Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Abstract

Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

Keywords

• Sambucus ebulus L.
• in-situ gel
• gelling system
• topical antifungal

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