Araştırma Makalesi
BibTex RIS Kaynak Göster

Yıl 2021, , 333 - 340, 29.12.2021

Aparna Ann Mathew , Raju Asirvatham , A Gowtham Daisy Pa

https://doi.org/10.26650/IstanbulJPharm.2021.877929

Öz

Kaynakça

  • Arya, V., & Guota, V. K. (2011). Review on some cardioprotective plants from Ayurveda. International Journal of Research in Ayurveda and Pharmacy, 2(1), 80-83.
  • • Bag, G. C., Devi, P. G., & Bhaigyabati, T. H. (2015). Assessment of total flavonoid content and antioxidant activity of methanolic rhizome extract of three Hedychium species of Manipur valley. International Journal of Pharmaceutical Sciences Review and Research, 30(1), 154-159.
  • • Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammationassociated diseases in organs. Oncotarget, 9, 7204-7218. https:// doi.org/10.18632/oncotarget.23208
  • • Fan, W., Sun, L., Zhou, J. Q., Zhang, C., Qin, S., Tang, Y., Liu, Y., Lin, S. S., & Yuan, S. T. (2015). Marsdenia tenacissima extract induces G0/ G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway. Chinese journal of natural medicines, 13(6), 428–437. https:// doi.org/10.1016/S1875-5364(15)30036-4
  • • Galhena, P. B., Samarakoon, S. R., Thabrew, M. I., Weerasinghe, G. A., Thammitiyagodage, M. G., Ratnasooriya, W. D., & Tennekoon, K. H. (2012). Anti-Inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) mediates its antihepatocarcinogenic effects. Evidence-based complementary and alternative medicine: eCAM, 2012, 108626. https:// doi.org/10.1155/2012/108626
  • • Gogtay, N. J., Bhatt, H. A., Dalvi, S. S., & Kshirsagar, N. A. (2002). The use and safety of non-allopathic Indian medicines. Drug safety, 25(14), 1005–1019. https://doi.org/10.2165/00002018- 200225140-0000
  • • Gul, R., Jan, S.U., Faridullah, S., Sherani, S., & Jahan, N. (2017). Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from Ephedra intermedia indigenous to Balochistan. The Scientific World Journal, 2017. https://doi.org/10.1155/2017/5873648
  • • Haldar, P. K., Kar, B., Bala, A., Bhattacharya, S., & Mazumder, U. K. (2010). Antitumor activity of Sansevieria roxburghiana rhizome against Ehrlich ascites carcinoma in mice. Pharmaceutical biology, 48(12), 1337–1343. https://doi.org/10.3109/13880201003792592
  • • Hatapakki. B. C., & Hukkeri, V. I. (2011). Antipyretic activity of root of Marsdenia tenacissima in rats. Journal of Natural Remedies, 11(2), 98-102. https://doi.org/10.18311/jnr/2011/433
  • • Hepsibah, A. H., & Jothi, G. J. (2017). A comparative study on the effect of solvents on the phytochemical profile and biological potential of Ormocarpum cochinchinense Auct. Non (Lour.) Merrill. International Journal of Pharmacy and Pharmaceutical Sciences, 9(1), 67-72. https://doi.org/10.22159/ijpps.2017v9i1.15126
  • • Heroor, S., Beknal, A. K., & Mahurkar, N. (2013). Immunomodulatory activity of methanolic extracts of fruits and bark of Ficus glomerata Roxb. in mice and on human neutrophils. Indian Journal of Pharmacology, 45(2), 130-135.
  • • Huang, C. F., Lin, S. S., Liao, P. H., Young, S. C., & Yang, C. C. (2008). The immunopharmaceutical effects and mechanisms of herb medicine. Cellular & Molecular Immunology, 5(1), 23-31. https:// doi.org/10.1038/cmi.2008.3.
  • • Huang, M. Y., Zhang, L. L., Ding, J., & Lu, J. J. (2018). Anticancer drug discovery from Chinese medicinal herbs. Chinese medicine, 13(1), 1-9. https://doi.org/10.1186/s13020-018-0192-y
  • • Lokhande P D, Jagdale S C, Chabukswar A R (2006). Natural remedies for heart diseases. Indian Journal of Traditional Knowledge, 5(3), 420-427.
  • • Mathew, A. A., Asirvatham, R., & Tomy, D. V. (2021). Cardioprotective Effect of Marsdenia tenacissima and Sansevieria roxburghiana in Doxorubicin-induced Cardiotoxicity in Rats in vivo: The Role of Dresgenin and Lupeol. Turkish journal of pharmaceutical sciences, 18(3), 271–281. https://doi.org/10.4274/tjps.galenos.2020.27880
  • • Muñoz, M., Cedeño, R., Rodrìguez, J., Vander, Knaap, W.P., Mialhe. E., & Bachère, E. (2000). Measurement of reactive oxygen intermediate production in haemocytes of the penaeid shrimp, Penaeus vannamei. Aquaculture, 191, 89–107.
  • • Obydulla, O. (2016). Sansevieria roxburghiana Schult. & Schult. F., Agavaceae: phytochemistry, traditional uses and its pharmacological activities-a review. World scientific new, 59, 24-34.
  • • Prabhakar, U., Brooks, D. P., Lipshlitz, D., & Esser, K. M. (1995). Inhibition of LPS- induced TNF alpha production in human monocytes by adenosine (A2) receptor selective agonists. International journal of immunopharmacology, 17(3), 221–224. https://doi. org/10.1016/0192-0561(94)00096-7
  • • Raju, A., Seeja, S. R., Deshami, S. S., Sinchu, Y., & Malu, P. (2015). Cell membrane stabilizing effect of ethanol and aqueous extract of Humboldtia vahliana Wight an in vitro study. Spatula DD, 5(3), 171-175.
  • • Sakthivel, K. M., & Guruvayoorappan, C. (2013). Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators-( TNF-a, iNOS, COX-2, IL-1β, IL-6, IFN-γ, IL-2, GM-CSF) and pro-angiogenic growth factor- VEGF. Asian Pacific journal of cancer prevention: APJCP, 14(6), 3909–3919. https://doi.org/10.7314/ apjcp.2013.14.6.3909
  • • da Silva, A. P., Nascimento da Silva, L. C., Martins da Fonseca, C. S., de Araújo, J. M., Correia, M. T., Cavalcanti, M., & Lima, V. L. (2016). Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc. Frontiers in microbiology, 7, 963. https://doi.org/10.3389/fmicb.2016.00963
  • • Tiwari, V., Singh, A., & Tiwari, A. (2018). Phytopharmacological overview on controversial drug: Murva. Traditional and Folk Herbal Medicine: Recent Researches, 2, 475-526.
  • • Trease, G. E., & Evans, W. C. (1989). Pharmacognosy. 13th (ed). ELBS/Bailliere Tindall, London. Pp.345-346, 535-536, 772-773.
  • • Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., & Deshpande, M. (2010) Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative • disorders: ashwagandha. Central Nervous System Agents in Medicinal Chemistry, 10(3), 238-246.
  • • Yamada, Y., Webber, E. M., Kirillova, I., Peschon, J. J., & Fausto, N. (1998). Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor. Hepatology (Baltimore, Md.), 28(4), 959–970. https://doi.org/10.1002/hep.510280410

Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva

Yıl 2021, , 333 - 340, 29.12.2021

Aparna Ann Mathew , Raju Asirvatham , A Gowtham Daisy Pa

https://doi.org/10.26650/IstanbulJPharm.2021.877929

Öz

Background and Aims: Toxic chemicals, pathogens and damaged cells trigger the inflammatory process and cause disease in the kidney, heart, brain, liver, lung and reproductive system. The present study evaluates the anti-inflammatory and immunomodulatory effect of Ayurvedic plants under the Murva category. Methods: Marsdenia tenacissima is an acceptable source of Murva. Sansevieria roxburghiana is considered as Murva in west Bengal. Methanol extracts of both plants were used to evaluate anti-inflammatory and immunomodulatory effects by certain in vitro methods. The in vitro anti-inflammatory effects of methanol extract Marsdenia tenacissima (MEMT) and methanol extract of Sansevieria roxburghiana (MESR) were assessed by heat and hypotonic induced haemolysis on the red blood cells of rats. Nitro blue tetrazolium (NBT) assay and inhibition of TNF-α release in DAL cell lines were conducted to assess the immunomodulatory potential of extracts. Results: MEMT, MESR and a combination of MEMT&MESR showed significant (p<0.001) inhibition of haemolysis on heat and hypotonic induced methods compared with the standard Diclofenac Sodium. In NBT reduction test, MEMT showed a more significant (p<0.001) result than MESR. Similarly, the inhibition of TNF-α release was also significantly enhanced by 400 μg/ mL of MEMT. Conclusion: The present research results revealed that Murva is a safe Ayurveda drug for the treatment of cancer and cardiac disease with the protection of systemic immunity and set free from an inflammatory condition.

Anahtar Kelimeler

Murva Marsdenia tenacissima Sansevieria roxburghiana in vitro anti-inflammatory immunomodulatory NBT assay

Teşekkür

The authors gratefully thanks to Director Dr. Sr. Betty Carla from St. Joseph’s College of Pharmacy, Cherthala, Kerala for providing support and facilities for this research work.

Kaynakça

  • Arya, V., & Guota, V. K. (2011). Review on some cardioprotective plants from Ayurveda. International Journal of Research in Ayurveda and Pharmacy, 2(1), 80-83.
  • • Bag, G. C., Devi, P. G., & Bhaigyabati, T. H. (2015). Assessment of total flavonoid content and antioxidant activity of methanolic rhizome extract of three Hedychium species of Manipur valley. International Journal of Pharmaceutical Sciences Review and Research, 30(1), 154-159.
  • • Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammationassociated diseases in organs. Oncotarget, 9, 7204-7218. https:// doi.org/10.18632/oncotarget.23208
  • • Fan, W., Sun, L., Zhou, J. Q., Zhang, C., Qin, S., Tang, Y., Liu, Y., Lin, S. S., & Yuan, S. T. (2015). Marsdenia tenacissima extract induces G0/ G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway. Chinese journal of natural medicines, 13(6), 428–437. https:// doi.org/10.1016/S1875-5364(15)30036-4
  • • Galhena, P. B., Samarakoon, S. R., Thabrew, M. I., Weerasinghe, G. A., Thammitiyagodage, M. G., Ratnasooriya, W. D., & Tennekoon, K. H. (2012). Anti-Inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) mediates its antihepatocarcinogenic effects. Evidence-based complementary and alternative medicine: eCAM, 2012, 108626. https:// doi.org/10.1155/2012/108626
  • • Gogtay, N. J., Bhatt, H. A., Dalvi, S. S., & Kshirsagar, N. A. (2002). The use and safety of non-allopathic Indian medicines. Drug safety, 25(14), 1005–1019. https://doi.org/10.2165/00002018- 200225140-0000
  • • Gul, R., Jan, S.U., Faridullah, S., Sherani, S., & Jahan, N. (2017). Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from Ephedra intermedia indigenous to Balochistan. The Scientific World Journal, 2017. https://doi.org/10.1155/2017/5873648
  • • Haldar, P. K., Kar, B., Bala, A., Bhattacharya, S., & Mazumder, U. K. (2010). Antitumor activity of Sansevieria roxburghiana rhizome against Ehrlich ascites carcinoma in mice. Pharmaceutical biology, 48(12), 1337–1343. https://doi.org/10.3109/13880201003792592
  • • Hatapakki. B. C., & Hukkeri, V. I. (2011). Antipyretic activity of root of Marsdenia tenacissima in rats. Journal of Natural Remedies, 11(2), 98-102. https://doi.org/10.18311/jnr/2011/433
  • • Hepsibah, A. H., & Jothi, G. J. (2017). A comparative study on the effect of solvents on the phytochemical profile and biological potential of Ormocarpum cochinchinense Auct. Non (Lour.) Merrill. International Journal of Pharmacy and Pharmaceutical Sciences, 9(1), 67-72. https://doi.org/10.22159/ijpps.2017v9i1.15126
  • • Heroor, S., Beknal, A. K., & Mahurkar, N. (2013). Immunomodulatory activity of methanolic extracts of fruits and bark of Ficus glomerata Roxb. in mice and on human neutrophils. Indian Journal of Pharmacology, 45(2), 130-135.
  • • Huang, C. F., Lin, S. S., Liao, P. H., Young, S. C., & Yang, C. C. (2008). The immunopharmaceutical effects and mechanisms of herb medicine. Cellular & Molecular Immunology, 5(1), 23-31. https:// doi.org/10.1038/cmi.2008.3.
  • • Huang, M. Y., Zhang, L. L., Ding, J., & Lu, J. J. (2018). Anticancer drug discovery from Chinese medicinal herbs. Chinese medicine, 13(1), 1-9. https://doi.org/10.1186/s13020-018-0192-y
  • • Lokhande P D, Jagdale S C, Chabukswar A R (2006). Natural remedies for heart diseases. Indian Journal of Traditional Knowledge, 5(3), 420-427.
  • • Mathew, A. A., Asirvatham, R., & Tomy, D. V. (2021). Cardioprotective Effect of Marsdenia tenacissima and Sansevieria roxburghiana in Doxorubicin-induced Cardiotoxicity in Rats in vivo: The Role of Dresgenin and Lupeol. Turkish journal of pharmaceutical sciences, 18(3), 271–281. https://doi.org/10.4274/tjps.galenos.2020.27880
  • • Muñoz, M., Cedeño, R., Rodrìguez, J., Vander, Knaap, W.P., Mialhe. E., & Bachère, E. (2000). Measurement of reactive oxygen intermediate production in haemocytes of the penaeid shrimp, Penaeus vannamei. Aquaculture, 191, 89–107.
  • • Obydulla, O. (2016). Sansevieria roxburghiana Schult. & Schult. F., Agavaceae: phytochemistry, traditional uses and its pharmacological activities-a review. World scientific new, 59, 24-34.
  • • Prabhakar, U., Brooks, D. P., Lipshlitz, D., & Esser, K. M. (1995). Inhibition of LPS- induced TNF alpha production in human monocytes by adenosine (A2) receptor selective agonists. International journal of immunopharmacology, 17(3), 221–224. https://doi. org/10.1016/0192-0561(94)00096-7
  • • Raju, A., Seeja, S. R., Deshami, S. S., Sinchu, Y., & Malu, P. (2015). Cell membrane stabilizing effect of ethanol and aqueous extract of Humboldtia vahliana Wight an in vitro study. Spatula DD, 5(3), 171-175.
  • • Sakthivel, K. M., & Guruvayoorappan, C. (2013). Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators-( TNF-a, iNOS, COX-2, IL-1β, IL-6, IFN-γ, IL-2, GM-CSF) and pro-angiogenic growth factor- VEGF. Asian Pacific journal of cancer prevention: APJCP, 14(6), 3909–3919. https://doi.org/10.7314/ apjcp.2013.14.6.3909
  • • da Silva, A. P., Nascimento da Silva, L. C., Martins da Fonseca, C. S., de Araújo, J. M., Correia, M. T., Cavalcanti, M., & Lima, V. L. (2016). Antimicrobial Activity and Phytochemical Analysis of Organic Extracts from Cleome spinosa Jaqc. Frontiers in microbiology, 7, 963. https://doi.org/10.3389/fmicb.2016.00963
  • • Tiwari, V., Singh, A., & Tiwari, A. (2018). Phytopharmacological overview on controversial drug: Murva. Traditional and Folk Herbal Medicine: Recent Researches, 2, 475-526.
  • • Trease, G. E., & Evans, W. C. (1989). Pharmacognosy. 13th (ed). ELBS/Bailliere Tindall, London. Pp.345-346, 535-536, 772-773.
  • • Ven Murthy, M. R., Ranjekar, P. K., Ramassamy, C., & Deshpande, M. (2010) Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative • disorders: ashwagandha. Central Nervous System Agents in Medicinal Chemistry, 10(3), 238-246.
  • • Yamada, Y., Webber, E. M., Kirillova, I., Peschon, J. J., & Fausto, N. (1998). Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor. Hepatology (Baltimore, Md.), 28(4), 959–970. https://doi.org/10.1002/hep.510280410
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Original Article
Yazarlar

Aparna Ann Mathew 0000-0001-7197-4644

Raju Asirvatham 0000-0002-7939-4975

A Gowtham Bu kişi benim 0000-0002-8908-0320

Daisy Pa Bu kişi benim 0000-0002-7588-5312

Yayımlanma Tarihi 29 Aralık 2021
Gönderilme Tarihi 18 Şubat 2021
Yayımlandığı Sayı Yıl 2021

Kaynak Göster

APA Ann Mathew, A., Asirvatham, R., Gowtham, A., Pa, D. (2021). Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva. İstanbul Journal of Pharmacy, 51(3), 333-340. https://doi.org/10.26650/IstanbulJPharm.2021.877929
AMA Ann Mathew A, Asirvatham R, Gowtham A, Pa D. Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva. iujp. Aralık 2021;51(3):333-340. doi:10.26650/IstanbulJPharm.2021.877929
Chicago Ann Mathew, Aparna, Raju Asirvatham, A Gowtham, ve Daisy Pa. “Study of in Vitro Antiinflammatory and Immunomodulatory Effect of Ayurvedic Plants – Murva”. İstanbul Journal of Pharmacy 51, sy. 3 (Aralık 2021): 333-40. https://doi.org/10.26650/IstanbulJPharm.2021.877929.
EndNote Ann Mathew A, Asirvatham R, Gowtham A, Pa D (01 Aralık 2021) Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva. İstanbul Journal of Pharmacy 51 3 333–340.
IEEE A. Ann Mathew, R. Asirvatham, A. Gowtham, ve D. Pa, “Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva”, iujp, c. 51, sy. 3, ss. 333–340, 2021, doi: 10.26650/IstanbulJPharm.2021.877929.
ISNAD Ann Mathew, Aparna vd. “Study of in Vitro Antiinflammatory and Immunomodulatory Effect of Ayurvedic Plants – Murva”. İstanbul Journal of Pharmacy 51/3 (Aralık 2021), 333-340. https://doi.org/10.26650/IstanbulJPharm.2021.877929.
JAMA Ann Mathew A, Asirvatham R, Gowtham A, Pa D. Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva. iujp. 2021;51:333–340.
MLA Ann Mathew, Aparna vd. “Study of in Vitro Antiinflammatory and Immunomodulatory Effect of Ayurvedic Plants – Murva”. İstanbul Journal of Pharmacy, c. 51, sy. 3, 2021, ss. 333-40, doi:10.26650/IstanbulJPharm.2021.877929.
Vancouver Ann Mathew A, Asirvatham R, Gowtham A, Pa D. Study of in vitro antiinflammatory and immunomodulatory effect of Ayurvedic plants – Murva. iujp. 2021;51(3):333-40.