coşkun, Z. M., Bolkent, S., vd. (2023). The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. İstanbul Journal of Pharmacy, 53(2), 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935
AMA Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. Ağustos 2023;53(2):199-210. doi:10.26650/IstanbulJPharm.2023.1005935
Chicago Karatuğ Kaçar, Ayşe, Onur Ertik, Zeynep Mine Coşkun, Sema Bolkent, Refiye Yanardağ, ve Şehnaz Bolkent. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy 53, sy. 2 (Ağustos 2023): 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935.
EndNote Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş (01 Ağustos 2023) The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. İstanbul Journal of Pharmacy 53 2 199–210.
IEEE A. Karatuğ Kaçar, O. Ertik, Z. M. Coşkun, S. Bolkent, R. Yanardağ, ve Ş. Bolkent, “The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice”, iujp, c. 53, sy. 2, ss. 199–210, 2023, doi: 10.26650/IstanbulJPharm.2023.1005935.
ISNAD Karatuğ Kaçar, Ayşe vd. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy 53/2 (Ağustos 2023), 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935.
JAMA Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. 2023;53:199–210.
MLA Karatuğ Kaçar, Ayşe vd. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy, c. 53, sy. 2, 2023, ss. 199-10, doi:10.26650/IstanbulJPharm.2023.1005935.
Vancouver Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. 2023;53(2):199-210.