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Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique

Yıl 2023, Cilt: 53 Sayı: 2, 229 - 238, 30.08.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1166404

Öz

Background and Aims: Literature reveals many benefits and potentials of the stem bark extract of Prosopis africana but like other plant extracts, its use in the oral pharmaceutical formulation is limited due to its poor aqueous solubility, reduced absorption, and bioavailability. The aim of this study is to develop oral solid dispersion formulations of Prosopis africana extract to improve its dissolution and possible bioavailability.
Methods: Crushed stem bark of Prosopis africana was macerated in methanol for 72 h at room temperature. The resulting extract (PREx) was incorporated into polyethylene glycol 4000 (PEG 4000) by the solvent-evaporation and melt-fusion methods using different ratios (1:1, 1:2, 1:4) of extract to polymer; physical mixtures of the same ratio of extract to polymer were also prepared. The crystallinity of the formulations was characterized by differential scanning calorimetry (DSC), possible interaction/incompatibility between the extract and polymer was determined by Fourier transform infra-red spectroscopy (FT-IR). In vitro, release and modeling of the release profile were also determined.
Results: No interaction was found between materials used for the preparations while DSC thermograms showed a reduction in crystallinity of PREx in the solid dispersion formulations. In vitro release profile of the formulation prepared with the highest polymer concentration by the melt-fusion method (M3) showed the greatest enhancement in dissolution.
Conclusion: This study shows solid dispersion prepared by the melt-fusion method as an effective technique for the enhancement of dissolution of poorly water-soluble Prosopis africana extract.

Kaynakça

  • Achi, O. K., & Okolo, N. I. (2004). The chemical composition and some physical properties of a water-soluble gum from Prosopis africana seeds. International Journal of Food Sciences Technology, 39, 431-436. google scholar
  • Ajiboye, A. A., Agboola, D. A., Fadimu, O. Y., & Afolabi, A. O. (2013). Antibacterial, phytochemical and proximate analysis of Prosopis africana (Linn) seed and pod extract. FUTA Journal of Research in Sciences, 1, 101-109. google scholar
  • Alimata, B., Dofini, M. R., Souleymane, C., Eli, C., Noufou, O., Sey-dou, S. D., Hassanata, M., & Martin, K. (2020). The ethnobotanical survey, antibacterial activity and phytochemical screening of ex-tracts of Prosopis africana (Guill. & Perr.) Taub. European Journal of Medicinal Plants, 31, 39-47. google scholar
  • Ansari, M., & Parveen, R. (2016). Solubility and stability enhance-ment of curcumin: Improving drug properties of natural pigment. Drug Development & Therapeutics, 7, 113-116. google scholar
  • Atawodi, S. E., & Ogunbusol, F. (2009). Evaluation of anti-trypano-somal properties of four extracts of leaves, stem and root barks of Prosopis africana in laboratory animals. Biokemistri, 21, 101-108. google scholar
  • Ayanwuyi, L. O., Yaro, A. H., & Abodunde, O. M. (2010). Analgesic and anti-inflammatory effects of the methanol stem bark extract of Prosopis africana. Pharmaceutical Biology, 48, 296-299. google scholar
  • Azadi, A., Hamaid, M., & Rouini, M. R. (2013). Methotrexate-loaded chitosan nanogels as ‘Trojan Horses’ for drug delivery to brain: Preparation and in vitro/in vivo characterization. International Journal of Biological Macromolecules, 62, 523-530. google scholar
  • Bajracharya, R., Song, J. G., Lee, S. H., Jeong, S. H., & Han, H. K. (2022). Enhanced oral bioavailability of MT-102, A new anti-inflammatory agent, via a ternary solid dispersion formulation. Pharmaceutics, 14, 1-12. google scholar
  • Balata, G., & Shamrool, H. (2014). Spherical agglomeration versus solid dispersion as different trials to optimize dissolution and bio-activity of silymarin. Journal of Drug Delivery, Science & Technology, 24, 478-485. google scholar
  • Bandaranayake, W. M. (2006). Quality control, screening, toxicity, and regulation of herbal drugs in Modern Phytomedicine. Turn-ing Medicinal Plants into Drugs eds Ahmad I., Aqil F., Owais M. Weinheim:Wiley-VCH GmbH & Co. KGaA; 25-57. google scholar
  • Bangun, H., Arianto, A., Bangun, Y. S., & Nainggolan, M. (2019). An-tibacterial activity of mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract - PVP solid dispersion. Open Access Macedonian Journal of Medical Sciences, 7, 3868-3873. google scholar
  • Bello, M. I., Madusolumuo, & Igbokwe, I. (2016). Effects of Aqueous Stem Bark Extract of Prosopis africana on wistar strain rats. Interna-tional Journal of Science and Research, 5, 518-523. google scholar
  • Bhupender, S. K., Rajneesh, B., & Baljeet, S. Y. (2013). Physicochemi-cal, functional, thermal and pasting properties of starches isolat-ed from pearl millet cultivars. International Food Research Journal, 20, 1555-1561. google scholar
  • Bikiaris, D., Papageorgiou, G. C., Stergiou, A., Pavlidou, E., Karavas, E., Kanaze, F., & Georgarakis, M. (2005). Physicochemical studies on solid dispersions of poorly water-soluble drugs. Evaluation of capabilities and limitations of thermal analysis techniques. Ther-mochimica Acta, 439, 58-67. google scholar
  • C ai, Z., Lei, X., Lin, Z., Wu, F., Yang, Z., Pu, J., & Liu, Z. (2014). Prepa-ration and evaluation of sustained release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting en-hancer. Acta Pharmaceutica Sinica B 4, 86-93. google scholar
  • Camelo, P S. R., Franceschi-Messant, S., Perez, E., Girod, F. S., & Re, M. I. (2016). Factors influencing the erosion rate and the drug release kinetics from organogels designed as matrices for oral controlled release of a hydrophobic drug. Drug Development and Industrial Pharmacy, 42, 985-997. google scholar
  • C id, A. G., Simonazzi, A., Palma, S. D., & Bermudez, J. M. (2019). Solid dispersion technology as a strategy to improve the bio-availability of poorly soluble drugs. Therapeutics & Delivery, 10, 363-382. google scholar
  • Costa, A. R., Marquiafa'vel, F. S., Vaz, M. M. L., Rocha, B. A., Bue-no, P. C. P., Amaral, P. L. M., Barud, H. S., & Berreta- Silva, A. (2011). Quercetin-PVP K25 solid dispersions Preparation, thermal charac-terization and antioxidant activity. Journal of Thermal Analysis and Calorimetry, 104, 273-278. google scholar
  • E nose, A. A., Dasan, P. K., Sivaramakrishnan, H., & Shah, S. M. (2014). Formulation and characterization of solid dispersion prepared by hot melt mixing: A fast screening approach for polymer selection. Journal of Pharmaceutics, 105382, 1-13. google scholar
  • Fernandes, F. H. A., Santana, C. F., Santos, R. L., Correia, L. P., Conceic^o, M. M., & Mace'do, R. O., Medeiros, A. C. D. (2013). Thermal characterization of dried extract of medicinal plant by DSC and analytical techniques. Journal of Thermal Analysis and Calorimetry, 113, 443-447. google scholar
  • G hanem, A. S. M., Ali, H. S. M., El-Shanawany SM, Ibrahim EA (2013) Solubility and dissolution enhancement of quercetin via prepara-tion of spray dried microstructured solid dispersions. Thai Journal of Pharmaceutical Sciences, 37, 12-24. google scholar
  • G haste, R., Chougule, D. D., & Shah, R. R. (2009). Solid dispersions: An overview. Pharmacological Reviews, 7, 1-3. google scholar
  • G ouda, R., Baishya, H., & Qing, Z. H. (2017). Application of math-ematical models in drug release kinetics of carbidopa and le-vodopa ER tablets. Journal of Developing Drugs, 6, 1-8. google scholar
  • G unasekaran, T., Haile, T., Nigusse, T., & Dhanaraju, M. D. (2014). Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pacific Journal of Tropical Biomedicine, 4, S1-S7. google scholar
  • H amid, A. M., Harris, M. S., Jaweria, T., & Rabia, I. Y. (2006). Once-daily tablet formulation and in vitro release evaluation of cefpo-doxime using hydroxypropyl methylcellulose: A technical note. AAPS PharmSciTech, 7, E1-E6. google scholar
  • I brahim, I. A. A., Mohammad, M. M., Faisal, A. A., & Musa, H. (2018). Biochemical and antimicrobial activity of Prosopis Africana. Inter-national Journal of Environmental Problems, 4, 19-23. google scholar
  • Jigar, V., Jayvadan, P., & Jain, D. A. (2012). Enhancement of dissolu-tion rate of modafinil using solid dispersions with polyethyleneg-lycols. Indonesian Journal of Pharmacy, 23, 209-215. google scholar
  • Kale, K., Hapgood, K., & Stewart, P. (2009). Drug agglomeration and dissolution - What is the influence of powder mixing? Euro-pean Journal of Pharmaceutics and Biopharmaceutics, 72, 156-164. google scholar
  • Khairuddin, E., Pramono, S. B., Utomo, V., Wulandari, A., Zahrotul, W., & Clegg, F. (2016). FTIR studies on the effect of concentration of polyethylene glycol on polimerization of Shellac. Journal of Physics: Conference Series, 776 012053, 1-7. google scholar
  • Kolapo, A. L., Okunade, M. B., Adejumobi, J.A., & Ogundiya, M. O. (2009). Phytochemical composition and antimicrobial activity of Prosopis africana against some selected oral pathogens. World Journal of Agricultural Sciences, 5, 90-93. google scholar
  • Kumar, A., & Kumar, K. (2017). Review article Solid dispersion: Strategy to enhance solubility. Universal Journal of Pharmaceuti-cal Research, 5, 50-55. google scholar
  • Nagalakshmi, G., & Anuradha, R. (2017). FT-IR analysis and in vitro antibacterial activity of Prosopis juliflora. European Journal of Phar-maceutical Medical Research, 4, 322-326. google scholar
  • Nikam, V. K., Shete, S. K., & Khapare, J. P. (2020). Most promising solid dispersion technique of oral dispersible tablet. Beni-Suef University Journal Basic Applied Sciences, 9, 1-16. google scholar
  • Nitave, S. A., Chougule, N. B., & Koumaravelou, K. (2018). Formu-lation and evaluation of solid dispersion tablet of andrographis paniculata extract. Pharmacognosy Journal, 5, 1047-1054. google scholar
  • Nnamani, P. O., Kenechukwu, F. C., Chika, O. C., & Otuu, F. C. (2012). Performance of Prosopis africana pell powder (PAPP) as a novel sorbent for remediating malachite green contaminated aqua sys-tem. Scientific Research and Essays, 7, 4130-4137. google scholar
  • Odeku, O. A., Okunlola, A., & Lamprecht, A. (2013). Microbead de-sign for sustained drug release using four natural gums. Interna-tional Journal of Biological Macromolecules, 58, 113-120. google scholar
  • Odoh, U. E., Uzor, P. F., Eze, C. L., Akunne, T. C., Onyegbulam, C. M., & Osadebe, P. O. (2018). Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey. Journal of Ethno-pharmacology, 218, 1-15. google scholar
  • Okide, G. B., Odoh, U. E., & Ezugwu, C. O. (2003). Hypoglycemic activity of the gum extract of Prosopis africana seeds. Journal of Tropical Medicinal Plants, 4, 47-49. google scholar
  • Olayemi, O. J., Aboh, M., Abdullahi, R., Ekere, K. E., John, J. J., & Isimi, C. Y. (2021). Physicochemical and in vitro antimicrobial evaluation of cream and vaginal suppository formulations of the extract of the flower buds of Syzygium aromaticum (Myrtaceae). Journal of Phytomedicine and Therapeutics, 20, 685-704. google scholar
  • Olorunsola, E. O., Adedokun, M. O., Olisakwe, P. C., & Alozie, M. (2022). In vitro evaluation of Prosopis gum matrix for duodenum-targeted delivery of omeprazole. Journal of Applied Pharmaceuti-cal Science, 12, 164-171. google scholar
  • Onoue, S., Takahashi, H., Kawabata, Y., Seto, Y., Hatanaka, J., Tim-mermann, B., & Yamada, S. (2010). Formulation design and pho-tochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. Journal of Pharmaceutical Sci-ences, 99, 1871-1881. google scholar
  • Orwa, C., Mutua, A., Kindt, R., Jamnadass, R., & Anthony, S. (2009). Agroforestree Database: A tree reference and selection guide ver-sion 4.0 http://www.worldagroforestry.org/sites/treedbs/treeda-tabases.asp. google scholar
  • Parikh, A., Kathawala, K., Song, Y., Zhou, X. F., & Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bio-availability. Drug Delivery and Translational Research, 8, 1389-1405. google scholar
  • Pawar, A. R., Mundhe, P. V., Deshmukh, V. K., Pandhare, R. B., & Nandgude, T. D. (2021). Enrichment of aqueous solubility and dis-solution profile of mesalamine: In vitro evaluation of solid disper-sion. Journal of Pharmaceutical and Biological Sciences, 9, 127-135. google scholar
  • Qusa, M. H., Siddique, A. B., Nazzal, S., & El-Sayed, K. A. (2019). Nov-el olive oil phenolic (-)-oleocanthal (^)-xylitol-based solid disper-sion formulations with potent oral anti-breast cancer activities. International Journal of Pharmaceutics, 569, 118596. google scholar
  • Rahman, H. S., Othman, H. H., Hammadi, N.I., Yeap, S. K., Amin, K. M., Samad, N. A., & Alitheen, A. B. (2020). Novel drug delivery systems for loading of natural plant extracts and their biomedical applica-tions. International Journal of Nanomedicine, 15, 2439-2483. google scholar
  • Rohini, J., Muhammad, E. R., & Rabeta, M. S. (2021). An attempt to improve the solubility and stability of Ocimum tenuiflorum aque-ous leaves extract. Food Research, 5, 35-36. google scholar
  • Saidan, N., Kaus, N. H. M., Aisha, A., Hamil, M. S. R., & Ismail, Z. (2020). Accelerated stability study of Orthosiphon stamineus stan-dardised ethanolic extract and its solid dispersion. IOP confer-ence series: Environmental Earth Sciences, 596, 012091. google scholar
  • Sharma, A., Jain, C. P., & Tanwari, Y. S. (2013). Preparation and char-acterization of solid dispersions of carvedilol with poloxamer 188. Journal of the Chilean Chemical Society, 58, 1553-1557. google scholar
  • Sharma. K. S., Sahoo, J., Agrawal, S., & Kumari, A. (2019). Solid dis-persions: A technology for improving bioavailability. Journal of Analytical & Pharmaceutical Research, 8, 127-133. google scholar
  • Shehab, N. G., Shahiwala, A., Benouared, I., & Khan, R. (2020). Prep-aration and antihepatotoxicity activity of Fagonia indica extract and its solid dispersion formulation. Pakistan Journal of Pharma-ceutical Sciences, 33, 1025-1032. google scholar
  • Siepmann, J., & Peppas, N. A. (2001). Modeling of drug release from delivery systems based on hydroxypropylmethylcellulose (HPMC). Advanced Drug Delivery Reviews, 48, 139-157. google scholar
  • Singh, S., Baghel, R. S., & Yadav, L. (2021). Review on Solid Disper-sions. International Journal of Biology, Pharmacy & Allied Sciences, 10, 1078-1095. google scholar
  • Sofowora, A., Ogunbodede, E., & Onayade, A. (2013.) The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional Complementary Alternative Medicine, 10, 210-229. google scholar
  • Tafu, N. N., & Jideani, V. A. (2021). Characterization of novel solid dispersions of Moringa oleifera leaf powder using thermo-analyti-cal techniques. Processes 9, 1-20. google scholar
  • Tran, P., Pyo, Y. C., Kim, D. H., Lee, S. E., Kim, J. K., & Park, J. S. (2019). Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs. Pharmaceutics, 11, 1-26. google scholar
  • Unnisa, A., Chettupalli, A. K., Al Hagbani, T., Khalid, M., Jandraju-palli, S. B., Chandolu, S., & Hussain, T. (2022). Development of dapagliflozin solid lipid nanoparticles as a novel carrier for oral delivery: Statistical design, optimization, in-vitro and in-vivo char-acterization, and evaluation. Pharmaceutics, 15, 1-31. google scholar
  • Wani, S. D., Kakkar, V., Gautam, S. P., Gangadharappa, H. V., Ali, M., Masoodi, M. H., & Moin, A. (2021). Enhancing therapeutic poten-tial of poor aqueous soluble herbal drugs through solid disper-sion-An overview. Phytomedicine Plus, 1, 1-5. google scholar
  • Weerapol, Y., Limmatvapirat, S., Nunthanid, J., Konthong, S., Sut-tiruengwong, S., & Sriamornsak, P. (2017). Development and char-acterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents. Asian Journal of Pharmaceutical Sciences, 12, 335-343 google scholar
  • World Health Organisation; WHO. (2004) Guidelines on Safety Monitoring of Herbal Medicines in Pharmacovigilance Systems. Geneva, Switzerland. World Health Organization. google scholar
  • Wu, X., Huo, Q., Quan, Q., Yang, X., Yu, N., & Wang, Y. (2018). Opti-mizing the Formulation for Ginkgolide B Solid Dispersion. Open Life Sciences, 13, 253-262. google scholar
  • Xie, F., Yu, L., Su, B., Liu, P., Wang, J., Liu, H., & Chen, L. (2009). Rheo-logical properties of starches with different amylose/amylopectin ratios. Journal of Cereal Science, 49, 371-377. google scholar
  • Yen, C., Liang, Y., Cheng, C., Hsu, M., & Wu, Y. (2020). Oral Bio-availability enhancement and anti-fatigue assessment of the andrographolide loaded solid. International Journal of Molecular Sciences, 21, 1-18. google scholar
Yıl 2023, Cilt: 53 Sayı: 2, 229 - 238, 30.08.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1166404

Öz

Kaynakça

  • Achi, O. K., & Okolo, N. I. (2004). The chemical composition and some physical properties of a water-soluble gum from Prosopis africana seeds. International Journal of Food Sciences Technology, 39, 431-436. google scholar
  • Ajiboye, A. A., Agboola, D. A., Fadimu, O. Y., & Afolabi, A. O. (2013). Antibacterial, phytochemical and proximate analysis of Prosopis africana (Linn) seed and pod extract. FUTA Journal of Research in Sciences, 1, 101-109. google scholar
  • Alimata, B., Dofini, M. R., Souleymane, C., Eli, C., Noufou, O., Sey-dou, S. D., Hassanata, M., & Martin, K. (2020). The ethnobotanical survey, antibacterial activity and phytochemical screening of ex-tracts of Prosopis africana (Guill. & Perr.) Taub. European Journal of Medicinal Plants, 31, 39-47. google scholar
  • Ansari, M., & Parveen, R. (2016). Solubility and stability enhance-ment of curcumin: Improving drug properties of natural pigment. Drug Development & Therapeutics, 7, 113-116. google scholar
  • Atawodi, S. E., & Ogunbusol, F. (2009). Evaluation of anti-trypano-somal properties of four extracts of leaves, stem and root barks of Prosopis africana in laboratory animals. Biokemistri, 21, 101-108. google scholar
  • Ayanwuyi, L. O., Yaro, A. H., & Abodunde, O. M. (2010). Analgesic and anti-inflammatory effects of the methanol stem bark extract of Prosopis africana. Pharmaceutical Biology, 48, 296-299. google scholar
  • Azadi, A., Hamaid, M., & Rouini, M. R. (2013). Methotrexate-loaded chitosan nanogels as ‘Trojan Horses’ for drug delivery to brain: Preparation and in vitro/in vivo characterization. International Journal of Biological Macromolecules, 62, 523-530. google scholar
  • Bajracharya, R., Song, J. G., Lee, S. H., Jeong, S. H., & Han, H. K. (2022). Enhanced oral bioavailability of MT-102, A new anti-inflammatory agent, via a ternary solid dispersion formulation. Pharmaceutics, 14, 1-12. google scholar
  • Balata, G., & Shamrool, H. (2014). Spherical agglomeration versus solid dispersion as different trials to optimize dissolution and bio-activity of silymarin. Journal of Drug Delivery, Science & Technology, 24, 478-485. google scholar
  • Bandaranayake, W. M. (2006). Quality control, screening, toxicity, and regulation of herbal drugs in Modern Phytomedicine. Turn-ing Medicinal Plants into Drugs eds Ahmad I., Aqil F., Owais M. Weinheim:Wiley-VCH GmbH & Co. KGaA; 25-57. google scholar
  • Bangun, H., Arianto, A., Bangun, Y. S., & Nainggolan, M. (2019). An-tibacterial activity of mucoadhesive gastroretentive drug delivery system of alginate beads containing turmeric extract - PVP solid dispersion. Open Access Macedonian Journal of Medical Sciences, 7, 3868-3873. google scholar
  • Bello, M. I., Madusolumuo, & Igbokwe, I. (2016). Effects of Aqueous Stem Bark Extract of Prosopis africana on wistar strain rats. Interna-tional Journal of Science and Research, 5, 518-523. google scholar
  • Bhupender, S. K., Rajneesh, B., & Baljeet, S. Y. (2013). Physicochemi-cal, functional, thermal and pasting properties of starches isolat-ed from pearl millet cultivars. International Food Research Journal, 20, 1555-1561. google scholar
  • Bikiaris, D., Papageorgiou, G. C., Stergiou, A., Pavlidou, E., Karavas, E., Kanaze, F., & Georgarakis, M. (2005). Physicochemical studies on solid dispersions of poorly water-soluble drugs. Evaluation of capabilities and limitations of thermal analysis techniques. Ther-mochimica Acta, 439, 58-67. google scholar
  • C ai, Z., Lei, X., Lin, Z., Wu, F., Yang, Z., Pu, J., & Liu, Z. (2014). Prepa-ration and evaluation of sustained release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting en-hancer. Acta Pharmaceutica Sinica B 4, 86-93. google scholar
  • Camelo, P S. R., Franceschi-Messant, S., Perez, E., Girod, F. S., & Re, M. I. (2016). Factors influencing the erosion rate and the drug release kinetics from organogels designed as matrices for oral controlled release of a hydrophobic drug. Drug Development and Industrial Pharmacy, 42, 985-997. google scholar
  • C id, A. G., Simonazzi, A., Palma, S. D., & Bermudez, J. M. (2019). Solid dispersion technology as a strategy to improve the bio-availability of poorly soluble drugs. Therapeutics & Delivery, 10, 363-382. google scholar
  • Costa, A. R., Marquiafa'vel, F. S., Vaz, M. M. L., Rocha, B. A., Bue-no, P. C. P., Amaral, P. L. M., Barud, H. S., & Berreta- Silva, A. (2011). Quercetin-PVP K25 solid dispersions Preparation, thermal charac-terization and antioxidant activity. Journal of Thermal Analysis and Calorimetry, 104, 273-278. google scholar
  • E nose, A. A., Dasan, P. K., Sivaramakrishnan, H., & Shah, S. M. (2014). Formulation and characterization of solid dispersion prepared by hot melt mixing: A fast screening approach for polymer selection. Journal of Pharmaceutics, 105382, 1-13. google scholar
  • Fernandes, F. H. A., Santana, C. F., Santos, R. L., Correia, L. P., Conceic^o, M. M., & Mace'do, R. O., Medeiros, A. C. D. (2013). Thermal characterization of dried extract of medicinal plant by DSC and analytical techniques. Journal of Thermal Analysis and Calorimetry, 113, 443-447. google scholar
  • G hanem, A. S. M., Ali, H. S. M., El-Shanawany SM, Ibrahim EA (2013) Solubility and dissolution enhancement of quercetin via prepara-tion of spray dried microstructured solid dispersions. Thai Journal of Pharmaceutical Sciences, 37, 12-24. google scholar
  • G haste, R., Chougule, D. D., & Shah, R. R. (2009). Solid dispersions: An overview. Pharmacological Reviews, 7, 1-3. google scholar
  • G ouda, R., Baishya, H., & Qing, Z. H. (2017). Application of math-ematical models in drug release kinetics of carbidopa and le-vodopa ER tablets. Journal of Developing Drugs, 6, 1-8. google scholar
  • G unasekaran, T., Haile, T., Nigusse, T., & Dhanaraju, M. D. (2014). Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pacific Journal of Tropical Biomedicine, 4, S1-S7. google scholar
  • H amid, A. M., Harris, M. S., Jaweria, T., & Rabia, I. Y. (2006). Once-daily tablet formulation and in vitro release evaluation of cefpo-doxime using hydroxypropyl methylcellulose: A technical note. AAPS PharmSciTech, 7, E1-E6. google scholar
  • I brahim, I. A. A., Mohammad, M. M., Faisal, A. A., & Musa, H. (2018). Biochemical and antimicrobial activity of Prosopis Africana. Inter-national Journal of Environmental Problems, 4, 19-23. google scholar
  • Jigar, V., Jayvadan, P., & Jain, D. A. (2012). Enhancement of dissolu-tion rate of modafinil using solid dispersions with polyethyleneg-lycols. Indonesian Journal of Pharmacy, 23, 209-215. google scholar
  • Kale, K., Hapgood, K., & Stewart, P. (2009). Drug agglomeration and dissolution - What is the influence of powder mixing? Euro-pean Journal of Pharmaceutics and Biopharmaceutics, 72, 156-164. google scholar
  • Khairuddin, E., Pramono, S. B., Utomo, V., Wulandari, A., Zahrotul, W., & Clegg, F. (2016). FTIR studies on the effect of concentration of polyethylene glycol on polimerization of Shellac. Journal of Physics: Conference Series, 776 012053, 1-7. google scholar
  • Kolapo, A. L., Okunade, M. B., Adejumobi, J.A., & Ogundiya, M. O. (2009). Phytochemical composition and antimicrobial activity of Prosopis africana against some selected oral pathogens. World Journal of Agricultural Sciences, 5, 90-93. google scholar
  • Kumar, A., & Kumar, K. (2017). Review article Solid dispersion: Strategy to enhance solubility. Universal Journal of Pharmaceuti-cal Research, 5, 50-55. google scholar
  • Nagalakshmi, G., & Anuradha, R. (2017). FT-IR analysis and in vitro antibacterial activity of Prosopis juliflora. European Journal of Phar-maceutical Medical Research, 4, 322-326. google scholar
  • Nikam, V. K., Shete, S. K., & Khapare, J. P. (2020). Most promising solid dispersion technique of oral dispersible tablet. Beni-Suef University Journal Basic Applied Sciences, 9, 1-16. google scholar
  • Nitave, S. A., Chougule, N. B., & Koumaravelou, K. (2018). Formu-lation and evaluation of solid dispersion tablet of andrographis paniculata extract. Pharmacognosy Journal, 5, 1047-1054. google scholar
  • Nnamani, P. O., Kenechukwu, F. C., Chika, O. C., & Otuu, F. C. (2012). Performance of Prosopis africana pell powder (PAPP) as a novel sorbent for remediating malachite green contaminated aqua sys-tem. Scientific Research and Essays, 7, 4130-4137. google scholar
  • Odeku, O. A., Okunlola, A., & Lamprecht, A. (2013). Microbead de-sign for sustained drug release using four natural gums. Interna-tional Journal of Biological Macromolecules, 58, 113-120. google scholar
  • Odoh, U. E., Uzor, P. F., Eze, C. L., Akunne, T. C., Onyegbulam, C. M., & Osadebe, P. O. (2018). Medicinal plants used by the people of Nsukka Local Government Area, south-eastern Nigeria for the treatment of malaria: An ethnobotanical survey. Journal of Ethno-pharmacology, 218, 1-15. google scholar
  • Okide, G. B., Odoh, U. E., & Ezugwu, C. O. (2003). Hypoglycemic activity of the gum extract of Prosopis africana seeds. Journal of Tropical Medicinal Plants, 4, 47-49. google scholar
  • Olayemi, O. J., Aboh, M., Abdullahi, R., Ekere, K. E., John, J. J., & Isimi, C. Y. (2021). Physicochemical and in vitro antimicrobial evaluation of cream and vaginal suppository formulations of the extract of the flower buds of Syzygium aromaticum (Myrtaceae). Journal of Phytomedicine and Therapeutics, 20, 685-704. google scholar
  • Olorunsola, E. O., Adedokun, M. O., Olisakwe, P. C., & Alozie, M. (2022). In vitro evaluation of Prosopis gum matrix for duodenum-targeted delivery of omeprazole. Journal of Applied Pharmaceuti-cal Science, 12, 164-171. google scholar
  • Onoue, S., Takahashi, H., Kawabata, Y., Seto, Y., Hatanaka, J., Tim-mermann, B., & Yamada, S. (2010). Formulation design and pho-tochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. Journal of Pharmaceutical Sci-ences, 99, 1871-1881. google scholar
  • Orwa, C., Mutua, A., Kindt, R., Jamnadass, R., & Anthony, S. (2009). Agroforestree Database: A tree reference and selection guide ver-sion 4.0 http://www.worldagroforestry.org/sites/treedbs/treeda-tabases.asp. google scholar
  • Parikh, A., Kathawala, K., Song, Y., Zhou, X. F., & Garg, S. (2018). Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bio-availability. Drug Delivery and Translational Research, 8, 1389-1405. google scholar
  • Pawar, A. R., Mundhe, P. V., Deshmukh, V. K., Pandhare, R. B., & Nandgude, T. D. (2021). Enrichment of aqueous solubility and dis-solution profile of mesalamine: In vitro evaluation of solid disper-sion. Journal of Pharmaceutical and Biological Sciences, 9, 127-135. google scholar
  • Qusa, M. H., Siddique, A. B., Nazzal, S., & El-Sayed, K. A. (2019). Nov-el olive oil phenolic (-)-oleocanthal (^)-xylitol-based solid disper-sion formulations with potent oral anti-breast cancer activities. International Journal of Pharmaceutics, 569, 118596. google scholar
  • Rahman, H. S., Othman, H. H., Hammadi, N.I., Yeap, S. K., Amin, K. M., Samad, N. A., & Alitheen, A. B. (2020). Novel drug delivery systems for loading of natural plant extracts and their biomedical applica-tions. International Journal of Nanomedicine, 15, 2439-2483. google scholar
  • Rohini, J., Muhammad, E. R., & Rabeta, M. S. (2021). An attempt to improve the solubility and stability of Ocimum tenuiflorum aque-ous leaves extract. Food Research, 5, 35-36. google scholar
  • Saidan, N., Kaus, N. H. M., Aisha, A., Hamil, M. S. R., & Ismail, Z. (2020). Accelerated stability study of Orthosiphon stamineus stan-dardised ethanolic extract and its solid dispersion. IOP confer-ence series: Environmental Earth Sciences, 596, 012091. google scholar
  • Sharma, A., Jain, C. P., & Tanwari, Y. S. (2013). Preparation and char-acterization of solid dispersions of carvedilol with poloxamer 188. Journal of the Chilean Chemical Society, 58, 1553-1557. google scholar
  • Sharma. K. S., Sahoo, J., Agrawal, S., & Kumari, A. (2019). Solid dis-persions: A technology for improving bioavailability. Journal of Analytical & Pharmaceutical Research, 8, 127-133. google scholar
  • Shehab, N. G., Shahiwala, A., Benouared, I., & Khan, R. (2020). Prep-aration and antihepatotoxicity activity of Fagonia indica extract and its solid dispersion formulation. Pakistan Journal of Pharma-ceutical Sciences, 33, 1025-1032. google scholar
  • Siepmann, J., & Peppas, N. A. (2001). Modeling of drug release from delivery systems based on hydroxypropylmethylcellulose (HPMC). Advanced Drug Delivery Reviews, 48, 139-157. google scholar
  • Singh, S., Baghel, R. S., & Yadav, L. (2021). Review on Solid Disper-sions. International Journal of Biology, Pharmacy & Allied Sciences, 10, 1078-1095. google scholar
  • Sofowora, A., Ogunbodede, E., & Onayade, A. (2013.) The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional Complementary Alternative Medicine, 10, 210-229. google scholar
  • Tafu, N. N., & Jideani, V. A. (2021). Characterization of novel solid dispersions of Moringa oleifera leaf powder using thermo-analyti-cal techniques. Processes 9, 1-20. google scholar
  • Tran, P., Pyo, Y. C., Kim, D. H., Lee, S. E., Kim, J. K., & Park, J. S. (2019). Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs. Pharmaceutics, 11, 1-26. google scholar
  • Unnisa, A., Chettupalli, A. K., Al Hagbani, T., Khalid, M., Jandraju-palli, S. B., Chandolu, S., & Hussain, T. (2022). Development of dapagliflozin solid lipid nanoparticles as a novel carrier for oral delivery: Statistical design, optimization, in-vitro and in-vivo char-acterization, and evaluation. Pharmaceutics, 15, 1-31. google scholar
  • Wani, S. D., Kakkar, V., Gautam, S. P., Gangadharappa, H. V., Ali, M., Masoodi, M. H., & Moin, A. (2021). Enhancing therapeutic poten-tial of poor aqueous soluble herbal drugs through solid disper-sion-An overview. Phytomedicine Plus, 1, 1-5. google scholar
  • Weerapol, Y., Limmatvapirat, S., Nunthanid, J., Konthong, S., Sut-tiruengwong, S., & Sriamornsak, P. (2017). Development and char-acterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents. Asian Journal of Pharmaceutical Sciences, 12, 335-343 google scholar
  • World Health Organisation; WHO. (2004) Guidelines on Safety Monitoring of Herbal Medicines in Pharmacovigilance Systems. Geneva, Switzerland. World Health Organization. google scholar
  • Wu, X., Huo, Q., Quan, Q., Yang, X., Yu, N., & Wang, Y. (2018). Opti-mizing the Formulation for Ginkgolide B Solid Dispersion. Open Life Sciences, 13, 253-262. google scholar
  • Xie, F., Yu, L., Su, B., Liu, P., Wang, J., Liu, H., & Chen, L. (2009). Rheo-logical properties of starches with different amylose/amylopectin ratios. Journal of Cereal Science, 49, 371-377. google scholar
  • Yen, C., Liang, Y., Cheng, C., Hsu, M., & Wu, Y. (2020). Oral Bio-availability enhancement and anti-fatigue assessment of the andrographolide loaded solid. International Journal of Molecular Sciences, 21, 1-18. google scholar
Toplam 63 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Original Article
Yazarlar

Olubunmi Olayemi 0000-0001-5759-7176

Rashida Abdullahi Bu kişi benim 0000-0001-6048-026X

Yayımlanma Tarihi 30 Ağustos 2023
Gönderilme Tarihi 24 Ağustos 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 53 Sayı: 2

Kaynak Göster

APA Olayemi, O., & Abdullahi, R. (2023). Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy, 53(2), 229-238. https://doi.org/10.26650/IstanbulJPharm.2023.1166404
AMA Olayemi O, Abdullahi R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. iujp. Ağustos 2023;53(2):229-238. doi:10.26650/IstanbulJPharm.2023.1166404
Chicago Olayemi, Olubunmi, ve Rashida Abdullahi. “Enhancement of Dissolution of Prosopis Africana Stem Bark Extract by Solid Dispersion Technique”. İstanbul Journal of Pharmacy 53, sy. 2 (Ağustos 2023): 229-38. https://doi.org/10.26650/IstanbulJPharm.2023.1166404.
EndNote Olayemi O, Abdullahi R (01 Ağustos 2023) Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy 53 2 229–238.
IEEE O. Olayemi ve R. Abdullahi, “Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique”, iujp, c. 53, sy. 2, ss. 229–238, 2023, doi: 10.26650/IstanbulJPharm.2023.1166404.
ISNAD Olayemi, Olubunmi - Abdullahi, Rashida. “Enhancement of Dissolution of Prosopis Africana Stem Bark Extract by Solid Dispersion Technique”. İstanbul Journal of Pharmacy 53/2 (Ağustos 2023), 229-238. https://doi.org/10.26650/IstanbulJPharm.2023.1166404.
JAMA Olayemi O, Abdullahi R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. iujp. 2023;53:229–238.
MLA Olayemi, Olubunmi ve Rashida Abdullahi. “Enhancement of Dissolution of Prosopis Africana Stem Bark Extract by Solid Dispersion Technique”. İstanbul Journal of Pharmacy, c. 53, sy. 2, 2023, ss. 229-38, doi:10.26650/IstanbulJPharm.2023.1166404.
Vancouver Olayemi O, Abdullahi R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. iujp. 2023;53(2):229-38.