Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals

Year 2022, , 215 - 225, 30.08.2022

Bıta Entezarı , Deniz Bozdağ Hande Gürer-orhan

https://doi.org/10.26650/IstanbulJPharm.2022.1027027

Abstract

The incidence of obesity and related diseases increased dramatically in the last decade. Some endocrine disruptors were shown to interact with metabolic processes via various cellular mechanisms, disrupt homeostasis in adipose tissue, resulting in weight gain and obesity. These chemicals are called “obesogens”. Today, with the increased use of industrial chemicals, individuals are exposed to a mixture of chemicals at very low doses. Most of these industrial chemicals have been investigated for their possible endocrine disrupting and obesogenic effects. Beside these chemicals, pharmaceuticals can also have similar adverse effects, however, limited studies have been performed to investigate such effects of drugs. Furthermore, there are few studies investigating the relationship between prenatal exposure to pharmaceuticals and childhood obesity. Therefore, to clarify the endocrine disrupting and obesogenic effects of the pharmaceuticals, which are prescribed during pregnancy, mechanistic studies should be performed, and necessary precautions should be taken. In this paper, we reviewed the mechanisms of obesogens, briefly overview several well-known obesogenic industrial chemicals and focused more on potential obesogenic pharmaceuticals.

Keywords

Endocrine disruptors, Obesogens, Adipogenesis, Lipogenesis, Pharmaceuticals

Supporting Institution

EGE ÜNİVERSİTESİ BAP Koordinatörlüğü

Project Number

TDK-2020-21680

Thanks

Authors are thankful to Ege University Scientific Research Projects Coordination for supporting doctoral research of Bita ENTEZARI with the grant ID # TDK-2020-21680

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