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Yıl 2022, Cilt: 52 Sayı: 1, 1 - 7, 28.04.2022
https://doi.org/10.26650/IstanbulJPharm.2022.937821

Öz

Kaynakça

  • Baker, M., & Perazella, M. A. (2020). NSAIDs in CKD: Are they safe? American Journal of Kidney Diseases, 76(4), 546–557. https://doi. org/10.1053/j.ajkd.2020.03.023
  • Bakris, G. L., & Weir, M. R. (2000). Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: Is this a cause for concern? Archives of Internal Medicine, 160(5), 685–693. https:// doi.org/10.1001/archinte.160.5.685
  • Chan, J. C., Critchley, J. A., Lappe, J. T., Raskin, S. J., Snavely, D., Gold- berg, A. I., & Sweet, C. S. (1995). Randomised, double-blind, paral- lel study of the anti-hypertensive efficacy and safety of losartan potassium compared with felodipine ER in elderly patients with mild to moderate hypertension. Journal of Human Hypertension, 9(9), 765–771.
  • Collard, D., Brouwer, T. F., Peters, R. J. G., Vogt, L., & van den Born, B.-J. H. (2018). Creatinine Rise during blood pressure therapy and the risk of adverse clinical outcomes in patients with type 2 dia- betes mellitus. Hypertension (Dallas, Tex.: 1979), 72(6), 1337–1344. https://doi.org/10.1161/HYPERTENSIONAHA.118.11944
  • Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P. … Levey, A. S. (2007). Prevalence of chronic kidney disease in the United States. JAMA, 298(17), 2038–2047. https://doi.org/10.1001/ jama.298.17.2038
  • Council on Credentialing in Pharmacy, Albanese, N. P., & Rouse, M. J. (2010). Scope of contemporary pharmacy practice: Roles, responsibilities, and functions of pharmacists and pharmacy technicians. Journal of the American Pharmacists Association: JAPhA, 50(2), e35-69. https://doi.org/10.1331/JAPhA.2010.10510
  • Doggrell, S. A. (2001). Is Ramipril the pril for diabetes and kidney disease? Drugs of Today (Barcelona, Spain: 1998), 37(5), 321–331. https://doi.org/10.1358/dot.2001.37.5.627954
  • Duan, J., Wang, C., Liu, D., Qiao, Y., Pan, S., Jiang, D. … Liu, Z. (2019). Prevalence and risk factors of chronic kidney disease and dia- betic kidney disease in Chinese rural residents: A cross-sectional survey. Scientific Reports, 9(1), 10408. https://doi.org/10.1038/ s41598-019-46857-7
  • Esposito, C., Bellotti, N., Fasoli, G., Foschi, A., Plati, A. R., & Dal Canton, A. (2004). Hyperkalemia-induced ECG abnormalities in patients with reduced renal function. Clinical Nephrology, 62(6), 465–468. https://doi.org/10.5414/cnp62465
  • Hallan, S. I., Coresh, J., Astor, B. C., Åsberg, A., Powe, N. R., Romund- stad, S., … Holmen, J. (2006). International Comparison of the relationship of chronic kidney disease prevalence and ESRD risk. Journal of the American Society of Nephrology, 17(8), 2275–2284. https://doi.org/10.1681/ASN.2005121273
  • Hou, F. F., Xie, D., Zhang, X., Chen, P. Y., Zhang, W. R., Liang, M. … Jiang, J. P. (2007). Renoprotection of Optimal Antiproteinuric Dos- es (ROAD) Study: A randomized controlled study of benazepril and losartan in chronic renal insufficiency. Journal of the Ameri- can Society of Nephrology: JASN, 18(6), 1889–1898. https://doi. org/10.1681/ASN.2006121372
  • James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Him- melfarb, C., Handler, J. … Ortiz, E. (2014). 2014 Evidence-Based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA, 311(5), 507–520. https://doi. org/10.1001/jama.2013.284427
  • Kahvecioglu, S., Akdag, I., Gullulu, M., Arabul, M., Ersoy, A., Dilek, K. … Yurtkuran, M. (2007). Comparison of higher dose of losartan treatment with losartan plus carvedilol and losartan plus ramipril in patients with glomerulonephritis and proteinuria. Renal Failure, 29(2), 169–175. https://doi.org/10.1080/08860220601098839
  • Knoll, G. A., Cantarovitch, M., Cole, E., Gill, J., Gourishankar, S., Hol- land, D. … Fergusson, D. (2008). The Canadian ACE-inhibitor trial to improve renal outcomes and patient survival in kidney trans- plantation—Study design. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Asso- ciation - European Renal Association, 23(1), 354–358. https://doi. org/10.1093/ndt/gfm574
  • Magvanjav, O., Cooper-DeHoff, R. M., McDonough, C. W., Gong, Y., Segal, M. S., Hogan, W. R., & Johnson, J. A. (2019). Antihyperten- sive therapy prescribing patterns and correlates of blood pres- sure control among hypertensive patients with chronic kidney disease. Journal of Clinical Hypertension (Greenwich, Conn.), 21(1), 91–101. https://doi.org/10.1111/jch.13429
  • Maione, A., Annemans, L., & Strippoli, G. (2009). Proteinuria and Clin- ical outcomes in hypertensive patients. American Journal of Hyper- tension, 22(11), 1137–1147. https://doi.org/10.1038/ajh.2009.161
  • Mandal, A. K. (1997). Hypokalemia and hyperkalemia. The Medical Clinics of North America, 81(3), 611–639. https://doi.org/10.1016/ s0025-7125(05)70536-8
  • Ono, T., Sanai, T., Miyahara, Y., & Noda, R. (2013). Olmesartan is more effective than other angiotensin receptor antagonists in reducing proteinuria in patients with chronic kidney disease other than diabetic nephropathy. Current Therapeutic Research,
  • Clinical and Experimental, 74, 62–67. https://doi.org/10.1016/j.cur- theres.2013.02.002
  • Palmer, B. F. (2004). Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system. The New England Journal of Medicine, 351(6), 585–592. https://doi.org/10.1056/ NEJMra035279
  • Praga, M., Andrade, C. F., Luño, J., Arias, M., Poveda, R., Mora, J. … Campistol, J. M. (2003). Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: A double-blind, randomized clinical trial. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialy- sis and Transplant Association - European Renal Association, 18(9), 1806–1813. https://doi.org/10.1093/ndt/gfg284
  • Reardon, L. C., & Macpherson, D. S. (1998). Hyperkalemia in out- patients using angiotensin-converting enzyme inhibitors. How much should we worry? Archives of Internal Medicine, 158(1), 26–32. https://doi.org/10.1001/archinte.158.1.26
  • Ripley, E., & Hirsch, A. (2010). Fifteen years of losartan: What have we learned about losartan that can benefit chronic kidney dis- ease patients? International Journal of Nephrology and Renovascu- lar Disease, 3, 93–98.
  • Sadjadi, S. A., McMillan, J. I., Jaipaul, N., Blakely, P., & Hline, S. S. (2009). A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers. Therapeutics and Clinical Risk Man- agement, 5(3), 547–552. https://doi.org/10.2147/tcrm.s5176
  • Schmidt, M., Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sørensen, H. T., Smeeth, L., & Tomlinson, L. A. (2017). Serum creatinine el- evation after renin-angiotensin system blockade and long term cardiorenal risks: Cohort study. BMJ, 356, j791. https://doi. org/10.1136/bmj.j791
  • Tikkanen, I., Omvik, P., & Jensen, H. A. (1995). Comparison of the angiotensin II antagonist losartan with the angiotensin convert- ing enzyme inhibitor enalapril in patients with essential hyper- tension. Journal of Hypertension, 13(11), 1343–1351. https://doi. org/10.1097/00004872-199511000-00017
  • Weir, M. R. (1999). Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency? American Journal of Hypertension, 12(S9), 195S-203S. https://doi. org/10.1016/S0895-7061(99)00104-1
  • Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C. … Wright, J. T. (2018). 2017 ACC/AHA/ AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Hypertension, 71(6), e13–e115. https://doi. org/10.1161/HYP.0000000000000065
  • Zhang, Y., He, D., Zhang, W., Xing, Y., Guo, Y., Wang, F., … Lin, S. (2020). ACE Inhibitor benefit to kidney and cardiovascular out- comes for patients with non-dialysis chronic kidney disease stages 3-5: A network meta-analysis of randomised clinical tri- als. Drugs, 80(8), 797–811. https://doi.org/10.1007/s40265-020- 01290-3.

The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease

Yıl 2022, Cilt: 52 Sayı: 1, 1 - 7, 28.04.2022
https://doi.org/10.26650/IstanbulJPharm.2022.937821

Öz

Background and Aims: The Joint National Committee 8th guideline recommends the initiation of renin angiotensin aldoste- rone system (RAAS)-linked drugs for hypertensive patients with chronic kidney disease (CKD). Losartan, an angiotensin receptor blocker (ARB), and ramipril, angiotensin converting enzyme (ACE) inhibitors, are widely utilized antihypertensive agents with sound efficacy and safety. The study compared the hyperkalemia incidences in CKD patients exposed to losartan and ramipril.
Methods: A prospective observational study was conducted for 12 months in the nephrology outpatient setting of a private tertiary care referral hospital in the Malabar region of Kerala. CKD patients with hypertension who were on ACE inhibitors or ARB therapy constituted our study population. Their demographic details, serum creatinine and potassium and urine protein were documented for three consecutive patient consultations.
Results: There were an equal number of samples (n=186) in each of the losartan and ramipril administered groups. Losar- tan and ramipril doses preferred by the nephrologist were 1.25, 25, 50 & 100 mg and 0.625, 1.2, 2.5, 5 and 10 mg, respec- tively. The Mann-Whitney U test showed statistical significance (p0.05) between RAAS-related drugs and patients’ total daily doses. We noticed more frequency of hyperkalemia in the losartan group (n=11, 5.9%) than in the ramipril group (n=4, 2.2%). Initially, the mean serum potassium was low in the ACE inhibitor (4.35±0.55) subset, and then there was augmenta- tion in the second (4.46±0.52) and third (4.52±0.55) patient consultations. The repeated measures ANOVA tests depicted the samples to be different (p<0.05) in the serum potassium measurements within the losartan group (p-=0.018) and ramipril group (p<0.001).
Conclusion: Losartan gave favorable clinical effects in CKD patients with regards to serum creatinine and potassium. How- ever, the frequency in reduction of proteinuria was profound in ramipril understudies.

Kaynakça

  • Baker, M., & Perazella, M. A. (2020). NSAIDs in CKD: Are they safe? American Journal of Kidney Diseases, 76(4), 546–557. https://doi. org/10.1053/j.ajkd.2020.03.023
  • Bakris, G. L., & Weir, M. R. (2000). Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: Is this a cause for concern? Archives of Internal Medicine, 160(5), 685–693. https:// doi.org/10.1001/archinte.160.5.685
  • Chan, J. C., Critchley, J. A., Lappe, J. T., Raskin, S. J., Snavely, D., Gold- berg, A. I., & Sweet, C. S. (1995). Randomised, double-blind, paral- lel study of the anti-hypertensive efficacy and safety of losartan potassium compared with felodipine ER in elderly patients with mild to moderate hypertension. Journal of Human Hypertension, 9(9), 765–771.
  • Collard, D., Brouwer, T. F., Peters, R. J. G., Vogt, L., & van den Born, B.-J. H. (2018). Creatinine Rise during blood pressure therapy and the risk of adverse clinical outcomes in patients with type 2 dia- betes mellitus. Hypertension (Dallas, Tex.: 1979), 72(6), 1337–1344. https://doi.org/10.1161/HYPERTENSIONAHA.118.11944
  • Coresh, J., Selvin, E., Stevens, L. A., Manzi, J., Kusek, J. W., Eggers, P. … Levey, A. S. (2007). Prevalence of chronic kidney disease in the United States. JAMA, 298(17), 2038–2047. https://doi.org/10.1001/ jama.298.17.2038
  • Council on Credentialing in Pharmacy, Albanese, N. P., & Rouse, M. J. (2010). Scope of contemporary pharmacy practice: Roles, responsibilities, and functions of pharmacists and pharmacy technicians. Journal of the American Pharmacists Association: JAPhA, 50(2), e35-69. https://doi.org/10.1331/JAPhA.2010.10510
  • Doggrell, S. A. (2001). Is Ramipril the pril for diabetes and kidney disease? Drugs of Today (Barcelona, Spain: 1998), 37(5), 321–331. https://doi.org/10.1358/dot.2001.37.5.627954
  • Duan, J., Wang, C., Liu, D., Qiao, Y., Pan, S., Jiang, D. … Liu, Z. (2019). Prevalence and risk factors of chronic kidney disease and dia- betic kidney disease in Chinese rural residents: A cross-sectional survey. Scientific Reports, 9(1), 10408. https://doi.org/10.1038/ s41598-019-46857-7
  • Esposito, C., Bellotti, N., Fasoli, G., Foschi, A., Plati, A. R., & Dal Canton, A. (2004). Hyperkalemia-induced ECG abnormalities in patients with reduced renal function. Clinical Nephrology, 62(6), 465–468. https://doi.org/10.5414/cnp62465
  • Hallan, S. I., Coresh, J., Astor, B. C., Åsberg, A., Powe, N. R., Romund- stad, S., … Holmen, J. (2006). International Comparison of the relationship of chronic kidney disease prevalence and ESRD risk. Journal of the American Society of Nephrology, 17(8), 2275–2284. https://doi.org/10.1681/ASN.2005121273
  • Hou, F. F., Xie, D., Zhang, X., Chen, P. Y., Zhang, W. R., Liang, M. … Jiang, J. P. (2007). Renoprotection of Optimal Antiproteinuric Dos- es (ROAD) Study: A randomized controlled study of benazepril and losartan in chronic renal insufficiency. Journal of the Ameri- can Society of Nephrology: JASN, 18(6), 1889–1898. https://doi. org/10.1681/ASN.2006121372
  • James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Him- melfarb, C., Handler, J. … Ortiz, E. (2014). 2014 Evidence-Based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA, 311(5), 507–520. https://doi. org/10.1001/jama.2013.284427
  • Kahvecioglu, S., Akdag, I., Gullulu, M., Arabul, M., Ersoy, A., Dilek, K. … Yurtkuran, M. (2007). Comparison of higher dose of losartan treatment with losartan plus carvedilol and losartan plus ramipril in patients with glomerulonephritis and proteinuria. Renal Failure, 29(2), 169–175. https://doi.org/10.1080/08860220601098839
  • Knoll, G. A., Cantarovitch, M., Cole, E., Gill, J., Gourishankar, S., Hol- land, D. … Fergusson, D. (2008). The Canadian ACE-inhibitor trial to improve renal outcomes and patient survival in kidney trans- plantation—Study design. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Asso- ciation - European Renal Association, 23(1), 354–358. https://doi. org/10.1093/ndt/gfm574
  • Magvanjav, O., Cooper-DeHoff, R. M., McDonough, C. W., Gong, Y., Segal, M. S., Hogan, W. R., & Johnson, J. A. (2019). Antihyperten- sive therapy prescribing patterns and correlates of blood pres- sure control among hypertensive patients with chronic kidney disease. Journal of Clinical Hypertension (Greenwich, Conn.), 21(1), 91–101. https://doi.org/10.1111/jch.13429
  • Maione, A., Annemans, L., & Strippoli, G. (2009). Proteinuria and Clin- ical outcomes in hypertensive patients. American Journal of Hyper- tension, 22(11), 1137–1147. https://doi.org/10.1038/ajh.2009.161
  • Mandal, A. K. (1997). Hypokalemia and hyperkalemia. The Medical Clinics of North America, 81(3), 611–639. https://doi.org/10.1016/ s0025-7125(05)70536-8
  • Ono, T., Sanai, T., Miyahara, Y., & Noda, R. (2013). Olmesartan is more effective than other angiotensin receptor antagonists in reducing proteinuria in patients with chronic kidney disease other than diabetic nephropathy. Current Therapeutic Research,
  • Clinical and Experimental, 74, 62–67. https://doi.org/10.1016/j.cur- theres.2013.02.002
  • Palmer, B. F. (2004). Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system. The New England Journal of Medicine, 351(6), 585–592. https://doi.org/10.1056/ NEJMra035279
  • Praga, M., Andrade, C. F., Luño, J., Arias, M., Poveda, R., Mora, J. … Campistol, J. M. (2003). Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: A double-blind, randomized clinical trial. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialy- sis and Transplant Association - European Renal Association, 18(9), 1806–1813. https://doi.org/10.1093/ndt/gfg284
  • Reardon, L. C., & Macpherson, D. S. (1998). Hyperkalemia in out- patients using angiotensin-converting enzyme inhibitors. How much should we worry? Archives of Internal Medicine, 158(1), 26–32. https://doi.org/10.1001/archinte.158.1.26
  • Ripley, E., & Hirsch, A. (2010). Fifteen years of losartan: What have we learned about losartan that can benefit chronic kidney dis- ease patients? International Journal of Nephrology and Renovascu- lar Disease, 3, 93–98.
  • Sadjadi, S. A., McMillan, J. I., Jaipaul, N., Blakely, P., & Hline, S. S. (2009). A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers. Therapeutics and Clinical Risk Man- agement, 5(3), 547–552. https://doi.org/10.2147/tcrm.s5176
  • Schmidt, M., Mansfield, K. E., Bhaskaran, K., Nitsch, D., Sørensen, H. T., Smeeth, L., & Tomlinson, L. A. (2017). Serum creatinine el- evation after renin-angiotensin system blockade and long term cardiorenal risks: Cohort study. BMJ, 356, j791. https://doi. org/10.1136/bmj.j791
  • Tikkanen, I., Omvik, P., & Jensen, H. A. (1995). Comparison of the angiotensin II antagonist losartan with the angiotensin convert- ing enzyme inhibitor enalapril in patients with essential hyper- tension. Journal of Hypertension, 13(11), 1343–1351. https://doi. org/10.1097/00004872-199511000-00017
  • Weir, M. R. (1999). Are drugs that block the renin-angiotensin system effective and safe in patients with renal insufficiency? American Journal of Hypertension, 12(S9), 195S-203S. https://doi. org/10.1016/S0895-7061(99)00104-1
  • Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C. … Wright, J. T. (2018). 2017 ACC/AHA/ AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Hypertension, 71(6), e13–e115. https://doi. org/10.1161/HYP.0000000000000065
  • Zhang, Y., He, D., Zhang, W., Xing, Y., Guo, Y., Wang, F., … Lin, S. (2020). ACE Inhibitor benefit to kidney and cardiovascular out- comes for patients with non-dialysis chronic kidney disease stages 3-5: A network meta-analysis of randomised clinical tri- als. Drugs, 80(8), 797–811. https://doi.org/10.1007/s40265-020- 01290-3.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Original Article
Yazarlar

Mohammed Salim Kt 0000-0002-8398-2737

Saravanakumar Rt Bu kişi benim 0000-0001-6044-0866

Dilip C Bu kişi benim

Yayımlanma Tarihi 28 Nisan 2022
Gönderilme Tarihi 17 Mayıs 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 52 Sayı: 1

Kaynak Göster

APA Kt, M. S., Rt, S., & C, D. (2022). The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease. İstanbul Journal of Pharmacy, 52(1), 1-7. https://doi.org/10.26650/IstanbulJPharm.2022.937821
AMA Kt MS, Rt S, C D. The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease. iujp. Nisan 2022;52(1):1-7. doi:10.26650/IstanbulJPharm.2022.937821
Chicago Kt, Mohammed Salim, Saravanakumar Rt, ve Dilip C. “The Comparison of Losartan and Ramipril on the Incidence of Hyperkalaemia Among Hypertensive Patients With Chronic Kidney Disease”. İstanbul Journal of Pharmacy 52, sy. 1 (Nisan 2022): 1-7. https://doi.org/10.26650/IstanbulJPharm.2022.937821.
EndNote Kt MS, Rt S, C D (01 Nisan 2022) The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease. İstanbul Journal of Pharmacy 52 1 1–7.
IEEE M. S. Kt, S. Rt, ve D. C, “The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease”, iujp, c. 52, sy. 1, ss. 1–7, 2022, doi: 10.26650/IstanbulJPharm.2022.937821.
ISNAD Kt, Mohammed Salim vd. “The Comparison of Losartan and Ramipril on the Incidence of Hyperkalaemia Among Hypertensive Patients With Chronic Kidney Disease”. İstanbul Journal of Pharmacy 52/1 (Nisan 2022), 1-7. https://doi.org/10.26650/IstanbulJPharm.2022.937821.
JAMA Kt MS, Rt S, C D. The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease. iujp. 2022;52:1–7.
MLA Kt, Mohammed Salim vd. “The Comparison of Losartan and Ramipril on the Incidence of Hyperkalaemia Among Hypertensive Patients With Chronic Kidney Disease”. İstanbul Journal of Pharmacy, c. 52, sy. 1, 2022, ss. 1-7, doi:10.26650/IstanbulJPharm.2022.937821.
Vancouver Kt MS, Rt S, C D. The comparison of losartan and ramipril on the incidence of hyperkalaemia among hypertensive patients with chronic kidney disease. iujp. 2022;52(1):1-7.