Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation

Burcin Alev Tuzuner; Esin Ak; Şehkar Oktay; Ünsal Veli Üstündağ; Hazal İpekçi; Ebru Emekli; Tuğba Tunalı Akbay; Şule Çetinel; Göksel Şener; Aysen Yarat; Leyla Alev

doi:10.26650/IstanbulJPharm.2026.1624711

Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation

Abstract

Background and Aims: Myrtus communis L. (MC) is a plant with therapeutic properties on various tissues. In individuals with liver disease and hepatic failure, there is a risk of developing progressive kidney failure. This underscores the critical importance of monitoring and managing these patients' liver and kidney health. The bile duct ligation (BDL) model enables rapid study of renal function changes. This study aimed to identify the potential protective and reversible effects of MC leaf extract on the kidneys of rats.

Methods: The rats were divided into the control group (C), C+MC group, BDL group, and BDL+MC group. After sacrifice, kidney samples were examined through several biochemical analyses. Haematoxylin and eosin staining was used for light microscopic investigations.

Results: In the BDL group, increased lipid peroxidation levels, myeloperoxidase, and tissue factor activities were found, whereas decreased glutathione levels, catalase, and superoxide dismutase activities were found compared to the C and C+MC groups. In addition, increased sialic acid levels were detected in the BDL group compared to the C group. MC extract significantly reversed these changes compared to the BDL group. The biochemical results supported the histological findings.

Conclusion: The beneficial effects of MC on kidney tissue may be due to recovered liver function or its direct action on it. MC may be a promising candidate for further investigation in the treatment and prevention of BDL-induced renal injury.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Biochemistry

Journal Section

Research Article

Authors

Burcin Alev Tuzuner
0000-0001-5122-4977
Türkiye

Esin Ak
0000-0002-3467-7808
Türkiye

Şehkar Oktay ^*
0000-0002-2878-288X
Türkiye

Ünsal Veli Üstündağ
0000-0003-0804-1475
Türkiye

Hazal İpekçi
0000-0003-1193-168X
Türkiye

Ebru Emekli
0000-0003-2419-8587
Türkiye

Tuğba Tunalı Akbay
0000-0002-2091-9298
Türkiye

Şule Çetinel
0000-0003-1912-3679
Türkiye

Göksel Şener
0000-0001-7444-6193
Türkiye

Aysen Yarat
0000-0002-8258-6118
Türkiye

Leyla Alev
0009-0002-9221-2379
Türkiye

Publication Date

May 21, 2026

Submission Date

January 31, 2025

Acceptance Date

December 16, 2025

Published in Issue

Year 2026 Volume: 56 Number: 1

DOI

https://doi.org/10.26650/IstanbulJPharm.2026.1624711

IZ

https://izlik.org/JA83XC98PB

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RIS / Bibtex

APA

Alev Tuzuner, B., Ak, E., Oktay, Ş., Üstündağ, Ü. V., İpekçi, H., Emekli, E., Tunalı Akbay, T., Çetinel, Ş., Şener, G., Yarat, A., & Alev, L. (2026). Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation. İstanbul Journal of Pharmacy, 56(1), 53-61. https://doi.org/10.26650/IstanbulJPharm.2026.1624711

AMA

1.Alev Tuzuner B, Ak E, Oktay Ş, et al. Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation. iujp. 2026;56(1):53-61. doi:10.26650/IstanbulJPharm.2026.1624711

Chicago

Alev Tuzuner, Burcin, Esin Ak, Şehkar Oktay, et al. 2026. “Renal Injury Reversed by Myrtus Communis L. Extract Administration in Rats With Bile Duct Ligation”. İstanbul Journal of Pharmacy 56 (1): 53-61. https://doi.org/10.26650/IstanbulJPharm.2026.1624711.

EndNote

Alev Tuzuner B, Ak E, Oktay Ş, Üstündağ ÜV, İpekçi H, Emekli E, Tunalı Akbay T, Çetinel Ş, Şener G, Yarat A, Alev L (May 1, 2026) Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation. İstanbul Journal of Pharmacy 56 1 53–61.

IEEE

[1]B. Alev Tuzuner et al., “Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation”, iujp, vol. 56, no. 1, pp. 53–61, May 2026, doi: 10.26650/IstanbulJPharm.2026.1624711.

ISNAD

Alev Tuzuner, Burcin - Ak, Esin - Oktay, Şehkar - Üstündağ, Ünsal Veli - İpekçi, Hazal - Emekli, Ebru - Tunalı Akbay, Tuğba et al. “Renal Injury Reversed by Myrtus Communis L. Extract Administration in Rats With Bile Duct Ligation”. İstanbul Journal of Pharmacy 56/1 (May 1, 2026): 53-61. https://doi.org/10.26650/IstanbulJPharm.2026.1624711.

JAMA

1.Alev Tuzuner B, Ak E, Oktay Ş, Üstündağ ÜV, İpekçi H, Emekli E, Tunalı Akbay T, Çetinel Ş, Şener G, Yarat A, Alev L. Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation. iujp. 2026;56:53–61.

MLA

Alev Tuzuner, Burcin, et al. “Renal Injury Reversed by Myrtus Communis L. Extract Administration in Rats With Bile Duct Ligation”. İstanbul Journal of Pharmacy, vol. 56, no. 1, May 2026, pp. 53-61, doi:10.26650/IstanbulJPharm.2026.1624711.

Vancouver

1.Burcin Alev Tuzuner, Esin Ak, Şehkar Oktay, Ünsal Veli Üstündağ, Hazal İpekçi, Ebru Emekli, Tuğba Tunalı Akbay, Şule Çetinel, Göksel Şener, Aysen Yarat, Leyla Alev. Renal Injury Reversed by Myrtus communis L. Extract Administration in Rats with Bile Duct Ligation. iujp. 2026 May 1;56(1):53-61. doi:10.26650/IstanbulJPharm.2026.1624711