The development and in vitro evaluation of benzydamine hydrochloride medicated chewing gum formulations

Yıl 2017, , 45 - 51, 18.10.2017

Özlem Akbal Erdal Cevher Ahmet Oğul Araman

https://doi.org/10.5152/IstanbulJPharm.2017.007

Öz

The objective of this study was to develop
a chewing gum formulation for benzydamine hydrochloride (BN) and evaluate the
effect of different co-compression agents on physicochemical parameters and in
vitro drug release profile. BN has been utilized in symptomatic treatment  for pain and irritations of the mouth and
throat. Chewing gum formulations of BN were produced using direct compression
method. In fabricated chewing gums, except pharmacopeia analysis, physical and
structural analysis like thickness, weight variation, elasticity and
compressibility were evaluated. The release of BN from the gum was studied
using the chewing apparatus which have been designed for procuring the release
of BN from the chewing gum.The quantity of BN present in the chewing gum and
the release medium were quantified by spectrophotometric method. Gum formulations
showed promising in vitro release profiles, in which 80–90% BN was released in
a sustained manner over 20 min of chewing time. In addition, it was observed
that the drug release was fitted into matrix diffusion kinetic and revealed a
non-Fickian drug release mechanism. This study suggests that BN in a gum
formulation  is a suitable dosage form
for the delivery in the oral cavity, thereby and serving as an instant
analgesic.

Anahtar Kelimeler

Benzydamine hydrochloride, medicated chewing gum, mastication apparatus

Kaynakça

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