Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives

Oruç Yunusoğlu; İrem Kalfa; Esma Koyuncu

doi:10.26650/IstanbulJPharm.2026.1689025

Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives

Abstract

The beneficial effects of natural plant polyphenols on human health have been extensively evaluated in numerous scientific studies. Oleuropein, a phenolic compound and ester of elenolic acid and hydroxytyrosol (3,4-dihydroxyphenylethanol), is present in various parts of the olive tree (Olea europaea L.) and has garnered significant scientific interest due to its broad therapeutic profile. An updated and comprehensive review of the existing literature was conducted using databases such as Scopus, PubMed/MEDLINE, Embase, ScienceDirect, SciELO, and SciVerse, without temporal restrictions. This review highlights recent advancements in the therapeutic potential, biological activities, and pharmacological properties of oleuropein, with emphasis on its antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, antiallergic, anti-osteoporotic, anti-ageing, immunomodulatory, anti-obesity, anti-atherosclerotic, cardioprotective, hepatoprotective, nephroprotective, neuroprotective, anti-Alzheimer, antiepileptic, anti- Parkinson, anxiolytic, reproductive, gastrointestinal, respiratory, and endocrine systems. Although oleuropein is utilised as a dietary supplement in various pharmaceutical forms (e.g., tablets, capsules) for certain health conditions, no formulation has yet received regulatory approval from the European Medicines Agency or the United States Food and Drug Administration for the prevention or treatment of diseases. Ongoing comprehensive investigations continue to expand the understanding of oleuropein’s pharmacological properties, therapeutic potential, and biochemical activities. Based on the current findings, oleuropein represents a promising therapeutic agent for the prevention and treatment of various systemic diseases. However, its specific effects and underlying mechanisms in distinct pathological conditions require further validation through future preclinical and clinical studies.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy, Pharmaceutical Botany

Journal Section

Review

Authors

Oruç Yunusoğlu ^*
0000-0003-1075-9574
Türkiye

İrem Kalfa
0009-0002-5658-1011
Türkiye

Esma Koyuncu
0009-0007-5070-4187
Türkiye

Publication Date

May 21, 2026

Submission Date

May 1, 2025

Acceptance Date

January 20, 2026

Published in Issue

Year 2026 Volume: 56 Number: 1

DOI

https://doi.org/10.26650/IstanbulJPharm.2026.1689025

IZ

https://izlik.org/JA46XC39TJ

Cite

RIS / Bibtex

APA

Yunusoğlu, O., Kalfa, İ., & Koyuncu, E. (2026). Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives. İstanbul Journal of Pharmacy, 56(1), 80-104. https://doi.org/10.26650/IstanbulJPharm.2026.1689025

AMA

1.Yunusoğlu O, Kalfa İ, Koyuncu E. Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives. iujp. 2026;56(1):80-104. doi:10.26650/IstanbulJPharm.2026.1689025

Chicago

Yunusoğlu, Oruç, İrem Kalfa, and Esma Koyuncu. 2026. “Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives”. İstanbul Journal of Pharmacy 56 (1): 80-104. https://doi.org/10.26650/IstanbulJPharm.2026.1689025.

EndNote

Yunusoğlu O, Kalfa İ, Koyuncu E (May 1, 2026) Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives. İstanbul Journal of Pharmacy 56 1 80–104.

IEEE

[1]O. Yunusoğlu, İ. Kalfa, and E. Koyuncu, “Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives”, iujp, vol. 56, no. 1, pp. 80–104, May 2026, doi: 10.26650/IstanbulJPharm.2026.1689025.

ISNAD

Yunusoğlu, Oruç - Kalfa, İrem - Koyuncu, Esma. “Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives”. İstanbul Journal of Pharmacy 56/1 (May 1, 2026): 80-104. https://doi.org/10.26650/IstanbulJPharm.2026.1689025.

JAMA

1.Yunusoğlu O, Kalfa İ, Koyuncu E. Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives. iujp. 2026;56:80–104.

MLA

Yunusoğlu, Oruç, et al. “Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives”. İstanbul Journal of Pharmacy, vol. 56, no. 1, May 2026, pp. 80-104, doi:10.26650/IstanbulJPharm.2026.1689025.

Vancouver

1.Oruç Yunusoğlu, İrem Kalfa, Esma Koyuncu. Comprehensive Analysis of Oleuropein: Current Evidence on Pharmacological Activities, Therapeutic Applications and Translational Perspectives. iujp. 2026 May 1;56(1):80-104. doi:10.26650/IstanbulJPharm.2026.1689025