Modified curdlan-based hydrogels containing ornidazole for vaginal delivery

Year 2024, Volume: 54 Issue: 3, 322 - 335, 30.12.2024

Emine Saldamlı , Melike Sessevmez , Tilbe Çevikelli , Erdal Cevher , Genada Sinani

https://doi.org/10.26650/IstanbulJPharm.2024.1505000

Abstract

Background and Aims: This study aimed to prepare and characterize, as well as compare the potential of biopolymer-based hydrogels for topical administration of ornidazole, a commonly used drug against vaginal infections. Hydrogels were successfully prepared using curdlan (Crd), carboxymethyl curdlan (CMCrd), hydroxypropyl methyl cellulose (HPMC), and xanthan gum (XG) as biopolymers, which were used alone or blended. In addition, carboxymethylation of Crd, a natural polysaccharide polymer that is attractive in the pharmaceutical field, was carried out in-house.
Methods: The structure of the synthesised CMCrd was analysed by Fourier-transform infrared spectroscopy(FT-IR). The physicochemical, mechanical, and mucoadhesive properties of hydrogels were evaluated, then the drug release patterns from the hydrogels were examined in a simulated vaginal environment.
Results: The hydrogels exhibited a uniform appearance and were pH-compatible with the vaginal environment. The viscosity, spreadability, and drug release characteristics were dependent on the polymer type and total amount of polymer present in the hydrogels. The texture profile analysis results indicated that all formulations exhibited appropriate mechanical characteristics (hardness, compressibility, cohesiveness, and elasticity) for vaginal administration, while also demonstrating mucoadhesive properties and good stability. Carboxymethylation improved mucoadhesion of Crd.
Conclusion: The results obtained indicate that the hydrogels developed in this study can be considered promising candidates for the local treatment of vaginal infections.

Keywords

Hydrogel, Polymer, Curdlan, Ornidazole, Vaginal infection, Texture analysis

Supporting Institution

Scientific Research Projects Coordination Unit of Altinbas University

Project Number

PB2018-GÜZ-ECZ-2

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