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Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant

Yıl 2019, Cilt: 49 Sayı: 2, 45 - 52, 01.08.2019

Öz

DOI: 10.26650/IstanbulJPharm.2019.18001


The aim of this study is to evaluate the
antimicrobial, antioxidant, and antigenotoxic activity of extracts obtained
from Diplotaenia cachrydifolia Boiss, which is traditionally used for food and
medical treatment by the local people of Hakkâri Province (Turkey). As a result
of this study, the extracts of D. cachrydifolia exhibited a broad antimicrobial
spectrum and high antimicrobial activity. It was also observed that the
extracts had a high antioxidant activity. The DPPH IC50 values of the extracts
were 2.5234 µg/mL, 6.0075 µg/mL, and 29.1974 µg/mL for ethanol, acetone, and
hexane, respectively. The highest phenol content was found to be 55.36±0.035
μg/mL for ethanol. Furthermore, the ethanol extract was found to have a
protective effect against mitomycin C-induced genotoxicity. D. cachrydifolia
has a high biological activity; therefore, it is anticipated that future
pharmacological studies will shed more light on this plant. 

Cite this article as: Uğraş S, Ülger S, Göç
Rasgele P (2019). Evaluation of biological activity of Diplotaenia
cachrydifolia Boiss. that medicinal plant. Istanbul J Pharm 49 (2): 45-52.

Kaynakça

  • Agaoglu S, Dostbil N, Alemdar S (2005). The Antibacterial Efficiency Of Some Herbs Used in Herby Cheese. YYÜ Vet Fak Derg 2: 39-41. Amkiss S, Dallouh A, Idaomar M, Amkiss B (2013). Genotoxicity and anti-genotoxicity of fennel plant (Foeniculum vulgare Mill) fruit extracts using the somatic mutation and recombination test (SMART). Afr J Food Sci 7: 193-197. Anokwuru CP, Anyasor GN, Ajibaye O, Fakoya O, Okebugwu P (2011). Effect of extraction solvents on phenolic, flavonoid and antioxidant activities of three Nigerian medicinal plants. Nature and Science 9: 53-61. Arullappan S, Zakaria Z, Basri DF (2009). Preliminary Screening of Antibacterial Activity Using Crude Extracts of Hibiscus Rosa sinensis. Trop Life Sci Res 20: 109-118. Atoui K, Mansouri A, Boskou G, Kefalas P (2005). Tea and Herbal infusions: Their antioksidant activity and phenolic profile. Food Chem 89: 27-36. Azarnivand H, Alikhah Asl M, Arzani H, Amin Gh, Jafari M, Mousavi SS (2009). The variations of oil content and composition of Diplotaenia cachrydifolia Boiss. in green and dry states as a forage anti-quality factor. Iranian Journal of Medicinal and Aromatic Plants 25: 85-91. Baravalia Y, Kaneria M, Vaghaslya Y, Parekh J, Chanda S (2009). Antioxidant and antibacterial activity of Diospyros ebenum roxb. leaf extracts. Turk J Biol 33: 159-164. Berber I, Avsar C, Cin N, Bozkurt N, Elmas E (2013). Determination of Antibacterial and Antifungal Activities of Methanolic Extracts of Some Plants Growing in Sinop. Karaelmas Sci Eng J 3: 10-16. Bhouri W, Derbel S, Skandrani I, Boubaker J, Bouhlel IB, Sghaier M, Kilani SM, Mariotte A, Dijoux-Franca MG, Ghedira K, Chekir-Ghedira L (2010) Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicol In Vitro 24: 509-515. Brand Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. Lebensm Wiss Technol 28: 25-30. Cavlak S, Yagmur C (2016). Determination of Total Phenolic Content and Antioxidant Activities Some Of Tea Bags. CU J Sci Engineering 34: 11-19. Chaabane F, Boubaker J, Loussaif A, Neffati A, Kilani-Jaziri S, Ghedira K, Chekir-Ghedira L (2012). Antioxidant, genotoxic and antigenotoxic activities of Daphne gnidium leaf extracts. BMC Complement Altern Med 12: 153. Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS, Ahmad MA (2014). Comparative Analysis of Total Phenolic and Total Flavonoid Contents, Rutin, Tannins and Antioxidant Capacity in Apiaceae and Lamiaceae families. Indian Horticulture Journal 4: 131-140. Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS (2013). Phenolic profile, antioxidant and antimicrobial activities from the Apiaceae family (dry seeds). MJPMS 2: 26-31. Chung KT, Thomasson WR, Wu-Yuan CD (1990). Growth inhibition of selected food-borne bacteria, particularly Listeria monocytogenes, by plant extracts. J Appl Bacteriol 69: 498-503. Coruh N, Sagdıcoglu Celep AG, Ozgokce F (2007). Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food Chem 100: 1237-1242. Darlington CA, La Cour LE (1979). The Handling of Chromosomes. 6th ed. Allen and Unwin, London, p.201. Demir E, Kaya B, Marcos R, Kocaoğlu Cenkci S, Çetin H (2013). Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay. Turk J Biol 37: 129-138. Döger MM (2010). Antioxidant activity of Trachystemon orientalis (L.) G. Don. Institute of Science, Department of Chemistry, PhD. Thesis, İstanbul University. Eftekhar F, Yousefzadi M, Azizian D, Sonboli A, Salehi P (2005). Essential oil composition and antimicrobial activity of Diplotaenia damavandica. Z Naturforsch C 60: 821-825. Ertürk O, Şahin H, Kolaylı S, Çol Ayvaz M (2014). Antioxidant and antimicrobial activity of East Black Sea Region honeys. Turk J Biochem 39: 99-106. Harkiss KJ, Salehy Surmaghy MH (1988). Diplotaenia cachrydifolia, a new source of jatamansin and jatamansinol. Fitoterapia 59: 55-56. Kada T, Morita K, Inoue T (1978). Antimutagenic action of vegetable factor (s) on the mutagenic principle of tryptophan pyrolysate. Mutat Res 53: 351-353. Karamova NS, Fatykhova DG, Abdrakhimova YR, Il’inskaya ON (2011). An Investigation of Antigenotoxic Properties of Plant Extracts of Chelidonium majus L., Plantago major L. and Tussilago farfara L. Russ J Genet 1: 371-378. Kaval I, Behçet L, Cakilcioglu U (2014). Ethnobotanical study on medicinal plants in Geçitli and its surrounding (Hakkari-Turkey). J Ethnopharmacol 155: 171-184. Khajeh M, Moghaddam MG, Shakeri M (2012). Application of artificial neural network in predicting the extraction yield of essential oils of Diplotaenia cachrydifolia by supercritical fluid extraction. J Supercritical Fluids 69: 91-96. Kilani-Jaziri S, Bhouri W, Skandrani I, Limem I, Chekir-Ghedira L, Ghedira K (2011). Phytochemical, antimicrobial, antioxidant and antigenotoxic potentials of Cyperus rotundus extracts. S Afr J Bot 77: 767-776. Kumari A, Sharma S, Vig AP (2013). Evaluation of anticytogenetic effects of Brassica oleraceae L. Var. Italica in Allium cepa. Int J Pharm Pharm Sci 5: 120-124. Lima DC dS, Vale C Rd, Ve´ras JH, Bernardes A, Pe´rez CN, Chen-Chen L (2017). Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. Plos One 12: 1-15. Mükemre M, Behçet L, Çakılcıoğlu U (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol 166: 361-374. Nogochi C, Nikki E (2000). Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drugs for atherosclerosis. Free Radic Biol Med 28: 1538-1546. Rasool Hassan BA (2012). Medicinal Plants (Importance and Uses). Pharm Anal Acta 3: 139. Rates SMK (2001). Plants as source of drugs. Toxicon 39: 603-613. Sen A, Batra A (2012). Evaluation of antimicrobial activity of different solvent extracts of medicinal plant: Melia Azedarach L. Int J Curr Pharm Res 4: 67–73. Silva DSBS, Barboza B, Garcia ACFS, Oliveira B de Estevam CS, Neto VA, et al. (2013). Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa. Rev Bras Farmacogn 23: 273-278. Sokmen BB, Ugras S, Sarikaya HY, Ugras HI, Yanardag R (2013). Antibacterial, antiurease and antioxidant activities of some Arylidene barbiturates. Appl Biochem Biotechnol 171: 2030-2039. Uce I, Tunçtürk M (2014). Wild Plants which Naturally Grown and Widely Used in Hakkari. Res J Biol Sci 7: 21-25. Young IS, Woodside JV (2001). Antioxidants in health and disease. J Clin Pathol 54: 176-186.
Yıl 2019, Cilt: 49 Sayı: 2, 45 - 52, 01.08.2019

Öz

Kaynakça

  • Agaoglu S, Dostbil N, Alemdar S (2005). The Antibacterial Efficiency Of Some Herbs Used in Herby Cheese. YYÜ Vet Fak Derg 2: 39-41. Amkiss S, Dallouh A, Idaomar M, Amkiss B (2013). Genotoxicity and anti-genotoxicity of fennel plant (Foeniculum vulgare Mill) fruit extracts using the somatic mutation and recombination test (SMART). Afr J Food Sci 7: 193-197. Anokwuru CP, Anyasor GN, Ajibaye O, Fakoya O, Okebugwu P (2011). Effect of extraction solvents on phenolic, flavonoid and antioxidant activities of three Nigerian medicinal plants. Nature and Science 9: 53-61. Arullappan S, Zakaria Z, Basri DF (2009). Preliminary Screening of Antibacterial Activity Using Crude Extracts of Hibiscus Rosa sinensis. Trop Life Sci Res 20: 109-118. Atoui K, Mansouri A, Boskou G, Kefalas P (2005). Tea and Herbal infusions: Their antioksidant activity and phenolic profile. Food Chem 89: 27-36. Azarnivand H, Alikhah Asl M, Arzani H, Amin Gh, Jafari M, Mousavi SS (2009). The variations of oil content and composition of Diplotaenia cachrydifolia Boiss. in green and dry states as a forage anti-quality factor. Iranian Journal of Medicinal and Aromatic Plants 25: 85-91. Baravalia Y, Kaneria M, Vaghaslya Y, Parekh J, Chanda S (2009). Antioxidant and antibacterial activity of Diospyros ebenum roxb. leaf extracts. Turk J Biol 33: 159-164. Berber I, Avsar C, Cin N, Bozkurt N, Elmas E (2013). Determination of Antibacterial and Antifungal Activities of Methanolic Extracts of Some Plants Growing in Sinop. Karaelmas Sci Eng J 3: 10-16. Bhouri W, Derbel S, Skandrani I, Boubaker J, Bouhlel IB, Sghaier M, Kilani SM, Mariotte A, Dijoux-Franca MG, Ghedira K, Chekir-Ghedira L (2010) Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicol In Vitro 24: 509-515. Brand Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. Lebensm Wiss Technol 28: 25-30. Cavlak S, Yagmur C (2016). Determination of Total Phenolic Content and Antioxidant Activities Some Of Tea Bags. CU J Sci Engineering 34: 11-19. Chaabane F, Boubaker J, Loussaif A, Neffati A, Kilani-Jaziri S, Ghedira K, Chekir-Ghedira L (2012). Antioxidant, genotoxic and antigenotoxic activities of Daphne gnidium leaf extracts. BMC Complement Altern Med 12: 153. Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS, Ahmad MA (2014). Comparative Analysis of Total Phenolic and Total Flavonoid Contents, Rutin, Tannins and Antioxidant Capacity in Apiaceae and Lamiaceae families. Indian Horticulture Journal 4: 131-140. Christova-Bagdassarian VL, Bagdassarian KS, Atanassova MS (2013). Phenolic profile, antioxidant and antimicrobial activities from the Apiaceae family (dry seeds). MJPMS 2: 26-31. Chung KT, Thomasson WR, Wu-Yuan CD (1990). Growth inhibition of selected food-borne bacteria, particularly Listeria monocytogenes, by plant extracts. J Appl Bacteriol 69: 498-503. Coruh N, Sagdıcoglu Celep AG, Ozgokce F (2007). Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase. Food Chem 100: 1237-1242. Darlington CA, La Cour LE (1979). The Handling of Chromosomes. 6th ed. Allen and Unwin, London, p.201. Demir E, Kaya B, Marcos R, Kocaoğlu Cenkci S, Çetin H (2013). Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay. Turk J Biol 37: 129-138. Döger MM (2010). Antioxidant activity of Trachystemon orientalis (L.) G. Don. Institute of Science, Department of Chemistry, PhD. Thesis, İstanbul University. Eftekhar F, Yousefzadi M, Azizian D, Sonboli A, Salehi P (2005). Essential oil composition and antimicrobial activity of Diplotaenia damavandica. Z Naturforsch C 60: 821-825. Ertürk O, Şahin H, Kolaylı S, Çol Ayvaz M (2014). Antioxidant and antimicrobial activity of East Black Sea Region honeys. Turk J Biochem 39: 99-106. Harkiss KJ, Salehy Surmaghy MH (1988). Diplotaenia cachrydifolia, a new source of jatamansin and jatamansinol. Fitoterapia 59: 55-56. Kada T, Morita K, Inoue T (1978). Antimutagenic action of vegetable factor (s) on the mutagenic principle of tryptophan pyrolysate. Mutat Res 53: 351-353. Karamova NS, Fatykhova DG, Abdrakhimova YR, Il’inskaya ON (2011). An Investigation of Antigenotoxic Properties of Plant Extracts of Chelidonium majus L., Plantago major L. and Tussilago farfara L. Russ J Genet 1: 371-378. Kaval I, Behçet L, Cakilcioglu U (2014). Ethnobotanical study on medicinal plants in Geçitli and its surrounding (Hakkari-Turkey). J Ethnopharmacol 155: 171-184. Khajeh M, Moghaddam MG, Shakeri M (2012). Application of artificial neural network in predicting the extraction yield of essential oils of Diplotaenia cachrydifolia by supercritical fluid extraction. J Supercritical Fluids 69: 91-96. Kilani-Jaziri S, Bhouri W, Skandrani I, Limem I, Chekir-Ghedira L, Ghedira K (2011). Phytochemical, antimicrobial, antioxidant and antigenotoxic potentials of Cyperus rotundus extracts. S Afr J Bot 77: 767-776. Kumari A, Sharma S, Vig AP (2013). Evaluation of anticytogenetic effects of Brassica oleraceae L. Var. Italica in Allium cepa. Int J Pharm Pharm Sci 5: 120-124. Lima DC dS, Vale C Rd, Ve´ras JH, Bernardes A, Pe´rez CN, Chen-Chen L (2017). Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. Plos One 12: 1-15. Mükemre M, Behçet L, Çakılcıoğlu U (2015). Ethnobotanical study on medicinal plants in villages of Çatak (Van-Turkey). J Ethnopharmacol 166: 361-374. Nogochi C, Nikki E (2000). Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drugs for atherosclerosis. Free Radic Biol Med 28: 1538-1546. Rasool Hassan BA (2012). Medicinal Plants (Importance and Uses). Pharm Anal Acta 3: 139. Rates SMK (2001). Plants as source of drugs. Toxicon 39: 603-613. Sen A, Batra A (2012). Evaluation of antimicrobial activity of different solvent extracts of medicinal plant: Melia Azedarach L. Int J Curr Pharm Res 4: 67–73. Silva DSBS, Barboza B, Garcia ACFS, Oliveira B de Estevam CS, Neto VA, et al. (2013). Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa. Rev Bras Farmacogn 23: 273-278. Sokmen BB, Ugras S, Sarikaya HY, Ugras HI, Yanardag R (2013). Antibacterial, antiurease and antioxidant activities of some Arylidene barbiturates. Appl Biochem Biotechnol 171: 2030-2039. Uce I, Tunçtürk M (2014). Wild Plants which Naturally Grown and Widely Used in Hakkari. Res J Biol Sci 7: 21-25. Young IS, Woodside JV (2001). Antioxidants in health and disease. J Clin Pathol 54: 176-186.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Original Article
Yazarlar

Serpil Ugraş

Sultan Ülger Bu kişi benim

Pınar Göç Rasgele Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2019
Gönderilme Tarihi 28 Haziran 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 49 Sayı: 2

Kaynak Göster

APA Ugraş, S., Ülger, S., & Göç Rasgele, P. (2019). Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy, 49(2), 45-52.
AMA Ugraş S, Ülger S, Göç Rasgele P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. iujp. Ağustos 2019;49(2):45-52.
Chicago Ugraş, Serpil, Sultan Ülger, ve Pınar Göç Rasgele. “Evaluation of Biological Activity of Diplotaenia Cachrydifolia Boiss. That Medicinal Plant”. İstanbul Journal of Pharmacy 49, sy. 2 (Ağustos 2019): 45-52.
EndNote Ugraş S, Ülger S, Göç Rasgele P (01 Ağustos 2019) Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. İstanbul Journal of Pharmacy 49 2 45–52.
IEEE S. Ugraş, S. Ülger, ve P. Göç Rasgele, “Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant”, iujp, c. 49, sy. 2, ss. 45–52, 2019.
ISNAD Ugraş, Serpil vd. “Evaluation of Biological Activity of Diplotaenia Cachrydifolia Boiss. That Medicinal Plant”. İstanbul Journal of Pharmacy 49/2 (Ağustos 2019), 45-52.
JAMA Ugraş S, Ülger S, Göç Rasgele P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. iujp. 2019;49:45–52.
MLA Ugraş, Serpil vd. “Evaluation of Biological Activity of Diplotaenia Cachrydifolia Boiss. That Medicinal Plant”. İstanbul Journal of Pharmacy, c. 49, sy. 2, 2019, ss. 45-52.
Vancouver Ugraş S, Ülger S, Göç Rasgele P. Evaluation of biological activity of Diplotaenia cachrydifolia Boiss. that medicinal plant. iujp. 2019;49(2):45-52.