Plants used in traditional treatment of prostate diseases in Turkey

Yıl 2019, Cilt: 49 Sayı: 3, 191 - 203, 01.12.2019

Yunus Emre Şahin Meryem Şeyda Erbay , Sezin Anıl Roukie Kantar Şükran Kültür Gülay Melikoğlu

Öz

DOI: 10.26650/IstanbulJPharm.2019.19025

Turkey has a very rich flora and also many medicinal plants, due to its geography. In this study, it has been aimed to provide information about the plants used by people against prostate diseases in Turkey. It has been screened ethnobotanical studies made in various parts of the Turkey and 107 taxa used in treatment of prostate diseases have been recorded. These plants are belong to predominantly Rosaceae (15 taxa), Asteraceae (13 taxa), Lamiaceae (10 taxa), Poaceae (4 taxa), Anacardiaceae (3 taxa), Apiaceae (3 taxa), Brassicaceae (3 taxa) families. The plant parts used for treatment are leaves, aerial parts, flowers, roots and seeds. Flavonoids, essential oils, tannins, saponins, alkaloids, and steroids are the most common chemical compounds in these plants. Activity studies to support the use of prostate diseases for 17 taxa have been reached. Similar activity studies can be done for other plants and so new drugs can be developed for the treatment of prostate diseases.

You may cite this article as: Şahin YE, Erbay MŞ, Anıl S, Kantar R, Kültür Ş, Melikoğlu G (2019). Plants Used in Traditional Treatment Against Prostate Diseases in Turkey. Istanbul J Pharm 10.26650/IstanbulJPharm.2019.19025.

Anahtar Kelimeler

Prostate diseases, Medicinal plants, Traditional treatment, Turkey

Kaynakça

• 1 Abdallah OM, Ramadan MA, El-Shanawany MA (1989). Phytochemical study of Carduus nutans L. (Asteraceae). Bull. Pharm. Sci. Assiut Univ., 18(2):69-76. 2 Akan H, Bakır Sade Y (2015). Kahta (Adıyaman) merkezi ve Narince Köyü’nün etnobotanik açıdan araştırılması. BEÜ Fen Bilimleri Dergisi, 4(2):219-248. DOI: 10.17798/beufen.47724 3 Akalın E, Alpınar K (1994). Tekirdağ’ın tıbbi ve yenen bitkileri hakkında bir araştırma. Ege Üniv Ecz Fak Der, 2(1):1-11. 4 Akbulut S, Bayramoglu MM (2013). The trade and use of some medical and aromatic herbs in Turkey. Studies on Ethno-Medicine, 7(2): 67-77. 5 Al-Snafi, A. E. (2016). The chemical constituents and pharmacological effects of Convolvulus arvensis and Convolvulus scammonia-A review. IOSR Journal of Pharmacy, 6(6):64-75. 6 Altınyay Ç, Suntar İ, Altun L, Keleş H, Küpeli Akkol E (2016). Phytochemical and biological studies on Alnus glutinosa subsp. glutinosa, A. orientalis var. orientalis and A. orientalis var. pubescens leaves. J Ethnopharmacol, 192:148-160. https://doi.org/10.1016/j.jep.2016.07.007 7 Altundağ E, Öztürk M (2011). Ethnobotanical studies on the plant resources of East Anatolia, Turkey. The 2. International Geography Symposium GEOMED 2010. Procedia Soc Behav Sci, 19:756-777. https://doi.org/10.1016/j.sbspro.2011.05.195 8 Ansari M, Emami S (2016). β-Ionone and its analogs as promising anticancer agents. Eur J Med Chem, 123:141–154. https://doi.org/10.1016/j.ejmech.2016.07.037 9 Arslan Ö (2005). Dereli (Giresun) yöresinin geleneksel halk ilacı olarak kullanılan bitkileri. MSc Thesis. Marmara University, Turkey. 10 Avcıbaşı H, Anıl H, Toprak M (1988). Terpene acids from Cedrus libani. Phytochemistry., 27(12):3967-3968. https://doi.org/10.1016/0031-9422(88)83057-7 11 Azab, A. (2017). Arum: a plant genus with great medicinal potential. European Chemical Bulletin, 6(2): 59-68. 12 Badawy ESM, El-Sherbeny SE, El-Kady AFY, Amer H (2013). Influence of planting dates and distances on growth, yield and chemical constituents of Lallemantia iberica (Bieb.) Fisch. and Mey.. Plant J Appl Sci Res., 9(3):2093-2103. 13 Barnes J, Anderson LA, Phillipson D (2002). Herbal Medicines. 2th ed. London: Pharmaceutical Press. 14 Baytop T (1963). Türkiye’nin Tıbbi ve Zehirli Bitkileri. İsmail Akgün Matbaası, Istanbul. 15 Baytop T (1984). Türkiye’de Bitkiler ile Tedavi. Sanal Matbaacılık, Istanbul. 16 Baytop T (1999). Türkiye’de Bitkiler ile Tedavi, 2. baskı. Nobel Tıp Ktapevleri Ltd. Sti, Istanbul. 17 Baytop T and Gürkan E (1972). Türkiye’nin bazı Equisetum türleri (E. palustre L., E. ramosissimum Desf., E. telmantia Ehrh.) üzerinde farmakognozik araştırmalar. İst Üniv Ecz Fak Mec, 8:63-74. 18 Birinci S (2008). Doğu Karadeniz Bölgesi’nde doğal olarak bulunan faydalı bitkiler ve kullanım alanlarının araştırılması. MSc Thesis. Çukurova University, Turkey. 19 Bisset NG (1994). Herbal drugs and phytopharmaceuticals: A handbook for practice on a scientific basis. Medpharm Scientific Publishers, Stuttgart. 20 Brantner A, Maleš Ž, Pepeljnjak S, Antolić A (1996). Antimicrobial activity of Paliurus spina-christi Mill. (Christ’s thorn). J Ethnopharmacol, 52(2):119–122. doi:10.1016/0378-8741(96)01408-0. 21 Brendler T, Gruenwald J, Jaenicke C (2003). Herbal Remedies – Heilpflanzen on CD ROM, 5th ed. (Medpharm, Stuttgart). 22 Brooks JD, Paton VG, Vidanes G (2001). Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev., 10(9):949-954. 23 Bulut EG (2008) Bayramiç (Çanakkale) yöresinde etnobotanik araştırmalar. PhD Thesis. Marmara University, Turkey. 24 Bulut G, Haznedaroğlu MZ, Doğan A, Koyu H, Tuzlacı E (2017). An ethnobotanical study of medicinal plants in Acipayam (Denizli-Turkey). J Herb Med, 10:64-81. https://doi.org/10.1016/j.hermed.2017.08.001 25 Bulut G, Tuzlaci E (2013). An ethnobotanical study of medicinal plants in Turgutlu (Manisa-Turkey). J Ethnopharmacol, 149(3):633-647. 26 Calis I, Yürüker A, Roegger H, Wright AD, Sticher O (1995). Lanatoside, a monocyclic C10 iridoid glucoside from Viburnum lantana. Phytochemistry, 38(1):163-165. https://doi.org/10.1016/0031-9422(94)00585-H 27 Caliskan O (2015). Mediterranean Hawthorn Fruit (Crataegus) Species and Potential Usage. The Mediterranean Diet, Chapter 55: 621-628. doi:10.1016/b978-0-12-407849-9.00055-5 28 Carvalho AR, Costa G, Figueirinha A, Liberal J, Prior JAV, Lopes MC, Batista MT (2017). Urtica spp.: Phenolic composition, safety, antioxidant and anti-inflammatory activities. Food Research International, 99:485–494. doi:10.1016/j.foodres.2017.06.008 29 Colasanti A, Kisslinger A, Liuzzi R, Quarto M, Riccio P, Roberti G, et al. (2000). Hypericin photosensitization of tumor and metastatic cell lines of human prostate. J. Photochem. Photobiol., 54:103–107. https://doi.org/10.1016/S1011-1344(99)00149-9 30 Çalış İ, Hosny M, Lahloub MF (1996). A secoiridoid glucoside from Fraxinus angustifolia. Phytochemistry, 41(6):1557-1562. https://doi.org/10.1016/0031-9422(95)00815-2 31 Çubukçu B, Sarıyar G, Meriçli AH, Sütlüpınar N, Mat A, Meriçli F (2002). Fitoterapi Yardımcı Ders Kitabı. İ.Ü. Basım ve Yayınevi Müdürlüğü, Istanbul. 32 Çubukçu B, Yüksel V (1982). Constituents of Anatolian Medicinal Plants; Flavonoids of Helichrysum armenium. Journal of Natural Products, 45(2):137–139. doi:10.1021/np50020a005 33 Dehaghi NK, Lai D, Amanzadeh Y, Sadat-Ebrahimi SS, Proksch P (2012). A new putrescine bisamide phenolic glycoside from the seeds of Lallemantia iberica (M. Bieb.) Fisch. and CA Mey.. Phytochemistry Letters., 5(3):643-646. https://doi.org/10.1016/j.phytol.2012.06.013 34 Demir F, Özcan M (2001). Chemical and technological properties of rose (Rosa canina L.) fruits grown wild in Turkey. Journal of Food Engineering, 47(4): 333–336. doi:10.1016/s0260-8774(00)00129-1. 35 Demiray A (2013). Kozmetik amaçlı kullanım için kır menekşesinde (Viola odorata) bazı biyokimyasal aktivitelerin aranması ve tanımlanması. MSc Thesis. Muğla Sıtkı Koçman University, Turkey. 36 Demirci F, Güven K, Demirci B, Dadondi MY, Baser KHC (2008). Antibacterial activity of two Phlomis essential oils against food pathogens. Food Control., 19(12):1159-1164. 37 Demirci S, Özhatay N (2012). An ethnobotanical study in Kahramanmaraş (Turkey); wild plants used for medicinal pupose in Andırın, Kahramanmaraş. Turk J. Pharm. Sci., 9(1):75-92. 38 Demirezer Ö Ed. (2011). FED Monografları, Tedavide Kullanılan Bitkiler. MN Medikal and Nobel Tıp Kitapevi, Ankara. 39 Doğan A (2014). Pertek (Tunceli) yöresinde etnobotanik araştırmalar. PhD Thesis. Marmara University, Turkey. 40 Dujmović Purgar D, Duralija B, Voća S, Vokurka A, Ercisli S (2012). A comparison of fruit chemical characteristics of two wild grown Rubus species from different locations of Croatia. Molecules., 17(9):10390-10398. 41 Ecevit Genç G, Özhatay N (2006). An ethnobotanical study in Çatalca (European part of Istanbul) II. Turk J. Pharm. Sci., 3(2):73-89. 42 Edwards JE, Brown PN, Talent N, Dickinson TA, Shipley PR (2012). A review of the chemistry of the genus Crataegus. Phytochemistry, 79:5–26. doi:10.1016/j.phytochem.2012.04.006 43 Ergün F, Deliorman D. (1995). Farklı konakçılardaki Viscum album L. örneklerinin etken maddeleri yönünden incelenmesi. J. Fac. Pharm. Ankara, 24.2:21-33. 44 Erken S, Malyer H, Demirci F, Demirci B, Baser KHC (2001). Chemical investigations on some Hypericum species growing in Turkey-I. Chem Nat Compd, 37(5):434-438. https://doi.org/10.1023/A:1014463124907 45 Eşen B (2008). Aydınlar köyü ve çevresinin (Erdemli/Mersin) etnobotanik özellikleri. MSc Thesis. Selçuk University, Turkey. 46 Evans WC (2002). Trease and Evans Pharmacognosy, 15th ed. WB Saunders Company Limited, London. 47 Ezer N, Arısan ÖM (2006). Folk medicines in Merzifon (Amasya, Turkey). Turk J Bot, 30:223-230. 48 Fakir H, Korkmaz M, Güller B (2009). Medicinal plant diversity of western Mediterrenean region in Turkey. Journal of Applied Biological Sciences, 3(2):30-40. 49 Flamini G, Cioni PL, Morelli I (2005). Composition of the essential oils and in vivo emission of volatiles of four Lamium species from Italy: L. purpureum, L. hybridum, L. bifidum and L. amplexicaule. Food Chem, 91(1):63-68. https://doi.org/10.1016/j.foodchem.2004.05.047 50 Francescato LN, Debenedetti SL, Schwanz TG, Bassani VL, Henriques AT (2013). Identification of phenolic compounds in Equisetum giganteum by LC–ESI-MS/MS and a new approach to total flavonoid quantification. Talanta, 105:192–203. doi:10.1016/j.talanta.2012.11.072 51 Fujita T, Sezik E, Tabata M, Yeşilada E, Honda G, Takeda Y, et al. (1995). Traditional medicine in Turkey VII. Folk medicine in middle and west Black Sea regions. Econ Bot, 49(4):406-422. https://doi.org/10.1007/BF02863092 52 Galeone C, Pellucchi C, Talamini R, Negri E, Maso LD, Montella M, et al. (2007). Onion and garlic intake and the odds of benign prostatic hyperplasia. Urology, 70(4):672-676. https://doi.org/10.1016/j.urology.2007.06.1099 53 Glasby JS (1991). Dictionary of plants containing secondary metabolites. Taylor and Francis Ltd., London. 54 Guatam N, Mantha AK, Mittal S (2014). Essential oils and their constituents as anticancer agents: a mechanistic view. Biomed Res Int, 2014:1-23. http://dx.doi.org/10.1155/2014/154106 55 Guyton AC, Hall JE, Çavuşoğlu H, Yeğen BÇ, Aydın Z, Alican İ (2007). Tıbbi Fizyoloji (11. Basım). Nobel Tıp Kitabevleri, Istanbul, 996-1010. 56 Güner A, Özhatay N, Ekim T, Başer KHC (2000). Flora of Turkey and the East Aegean Islands, Vol 11 (Suplement II). Edinburg University Press, UK. 57 Güneş F (2017). Medicinal plants used in the Uzunköprü district of Edirne, Turkey. Acta Societatis Botanicorum Poloniae, 86(4):3565. https://doi. org/10.5586/asbp.3565 58 Güneş F, Özhatay N (2011). An ethnobotanical study from Kars (Eastern) Turkey. Biological Diversity and Conservation, 4(1):30-41. 59 Güneş S, Savran A, Paksoy MY, Koşar M, Çakılcıoğlu U (2017). Ethnopharmacological survey of medicinal plants in Karaisalı and its surrounding (Adana-Turkey). J Herb Med, 8:68-75. https://doi.org/10.1016/j.hermed.2017.04.002 60 Gürdal B (2010). Marmaris (Muğla) ilçesinde etnobotanik bir araştırma. MSc Thesis. Istanbul University, Turkey. 61 Gürdal B, Kültür Ş (2013). An ethnobotanical study of medicinal plants in Marmaris (Muğla, Turkey). J Ethnopharmacol, 146:113-126. https://doi.org/10.1016/j.jep.2012.12.012 62 Gürkan E (2007). Bitkisel Tedavi. Istanbul Eczacı Odası Yay. 63 Güzel Y, Güzelşemme M, Miski M (2015). Ethnobotany of medicinal plants used in Antakya: a multicultural district in Hatay Province of Turkey. J Ethnopharmacol, 174:118-152. 64 Hartmann RW, Markz M, Soldati F (1996). Inhibition of 5 a-reductase and aromatase by PHL-00B01 (Prostatonin®), a combination of PY 102 (Pygeum africanum) and UR 102 (Urtica dioica) extracts. Phytomedicine, 3(2):121-128. https://doi.org/10.1016/S0944-7113(96)80025-0 65 Granica S, Czerwińska ME, Żyżyńska-Granica B, Kiss AK (2013). Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. Fitoterapia, 91:180–188. doi:10.1016/j.fitote.2013.08.026 66 Hassanzadeh Z, Hassanpour H (2018). Evaluation of physicochemical characteristics and antioxidant properties of Elaeagnus angustifolia L. Scientia Horticulturae, 238:83–90. doi:10.1016/j.scienta.2018.04.041 67 Internet source 1. Prostatit (Prostat İltihabı) Nedir? Prostatit Belirtileri ve Tedavisi. Web page: http://www.safahastanesi.com.tr/saglik-kosesi/Prostatit-(Prostat-Iltihabi)-Nedir-Prostatit-Belirtileri-ve-Tedavisi (Date accesed: 03.15.2017) 68 Internet source 2. Sarı C. Prostat Nedir? Prostat Belirtileri, Nedenleri ve Tedavisi. Web page: http://www.safahastanesi.com.tr/saglik-kosesi/Prostat-Nedir-Prostat-Belirtileri-Nedenleri-ve-Tedavisi (Date accesed: 03.15.2017) 69 Internet source 3. Prostat Kanseri Nedir? Belirtileri, Nedenleri, Evreleri ve Tedavisi. Web page: http://www.safahastanesi.com.tr/saglik-kosesi/Prostat-Kanseri-Nedir-Belirtileri-Nedenleri-Evreleri-ve-Tedavisi (Date accesed: 03.15.2017) 70 Isaikina NV, Kalinkina GI, Andreeva VY, Sherstoboev EY, Masnaya NV, Shilova AB (2015). Rowan (Sorbus aucuparia L.): Determination of antocyans in the berries. Farmatsiya (Moscow, Russian Federation)., 1:19-22. 71 Jaiswal R, Matei MF, Deshphande S, Kuhnert N (2014). Identification and characterization of hydroxycinnamates of six Galium species from the Rubiaceae family. Handb Chem Biol Plant Anal Methods, 2:505-524. https://doi.org/10.1002/9780470027318.a9922 72 Jena AK, Vasisht K, Sharma N, Kaur R, Dhingra MS, Karan M (2016). Amelioration of testosterone induced benign prostatic hyperplasia by Prunus species. J Ethnopharmacol, 190:33–45. https://doi.org/10.1016/j.jep.2016.05.052 73 Joaquin De PT, Julio GU, Isidro SM, Pilar BB, Narciso MG (1986). Diterpenoid and other components of Cistus laurifolius. Phytochemistry., 25(5):1185-1187. https://doi.org/10.1016/S0031-9422(00)81577-0 74 Jones S, Fernandes NV, Yeganehjoo H, Katuru R, Qu H, Yu Z, Mo H (2013). β-Ionone induces cell cycle arrest and apoptosis in human prostate tumor cells. Nutr Cancer, 65(4):600-610. https://doi.org/10.1080/01635581.2013.776091 75 Kahraman A, Tatlı A (2004). Umurbaba Dağı (Eşme-Uşak) ve çevresindeki bazı bitkilerin mahalli adları ve etnobotanik özellikleri. Ot Sistematik Botanik Dergisi., 11(2):147-154. 76 Kam SC, Do JM, Choi JH, Jeon BT, Roh GS, Hyun JS (2012). In vivo and in vitro animal investigation of the effect of a mixture of herbal extracts from Tribulus terrestris and Cornus officinalis on penile erection. J Sex Med, 9(10):2544-2551. https://doi.org/10.1111/j.1743-6109.2012.02889.x 77 Karakurt E (2014). Kelkit (Gümüşhane) ilçesinin etnobotanik özellikleri. MSc Thesis. Erzincan University, Turkey. 78 Kartal Ç, Güneş F (2017). Medicinal Plants Used in Meriç Town from Turkey. Indian J Pharm Educ Res, 51(3):249-53. DOI: 10.5530/ijper.51.3s.23 79 Kaval İ, Behçet L, Cakilcioglu U (2014). Ethnobotanical study on medicinal plants in Geçitli and its surrounding (Hakkari-Turkey). J Ethnopharmacol, 155(1):171-184. https://doi.org/10.1016/j.jep.2014.05.014 80 Kayabaşı NP (2011). Manyas ve köylerinde etnobotanik bir çalışma. Unpublished MSc Thesis. Balıkesir University, Turkey. 81 Keklik T (1990). Konya ili halk ilaçları. Unpublished MSc Thesis. Istanbul University, Turkey. 82 Keskin L (2011). Kadınhanı (Konya) ve çevresinde yetişen bitkilerin etnobotanik özellikleri. Unpublished MSc Thesis. Selçuk University, Turkey. 83 Kızılarslan Ç, Özhatay N (2012). Wild plants used as medicinal purpose in the south part of İzmit (Northwest Turkey). Turk J. Pharm. Sci., 9(2):199-218. 84 Koca HB, Köken T, Özkurt M, et al. (2018). Effects of Acorus calamus plant extract on prostate cancer cell culture. Anatolian J Bot, 2(1):46-51. doi:10.30616/ajb.391985 85 Koçak S (1999). Karaman yöresinde etnobotanik bir araştırma. Unpublished MSc Thesis. Istanbul University, Turkey. 86 Koçyiğit M(2005)Yalova ilinde etnobotanik bir araştırma. MSc Thesis. Istanbul University, Turkey. 87 Korkmaz M, Alparslan Z (2015). Ergan Dağı (Erzincan-Türkiye)’nın etnobotanik özellikleri. Bağbahçe Bilim Dergisi, 1(3):1-31. 88 Korkmaz M, Karakurt E (2014). Kelkit (Gümüşhane) Aktarlarında Satılan Tıbbi Bitkiler. Journal of Natural & Applied Sciences, 18(3):60-80. 89 Koulman A, Konukgil B, Evren H (2005). Ariltetralin lignans from Linum mucronatum Bertol ssp. mucronatum. Chem Nat Compd, 41(1):30-31. https://doi.org/10.1007/s10600-005-0067-1 90 Koyuncu O (2005). Geyve (Sakarya) ve çevresinin floristik ve etnobotanik açıdan incelenmesi. PhD Thesis. Eskişehir Osmangazi University, Turkey. 91 Koz O, Pizza C, Kırmızıgül S (2009). Triterpene and flavones glycosides from Anchusa undulata subsp. hybrida. Nat Prod Res, 23(3):284-292. https://doi.org/10.1080/14786410802006140 92 Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C (2012). 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment. J Ethnopharmacol, 139(3):765-771. https://doi.org/10.1016/j.jep.2011.12.010 93 Kumar V, Kural MR, Pereira BMJ, Roy P (2008). Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats-altered levels of gene expression, enzymes and hormones. Food Chem Toxicol., 46(12):3563-3570. https://doi.org/10.1016/j.fct.2008.08.027 94 Küçükbezirci S (1967). Konya ve dolaylarında halk ilaçları. Türk Folklor Araştırmaları, 13:43-94. 95 Kültür Ş (2007). Medicinal plants used in Kırklareli province (Turkey). J Ethnopharmacol, 111:341-364. https://doi.org/10.1016/j.jep.2006.11.035 96 Lee J, Lee S, Kim SL, Choi JW, Seo JY, Choi DJ, et al. (2014). Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway. Life Sci, 119(1):47-55. https://doi.org/10.1016/j.lfs.2014.10.012 97 Long N, Suzuki S, Sato S, Naiki-Ito A, Sakatani K, Shirai T, Takahashi S (2013). Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Cancer Sci,104(3):298-303. 98 Mahboubi M (2017). Effectiveness of Myrtus communis in the treatment of hemorrhoids. Journal of Integrative Medicine, 15(5):351-358. doi:10.1016/s2095-4964(17)60340-6 99 Melikoğlu G, Meriçli AH, Meriçli F (1999). Flavonoids of Crataegus orientalis. Boll. Chim.Farmaceutica, 138:351-352. 100 Mercan SY (2006). Rubus hirtus Waldst. and Kit. bitkisi üzerinde farmakognozik araştırmalar. MSc Thesis. Marmara University, Turkey. 101 Metin A (2009). Mut ve çevresinde yetişen bitkilerin (Mersin) etnobotanik özellikleri. Unpublished MSc Thesis. Selçuk University, Turkey. 102 Mirahmadi SF, Norouzi R (2017). Chemical composition, phenolic content, free radical scavenging and antifungal activities of Achillea biebersteinii. Food Biosci., 18:53-59. https://doi.org/10.1016/j.fbio.2017.04.004 103 Mohamed TA, Tawfik WA, Hassan EM, Soleiman E, Hussein TA, Shahat AA (2015). First isolation and characterization of chemical constituents from Achillea biebersteinii. Res J Pharm Biol Chem Sci., 6(6):1179. 104 Mzid M, Ghlissi Z, Salem MB, Khedir SB, Chaabouni K, Ayedi F, Rebai T (2018). Chemoprotective role of ethanol extract of Urtica urens L. against the toxicity of imidacloprid on endocrine disruption and ovarian morphometric in female rats, GC/MS analysis. Biomedicine & Pharmacotherapy, 97:518–527. doi:10.1016/j.biopha.2017.10.150 105 Nakic SN, Rade D, Kevin D, Trucelj D, Mokrovcak Z, Bartolic M (2006). Chemical characteristics of oils from naked and husk seeds of Cucurbita pepo L.. Eur. J. Lipid Sci. Technol., 108:936-943. https://doi.org/10.1002/ejlt.200600161 106 Oke F, Aslim B, Ozturk S, Altundag S (2009). Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten. Food Chem, 112(4):874-879. https://doi.org/10.1016/j.foodchem.2008.06.061 107 Oksuz S, Topcu G (1994). Guaianolides from Centaurea glastifolia. Phytochemistry., 37(2):487-490. https://doi.org/10.1016/0031-9422(94)85084-4 108 Oral DÇ (2007). Konya ilinde kullanılan halk ilaçları üzerinde etnobotanik araştırmalar. Unpublished MSc Thesis. Gazi University, Turkey. 109 Özçelik H, Balabanlı C (2005). Burdur ilinin tıbbi ve aromatik bitkileri. 1. Burdur Sempozyumu. 1127 s. 110 Özdemir E, Alpınar K (2015). An ethnobotanical survey of medicinal plants in western part of central Taurus Mountains: Aladaglar (Nigde–Turkey). J Ethnopharmacol, 166:53-65. 111 Özgökçe F, Özçelik H (2004). Ethnobotanical aspects of some taxa in East Anatolia (Turkey). Econ Bot, 58(4):697-704. https://doi.org/10.1663/0013-0001(2004)058[0697:EAOSTI]2.0.CO;2 112 Özhatay N, Kültür Ş, Gürdal B (2013). Check-list of Additional Taxa to the Supplement Flora of Turkey VI. J. Fac. Pharm. Istanbul., 43(1):33-82. http://dergipark.gov.tr/iujfp/issue/582/5854 113 Özhatay N, Kültür Ş, Gürdal B (2015). Check-list of Additional Taxa to the Supplement Flora of Turkey VII. J. Fac. Pharm. Istanbul., 45(1):61-86. http://dergipark.gov.tr/iujfp/issue/25584/269882 114 Özhatay N, Kültür Ş, Gürdal B (2017). Check-list of Additional Taxa to the Supplement Flora of Turkey VIII. J. Fac. Pharm. Istanbul., 47(1):31-46. DOI:10.5152/IstanbulJPharm.2017.006 115 Öztürk M, Uysal I, Günvel S, Altundağ E, Doğan Y, Başlar S (2013). Medicinal uses of natural dye-yielding plants in Turkey. Res J Text Apparel, 17(2):69-80. https://doi.org/10.1108/RJTA-17-02-2013-B010 116 Pappa G, Lichtenberg M, Iori R, Barillari J, Bartsch H, Gerhauser C (2006). Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Mutat Res, 599(1-2):76-87. https://doi.org/10.1016/j.mrfmmm.2006.01.007 117 Paucar-Menacho LM, Martinez-Villaluenga C, Duenas M, Frias J, Penas E (2017). Optimization of germination time and temperature to maximize the content of bioactive compounds and the antioxidant activity of purple corn (Zea mays L.) by response surface methodology. LWT - Food Sci Technol, 76:236-244. https://doi.org/10.1016/j.lwt.2016.07.064 118 PDR for Herbal Medicines, 4th Edition (2007). Thomson Healthcare. 119 Polat R (2010). Havran ve Burhaniye (Balıkesir) çevresinde tarımsal biyoçeşitlilik ve etnobotanik araştırmaları. PhD Thesis Balıkesir University, Turkey. 120 Polat R, Cakilcioglu U, Kaltalioğlu K, Ulusan MD, Türkmen Z (2015). An ethnobotanical study on medicinal plants in Espiye and its surrounding (Giresun-Turkey). J Ethnopharmacol, 163:1-11. 121 Polat R, Satıl F (2012). An ethnobotanical survey of medicinal plants in Edremit Gulf (Balıkesir–Turkey). J Ethnopharmacol, 139(2):626-641. 122 Ramos JA, Bianco FJ (2012). The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. Indian J Urol., 28(1):9-14. doi: 10.4103/0970-1591.94942 123 Raudone L, Zymone K, Raudonis R, Vainoriene R, Motiekaityte V, Janulis V (2017). Phenological changes in triterpenic and phenolic composition of Thymus L. species. Ind Crops Prod, 109:445-451. https://doi.org/10.1016/j.indcrop.2017.08.054 124 Rezig L, Chouaibi M, Msaada K, Hamdi S (2012). Chemical composition and profile characterisation of pumpkin (Cucurbita maxima) seed oil. Industrial Crops and Products, 37(1):82-87. doi:10.1016/j.indcrop.2011.12.004 125 RX Media Pharma. 2017. 126 Sadhu SK, Okuyama E, Fujimoto H, Ishibashi M, Yesilada E (2006). Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant. J Ethnopharmacol, 108:371-378. https://doi.org/10.1016/j.jep.2006.05.024 127 Saglik S, Alpinar K, Imre S (2002). Fatty acid composition of Dracunculus vulgaris Schott (Araceae) seed oil from Turkey. J Pharm Pharmaceut Sci, 5:231-233. 128 Sağıroğlu M, Dalgıç S, Toksoy S (2013). Medicinal plants used in Dalaman (Muğla), Turkey. J Med Plants Res., 7(28):2053-2066. https://doi.org/10.5897/JMPR2013.2590 129 Samuelsen AB (2000). The traditional uses, chemical constituents and biological activities of Plantago major L. A review. J Ethnopharmacol, 71(1-2):1–21. doi:10.1016/s0378-8741(00)00212-9 130 Saraç DU, Özkan ZC, Akbulut S (2013). Ethnobotanic features of Rize/Turkey province. Biological Diversity and Conservation, 6(3):57-66. 131 Sargin SA (2015). Ethnobotanical survey of medicinal plants in Bozyazı district of Mersin, Turkey. J Ethnopharmacol, 173:105-126. 132 Sargın SA, Akçiçek E, Selvi S (2013). An ethnobotanical study of medicinal plants used by the local people of Alaşehir (Manisa) in Turkey. J Ethnopharmacol, 150(3):860-874. https://doi.org/10.1016/j.jep.2013.09.040 133 Sargın SA, Selvi S, López V (2015). Ethnomedicinal plants of Sarigöl district (Manisa), Turkey. J Ethnopharmacol, 171:64-84. 134 Sarıkan I (2007). Kazdağları yöresinin geleneksel ilaçlarının saptanması. Unpublished MSc Thesis. Ege University, Turkey. 135 Sarıözkan S, Türk G, Eken A, Bayram LÇ, Baldemir A, Doğan G (2017). Gilaburu (Viburnum opulus L.) fruit extract alleviates testis and sperm damages induced by taxane-based chemotherapeutics. Biomedicine & Pharmacotherapy, 95:1284–1294. doi:10.1016/j.biopha.2017.09.057 136 Sayık A (2007). Yakı otu (Epilobium angustifolium) bitkisinin kimyasal yapısının incelenmesi. Unpublished MSc Thesis. Istanbul University Turkey. 137 Sen A, de Melo MMR, Silvestre AJD, Pereira H, Silva CM (2015). Prospective pathway for a green and enhanced friedelin production through supercritical fluid extraction of Quercus cerris cork. J Supercrit Fluid., 97:247-255. https://doi.org/10.1016/j.supflu.2014.12.008 138 Serçe S, Özgen M, Torun AA, Ercişli S (2010). Chemical composition, antioxidant activities and total phenolic content of Arbutus andrachne L. (Fam. Ericaceae) (the Greek strawberry tree) fruits from Turkey. Journal of Food Composition and Analysis, 23(6):619-623. doi:10.1016/j.jfca.2009.12.007 139 Sezik E, Aslan M (1997). Helichrysum plicatum DC. subsp. plicatum’un uçucu yağı. In: Abstract Book of Proceeding of the XIth Symposium on Plant Originated Crude Drugs, Ankara, May 22-24,1996, (Ed. Coşkun M). Ankara Üniversitesi Eczacılık Fakültesi Yayınevi. 565 s. 140 Sezik E, Ustun O, Demirci B, Husnu C, Baser K (2010). Composition of the essential oils of Pinus nigra Arnold from Turkey. Turk J. Chem., 34:313-325. doi:10.3906/kim-0903-39 141 Shari Moghadem A, Mehrafarin A, Naghdi Badi H (2017). Chemical composition and antioxidant activity Achillea millefolium L. essential oils. J Essent Oil-Bear Plants., 20(1):293-297. https://doi.org/10.1080/0972060X.2016.1238323 142 Smith JA, Paterson GR (1967). Rhodexin A and rhodexoside in Ornithogalum umbellatum. Journal of Pharmacy and Pharmacology, 19(4):221–225. doi:10.1111/j.2042-7158.1967.tb08075.x 143 Şabudak T, Oyman Ü (2002). Phytochemical studies at the bulbs of Ornithogalum Umbellatum L. Turkish Journal of Chemistry, 26(3):453-456. 144 Şenkardeş İ (2014). Nevşehir’in güney ilçelerinde (Acıgöl, Derinkuyu, Gülşehir, Nevşehir-Merkez, Ürgüp) etnobotanik araştırmalar. PhD Thesis. Marmara University, Turkey. 145 Şenkardeş İ, Tuzlacı E (2014). Some Ethnobotanical Notes from Gundogmus District (Antalya/Turkey). Clinical and Experimental Health Sciences, 4(2):63. 146 Şığva ZÖD (2012). Prostat kanseri hücre hatlarında paklitaksel ile bitkisel etken maddelerin ve endemik bitki ekstrelerinin sinerjistik etkisinin hücre döngüsü ve apoptoz sinyal iletim yolakları üzerine etkisinin araştırılması. Unpublished PhD Thesis. Ege University, Turkey. 147 Tang Y, Li N, Duan J, Tao W (2013). Structure, Bioactivity, and Chemical Synthesis of OSW-1 and Other Steroidal Glycosides in the Genus Ornithogalum. Chemical Reviews, 113(7):5480–5514. doi:10.1021/cr300072s 148 Tanker M, Tanker N (2003). Farmakognozi Cilt 1-2. Ankara Üniveristesi Basımevi. 149 Tatlı II, Schuhly X, Akdemir ZS (2007). Secondery metabolites from bioactive methanolic extract of Verbascum pycnostachyum Boiss. and Helder flowers. Hacettepe Univ J Fac Pharm, 27(1):23. 150 Tepe B, Sokmen M, Akpulat HA, Daferera D, Polissiou M, Sokmen A (2005). Antioxidative activity of the essential oils of Thymus sipyleus subsp. sipyleus var. sipyleus and Thymus sipyleus subsp. sipyleus var. rosulans. J Food Eng, 66(4):447-454. https://doi.org/10.1016/j.jfoodeng.2004.04.015 151 Tetik F (2011). Malatya ilinin etnobotanik değeri olan bitkileri üzerine bir araştırma. Unpublished MSc Thesis. Fırat University, Turkey. 152 Tetik F, Civelek S, Cakilcioglu U (2013). Traditional uses of some medicinal plants in Malatya (Turkey). J Ethnopharmacol, 146(1):331-346. 153 Tomczyk M, Gudej J (2005). Polyphenolic compounds from Rubus saxatilis. Chemistry of natural compounds, 41(3):349-351. 154 Topaloğlu M (1987). Antakya bölgesinin gıda ve ilaç olarak kullanılan bitkileri üzerinde araştırmalar. Unpublished MSc Thesis. Istanbul University, Turkey. 155 Trabelsi H, Cherif OA, Sakouhi F, Villeneuve P, Renaud J, Barouhn N, et al. (2012). Total lipid content, fatty acids and 4-desmethylsterols accumulation in developing fruit of Pistacia lentiscus L. growing wild in Tunisia Food Chem, 131:434-440. https://doi.org/10.1016/j.foodchem.2011.08.083 156 Trease GE, Evans WC (2009). Pharmacognosy. 16th Ed. Oxford University Press, New York. 157 Tuzlacı E (2006). Şifa Niyetine, Türkiye’nin Bitkisel Halk İlaçları. Alfa Basım Yayım Dağıtım, Istanbul. 158 Tuzlacı E, Alparslan DF (2007). Turkish folk medicinal plants, part V: Babaeski (Kırklareli). J Fac Pharm Istanbul Univ, 39:11. 159 Tuzlacı E, Alparslan FD, Bulut G (2010). Turkish folk medicinal plants, VIII: Lalapaşa (Edirne). Marmara Pharm J, 14:47-52. DOI: 10.12991/201014463 160 Tuzlacı E and Erol MK (1999). Turkish folk medicinal plants, part II: Eğirdir-Isparta. Fitoterapia., 70:593-610. https://doi.org/10.1016/S0367-326X(99)00074-X 161 Tyler VE, Brady LR, Robbers JE (1988). Pharmacognosy. 9th ed. Lea and Febiger, Philedelphia. 162 Uzun E, Sarıyar G, Adsersen A, Karakoç B, Ötük G, Oktayoğlu E, et al. (2004). Traditional medicine in Sakarya province (Turkey) and antimicrobial activities of selected species. J Ethnopharmacol, 95(2):287-296. https://doi.org/10.1016/j.jep.2004.07.013 163 Yeşilyurt EB, Şimşek I, Akaydin G, Yeşilada E (2017). An ethnobotanical survey in selected districts of the Black Sea region (Turkey). Turk J Bot, 41(1):47-62. doi:10.3906/bot-1606-12 164 Younis YMH, Ghirmay S, Al-Shihry SS (2000). African Cucurbita pepo L.: properties of seed and variability in fatty acid composition of seed oil. Phytochemistry, 54(1):71-75.