Toxicological Evaluation of Siloxanes by In Silico Approaches

Sezen Yılmaz Sarıaltın; Can Özgür Yalçın

doi:10.26650/IstanbulJPharm.2025.1628403

Toxicological Evaluation of Siloxanes by In Silico Approaches

Abstract

Background and Aims: Silicones are widely used in household items, personal care products, and medical devices. They are especially preferred for products used directly on humans, as they are biocompatible, biologically stable, and unlikely to cause allergic reactions. It has been estimated that the global produc tion capacity of siloxanes has reached 400,000 tons annually. Humans in all age groups are exposed to siloxanes from various products by oral, inhalation, dermal, or parenteral routes. For many years, siloxanes have been widely regarded as nontoxic substances, fostering a sense of safety in their use across various applications. However, emerging scientific research reveals a more nuanced perspective, indicating that this assumption of safety cannot be uniformly applied to all siloxanes. This study aimed to evaluate the in silico toxicological profile of sixteen different siloxanes, commonly regarded as safe, thereby questioning their potential risks and the validity of the current safety perception. Methods: This study employed in silico toxicological evaluation of sixteen cyclic and linear siloxanes using VEGA (v.1.2.3), VEGA NRMEA (v.1.1.1), US EPA TEST (v.5.1.2 and 4.2.1), US EPA CompTox Chemicals Dashboard (v.2.5.3), PanScreen, ProTox (v.3.0), and DeepPK models. Results: Our results suggested that siloxanes may affect the endocrine system through the oestrogen receptor (ER) pathway. Conclusion: There is a growing need for new toxicity models that focus on silicone compounds. As our understanding advances, it becomes evident that the diverse chemical structures and behaviours of these compounds may pose potential risks that were previously overlooked.

Keywords

References

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Details

Primary Language

English

Subjects

Toxicology

Journal Section

Research Article

Authors

Sezen Yılmaz Sarıaltın
0000-0002-8387-4146
Türkiye

Can Özgür Yalçın ^*
0000-0003-4032-3229
Türkiye

Publication Date

September 23, 2025

Submission Date

January 31, 2025

Acceptance Date

May 21, 2025

Published in Issue

Year 2025 Volume: 55 Number: 2

DOI

https://doi.org/10.26650/IstanbulJPharm.2025.1628403

IZ

https://izlik.org/JA99JH32PH

Cite

RIS / Bibtex

APA

Yılmaz Sarıaltın, S., & Yalçın, C. Ö. (2025). Toxicological Evaluation of Siloxanes by In Silico Approaches. İstanbul Journal of Pharmacy, 55(2), 233-244. https://doi.org/10.26650/IstanbulJPharm.2025.1628403

AMA

1.Yılmaz Sarıaltın S, Yalçın CÖ. Toxicological Evaluation of Siloxanes by In Silico Approaches. iujp. 2025;55(2):233-244. doi:10.26650/IstanbulJPharm.2025.1628403

Chicago

Yılmaz Sarıaltın, Sezen, and Can Özgür Yalçın. 2025. “Toxicological Evaluation of Siloxanes by In Silico Approaches”. İstanbul Journal of Pharmacy 55 (2): 233-44. https://doi.org/10.26650/IstanbulJPharm.2025.1628403.

EndNote

Yılmaz Sarıaltın S, Yalçın CÖ (September 1, 2025) Toxicological Evaluation of Siloxanes by In Silico Approaches. İstanbul Journal of Pharmacy 55 2 233–244.

IEEE

[1]S. Yılmaz Sarıaltın and C. Ö. Yalçın, “Toxicological Evaluation of Siloxanes by In Silico Approaches”, iujp, vol. 55, no. 2, pp. 233–244, Sept. 2025, doi: 10.26650/IstanbulJPharm.2025.1628403.

ISNAD

Yılmaz Sarıaltın, Sezen - Yalçın, Can Özgür. “Toxicological Evaluation of Siloxanes by In Silico Approaches”. İstanbul Journal of Pharmacy 55/2 (September 1, 2025): 233-244. https://doi.org/10.26650/IstanbulJPharm.2025.1628403.

JAMA

1.Yılmaz Sarıaltın S, Yalçın CÖ. Toxicological Evaluation of Siloxanes by In Silico Approaches. iujp. 2025;55:233–244.

MLA

Yılmaz Sarıaltın, Sezen, and Can Özgür Yalçın. “Toxicological Evaluation of Siloxanes by In Silico Approaches”. İstanbul Journal of Pharmacy, vol. 55, no. 2, Sept. 2025, pp. 233-44, doi:10.26650/IstanbulJPharm.2025.1628403.

Vancouver

1.Sezen Yılmaz Sarıaltın, Can Özgür Yalçın. Toxicological Evaluation of Siloxanes by In Silico Approaches. iujp. 2025 Sep. 1;55(2):233-44. doi:10.26650/IstanbulJPharm.2025.1628403